Different Biochemical Properties Explain Why Two Equivalent Gα Subunit Mutants Cause Unrelated Diseases

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Molecular basis of a novel oncogenic mutation in GNAO1

(2011) M Garcia-Marcos et al.   ONCOGENE

A Structural Determinant That Renders GαiSensitive to Activation by GIV/Girdin Is Required to Promote Cell Migration

(2010) Mikel Garcia-Marcos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutational Profile of GNAQQ209 in Human Tumors

(2009) Simona Lamba et al.   PLoS One

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GNAS Defects Identified by Stimulatory G Protein α-Subunit Signalling Studies in Platelets

(2008) Kathleen Freson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

Molecular architecture of G o and the structural basis for RGS16-mediated deactivation

(2008) K. C. Slep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The same mutation in Gs  and transducin   reveals behavioral differences between these highly homologous G protein  -subunits

(2008) A. R. Zurita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA