Article
Multidisciplinary Sciences
Murat Kirtay, Josefine Sell, Christian Marx, Holger Haselmann, Mihai Ceanga, Zhong-Wei Zhou, Vahid Rahmati, Joanna Kirkpatrick, Katrin Buder, Paulius Grigaravicius, Alessandro Ori, Christian Geis, Zhao-Qi Wang
Summary: ATR, a key regulator of DNA damage response and replication stress, also plays a role in regulating neuronal activity beyond its known functions. Deletion of ATR in neurons leads to increased intrinsic activity, aberrant firing, and heightened epileptiform activity, potentially increasing susceptibility to ataxia and epilepsy.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Haixia Zhu, Zongzhuang Wen, Aizhen Zhang, Dongyue Liu, Hongxiang Wang, Yin Cheng, Xing Yang, Yu Xiao, Jianyuan Li, Daqing Sun, Bin Wu, Jiangang Gao
Summary: This study revealed that the deficiency of RhoGDI alpha leads to reduced fertility and compromised spermatogenesis in mice, characterized by smaller testes and abnormal sperm morphology. The underlying mechanism involves the activation of the LIMK/cofilin signaling pathway, which inhibits F-actin depolymerization, resulting in testicular injury and decreased fertility. However, treatment with a Rac1 inhibitor can alleviate these effects and improve sperm quality.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shengjie Zhang, Ran Li, Yiruo Ma, Ying Yan, Mei Ma, Keqin Zhang, Yun Zhou, Ling Li, Lingling Pan, Hao Ying, Ying Xue
Summary: This study found that hypothyroidism leads to heart atrophy and cardiac dysfunction, potentially through the regulation of miR-1a and HCN2 expression. Furthermore, TSH regulates the expression of miR-1a and HCN2 as well as the activity of the HCN2 channel through TSHR, while TSH regulates the expression and function of HCN2 through miR-1a.
Article
Oncology
Subbulakshmi Karthikeyan, Patrick J. Casey, Mei Wang
Summary: This study identifies the RAB4A-RAC1 signaling axis as a key regulatory mechanism for EMT and cancer progression, suggesting a potential therapeutic approach to controlling these processes.
BREAST CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xianfeng Tang, Congpeng Wang, Guohua Chai, Dian Wang, Hua Xu, Yu Liu, Guo He, Shuqing Liu, Yiran Zhang, Yingzhen Kong, Shengjun Li, Mengzhu Lu, Ronald Sederoff, Quanzi Li, Gongke Zhou
Summary: This study identified a negative regulator of wood formation, PagDA1, in poplar trees. PagDA1 restricts cambial activity by modulating the degradation of PagWOX4, thereby affecting the development and formation of secondary xylem.
Article
Cell Biology
Junyi Wang, Lichan Yuan, Xiaohong Xu, Zhongyin Zhang, Yuhuan Ma, Leilei Hong, Junqing Ma
Summary: This study found that Trio is highly expressed in osteosarcoma and promotes the proliferation and invasion of tumor cells. Trio inhibits osteogenic differentiation of osteosarcoma cells and accelerates tumor growth.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood
Summary: The BRCA1-BARD1 complex regulates TOP2B and Pol II-mediated gene expression through phosphorylation of BRCA1 and ubiquitination of TOP2B.
