The Carboxyl-terminal Tail of Noxa Protein Regulates the Stability of Noxa and Mcl-1

Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1

(2013) Arnim Weber et al.   APOPTOSIS

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

(2012) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

(2012) G. J. Gores et al.   GENES & DEVELOPMENT

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

(2010) M. Baou et al.   HAEMATOLOGICA

Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

(2010) Hernando Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-Independent Degradation of Antiapoptotic MCL-1

(2010) D. P. Stewart et al.   MOLECULAR AND CELLULAR BIOLOGY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

A Stress-Responsive System for Mitochondrial Protein Degradation

(2010) Jin-Mi Heo et al.   MOLECULAR CELL

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Noxa: at the tip of the balance between life and death

(2009) C Ploner et al.   ONCOGENE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY