The Epigenetic Drug 5-Azacytidine Interferes with Cholesterol and Lipid Metabolism

Epigenetic regulation in myelodysplastic syndromes: implications for therapy

(2016) Ernesto Vigna et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The role of phospholipids in the biological activity and structure of the endoplasmic reticulum

(2013) Thomas A. Lagace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia

(2013) E H Estey   LEUKEMIA

Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

(2013) Herman van Besien et al.   LEUKEMIA & LYMPHOMA

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Lumenal Lipid Metabolism

(2012) Richard Lehner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia

(2012) J. Aimiuwu et al.   BLOOD

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver

(2012) T. Ehara et al.   DIABETES

Azacitidine

(2012) Gillian M. Keating   DRUGS

Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway

(2012) Martin H. Ellis et al.   EXPERIMENTAL HEMATOLOGY

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Lipid droplet formation on opposing sides of the endoplasmic reticulum

(2012) Stephen L. Sturley et al.   JOURNAL OF LIPID RESEARCH

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

(2012) Nabil G. Seidah et al.   PLoS One

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Structural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylase

(2010) Maria Elena Meza-Avina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Accessibility of Cholesterol in Endoplasmic Reticulum Membranes and Activation of SREBP-2 Switch Abruptly at a Common Cholesterol Threshold

(2010) Anna Sokolov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis

(2010) Dandan Shan et al.   JOURNAL OF LIPID RESEARCH

A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines

(2010) Paul W. Hollenbach et al.   PLoS One

Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4+ subset and oligoclonal in the CD8+ subset

(2009) Claudio Fozza et al.   EXPERIMENTAL HEMATOLOGY

Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

(2009) Hai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Berberine decreases PCSK9 expression in HepG2 cells

(2008) Jamie Cameron et al.   ATHEROSCLEROSIS

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

(2008) Michael S. Brown et al.   JOURNAL OF LIPID RESEARCH