Article
Neurosciences
Carlo D. Cristobal, Chih-Yen Wang, Zhongyuan Zuo, Joshua A. Smith, Aaron Lindeke-Myers, Hugo J. Bellen, Hyun Kyoung Lee
Summary: This study reveals the essential role of the protein Daam2 in the regulation of oligodendrocyte cytoskeleton and myelin formation. Daam2 regulates the levels of Gelsolin to modulate the cytoskeleton during oligodendrocyte differentiation, and its deficiency leads to myelin decompaction and motor coordination deficits. These findings highlight the critical role of cytoskeletal dynamics in myelination and provide new potential avenues for the treatment of white matter diseases.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yingmin Wu, Zhuojia Chen, Guoyou Xie, Haisheng Zhang, Zhaotong Wang, Jiawang Zhou, Feng Chen, Jiexin Li, Likun Chen, Hongxin Niu, Hongsheng Wang
Summary: This study reveals that the m(1)A demethylase ALKBH3 can regulate cancer cell glycolysis in a manner dependent on demethylation activity. The adenosine 5'-triphosphate synthase subunit ATP5D is involved in the regulation of glycolysis by ALKBH3 through m(1)A modification. The study also shows that m(1)A modification affects mRNA translation elongation and stability, and it has an impact on tumor growth and cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Cai-Xia Zang, Lu Wang, Han-Yu Yang, Jun-Mei Shang, Hui Liu, Zi-Hong Zhang, Cheng Ju, Fang-Yu Yuan, Fang-Yuan Li, Xiu-Qi Bao, Dan Zhang
Summary: Neuroinflammation is crucial in neurodegenerative diseases like PD, and the tumor suppressor HACE1 has been found to potentially regulate oxidative stress. This study demonstrates that HACE1 acts as a negative regulator of neuroinflammation by impacting Rac1 activity, thus implicating it in the pathogenesis of PD and other neurodegenerative diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Beibei Guo, Mengwei Qi, Shuai Huang, Run Zhuo, Wenxue Zhang, Yufang Zhang, Man Xu, Mei Liu, Tuchen Guan, Yan Liu
Summary: The study identified Cadherin-12 (CDH12) as a gene that promotes neurite outgrowth by affecting Rac1/Cdc42 phosphorylation. This research provides a preliminary explanation for the mechanism of CDH12 in promoting axonal extension in vitro and in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Weize Xu, Xicheng Zhang, Feng Liang, Yuhang Cao, Ziyi Li, Wenzheng Qu, Jinyu Zhang, Yanhua Bi, Chongran Sun, Jianmin Zhang, Binggui Sun, Qiang Shu, Xuekun Li
Summary: The study reveals that Tet1 deficiency in astrocytes alters morphology, impairs neuronal function, and affects learning and memory ability in mice. Tet1 deficiency induces differentially hydroxymethylated regions (DhMRs) and alters gene expression, leading to abnormal Ca2+ signaling by regulating GluA1 expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo Lei, Li Lv, Shiqiang Hu, Yikai Tang, Yi Zhong
Summary: This study found that an acute social reward experience can switch silent memory engrams into a latent state, while acute social stress causes forgetting by turning latent memory engrams into a silent state. This bidirectional switching between latent and silent engrams driven by emotion is mediated through the regulation of Rac1 activity in the hippocampus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Wei Wang, Wenqiang Chen, Junmin Wang
Summary: This study found that the FRIZZY PANICLE (FZP) gene plays an important role in regulating rice spikelet development and grain number through mediating cytokinin metabolism.
Article
Biochemistry & Molecular Biology
Batuer Aikemu, Yanfei Shao, Guang Yang, Junjun Ma, Sen Zhang, Xiao Yang, Hiju Hong, Galiya Yesseyeva, Ling Huang, Hongtao Jia, Chenxing Wang, Lu Zang, Jing Sun, Minhua Zheng
Summary: The study revealed that NDRG1 plays a crucial role in actin reorganization and tumor invasion in colorectal cancer by affecting CDC42 activation. Loss of NDRG1 disrupts the binding between RhoGDI alpha and CDC42, leading to the activation of CDC42 and downstream cascades that promote CRC invasion, and enhances tumor dissemination in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Orthopedics
Alex Benedick, Derrick M. Knapik, Dana L. Duren, James O. Sanders, Daniel R. Cooperman, Feng-Chang Lin, Raymond W. Liu
Summary: This study analyzed knee radiographs of 78 children and found that the modified Roche-Wainer-Thissen (RWT) model with demographic characteristics was more accurate in predicting years from 90% final height. Through stepwise linear regression and generalized estimating equations analysis, 7 parameters were identified as the most effective in estimating skeletal maturity.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Alex Benedick, Batzorig Bazar, Lewis G. Zirkle, Raymond W. Liu
Summary: This study evaluated the use of retrograde intramedullary nails for pediatric femoral shaft fractures across an open distal femoral physis. Results showed that this method did not lead to growth arrest of the injured femur. Further studies are needed to evaluate the safety profile of this treatment option.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Orthopedics
