Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide

A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC50 determination

(2014) Liusong Yin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Complexes of Two Cohorts of CLIP Peptides and HLA-DQ2 of the Autoimmune DR3-DQ2 Haplotype Are Poor Substrates for HLA-DM

(2014) L.-E. Fallang et al.   JOURNAL OF IMMUNOLOGY

Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

(2013) Monika-Sarah E. D. Schulze et al.   PLoS One

HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange

(2013) Liusong Yin et al.   Frontiers in Immunology

Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO

(2012) A. N. Kremer et al.   BLOOD

Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

(2012) Wouter Pos et al.   CELL

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications

(2012) Corrie A. Painter et al.   IMMUNOLOGICAL REVIEWS

HLA-DM: arbiter conformationis

(2012) Andrea Ferrante   IMMUNOLOGY

HLA-DM Constrains Epitope Selection in the Human CD4 T Cell Response to Vaccinia Virus by Favoring the Presentation of Peptides with Longer HLA-DM-Mediated Half-Lives

(2012) L. Yin et al.   JOURNAL OF IMMUNOLOGY

Peptide Linkage to the α-Subunit of MHCII Creates a Stably Inverted Antigen Presentation Complex

(2012) Andreas Schlundt et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity

(2012) James F. Mohan et al.   MOLECULAR IMMUNOLOGY

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

(2012) Abigail I Guce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing

(2012) Andrea Ferrante et al.   Scientific Reports

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway

(2011) Monika-Sarah ED Schulze et al.   CURRENT OPINION IN IMMUNOLOGY

An Insertion Mutant in DQA1*0501 Restores Susceptibility to HLA-DM: Implications for Disease Associations

(2011) T. Hou et al.   JOURNAL OF IMMUNOLOGY

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

(2011) C. A. Painter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

(2010) Scheherazade Sadegh-Nasseri et al.   IMMUNOLOGIC RESEARCH

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

(2010) Anne-Kathrin Anders et al.   NATURE IMMUNOLOGY

A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes

(2010) Isamu Z Hartman et al.   NATURE MEDICINE

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

Bidirectional binding of invariant chain peptides to an MHC class II molecule

(2010) S. Gunther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human monoclonal antibody with T-cell-like specificity recognizes MHC class I self-peptide presented by HLA-DR1 on activated cells

(2010) A. Wölpl et al.   TISSUE ANTIGENS

T Lymphocyte Responses to Nonpolymorphic HLA-Derived Peptides Are Associated With Chronic Renal Allograft Dysfunction

(2010) Helen J. Smith et al.   TRANSPLANTATION

Cutting Edge: HLA-DM Functions through a Mechanism That Does Not Require Specific Conserved Hydrogen Bonds in Class II MHC-Peptide Complexes

(2009) Z. Zhou et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: HLA-DM-Mediated Peptide Exchange Functions Normally on MHC Class II-Peptide Complexes That Have Been Weakened by Elimination of a Conserved Hydrogen Bond

(2009) A. Ferrante et al.   JOURNAL OF IMMUNOLOGY

HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1

(2009) Kedar Narayan et al.   MOLECULAR IMMUNOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

HLA‐DM negatively regulates HLA‐DR4‐restricted collagen pathogenic peptide presentation and T cell recognition

(2008) Shereen Amria et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Model for the Peptide-Free Conformation of Class II MHC Proteins

(2008) Corrie A. Painter et al.   PLoS One

HLA-DM Mediates Epitope Selection by a “Compare-Exchange” Mechanism when a Potential Peptide Pool Is Available

(2008) Andrea Ferrante et al.   PLoS One