Noah M. Joseph, Alex Benedick, Christopher McMellen, Joshua Napora, Robert Wetzel, John Sontich, George Ochenjele
Summary: The study aimed to analyze the correlation between surgical timing and outcomes for calcaneus fractures treated using a sinus tarsi approach (STA). Results showed that patients treated acutely within 72 hours of injury using STA had minimal wound complications and no compromise on short-term functional outcomes.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Orthopedics
Noah M. Joseph, Alex Benedick, Christopher D. Flanagan, Mary A. Breslin, Heather A. Vallier
Summary: The study found that one quarter of trauma patients were diagnosed with PTSD 3 months after their injury. Age less than 45 was identified as an independent risk factor for the development of PTSD, while specific mechanisms of injury such as being a victim of crime or being struck by a motor vehicle were associated with higher risk of developing PTSD.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Orthopedics
Julio C. Castillo Tafur, Alexander Benedick, Derrick M. Knapik, Jessica L. Janes, Sarah J. Delozier, Raymond W. Liu
Summary: The modified RWT system for skeletal maturity assessment using knee radiographs has shown resilience to rotational variations, allowing bone age estimation to be performed in slightly rotated knee X-rays with minimal error margin. This finding can reduce the number of radiographs needed for assessing skeletal maturity, thereby limiting radiation exposure and expediting clinical workflow.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2021)
Article
Orthopedics
Ryan J. Furdock, Alexander J. Benedick, Grant Nelson, Don Li, Daniel R. Cooperman, James O. Sanders, Raymond W. Liu
Summary: The study found that high precision in skeletal maturity estimation can be achieved by using chronological age, sex, and 5 hip radiographic parameters, and the optimized Oxford model showed excellent performance in prediction accuracy.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2021)
Article
Orthopedics
Alexander J. Benedick, Bailyn Hogue, Ryan J. Furdock, Naveen Uli, Raymond W. Liu
Summary: In preadolescent patients, estimating skeletal maturity using knee epiphyseal:metaphyseal ratio measurement combined with chronological age and sex is comparable to using the GP technique.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2021)
Article
Orthopedics
Joshua T. Yuan, Ryan J. Furdock, Alex Benedick, Raymond W. Liu
Summary: The study found that an abbreviated version of the Modified Fels knee system, using only 2 to 3 radiographic knee parameters, estimates skeletal maturity more accurately than the Greulich and Pyle left-hand bone age system. This abbreviated system showed significant advantages in accuracy compared to the traditional bone age estimation method.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
Ryan J. Furdock, Elizabeth Cho, Alexander J. Benedick, Jiao Yu, Abdus Sattar, Raymond W. Liu
Summary: The modified Fels knee skeletal maturity system can improve the prediction of ultimate lower extremity length in the treatment of LLD, making it useful in determining the appropriate timing of epiphysiodesis.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Clinical Neurology
Richard J. Smeyne, Jeffrey B. Eells, Debotri Chatterjee, Matthew Byrne, Shaw M. Akula, Srinivas Sriramula, Dorcas P. O'Rourke, Peter Schmidt
Summary: The study aimed to determine whether prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism. The results showed that mice recovered from SARS-CoV-2 infection showed more severe loss of substantia nigra pars compacta dopaminergic neurons after receiving the mitochondrial toxin compared to mice infected with SARS-CoV-2 or receiving the toxin alone.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Jin-Bin Tian, Jane Yang, William C. Joslin, Veit Flockerzi, Steven A. Prescott, Lutz Birnbaumer, Michael X. Zhu
Summary: Transient receptor potential canonical 4 (TRPC4) is a receptor-operated cation channel that can sense neurotransmission through G(q/11)- and G(i/o)-coupled receptors. TRPC4 mediates a depolarizing plateau in lateral septal neurons, shutting down action potential firing, and the duration of the depolarization depends on the strength of G(i/o) stimulation. The depolarizing plateau is dependent on G(q/11)-coupled group I metabotropic glutamate receptors and G(i/o)-coupled gamma-aminobutyric acid type B receptors, while the hyperpolarization is mediated by G(i/o) activation of GIRK channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Elena Kozina, Matthew Byrne, Richard Jay Smeyne
Summary: Mutations in the LRRK2 gene contribute to the development of Parkinson's disease. Neurodegenerative cascades may be initiated by signals from the peripheral immune system. Replacing mutant LRRK2 with the wild-type form in lymphocytes can reduce inflammation and rescue neuron loss. Immune dysfunction may play a key role in familial Parkinson's disease.
NPJ PARKINSONS DISEASE
(2022)
Article
Cell Biology
Xinghua Feng, Jian Xiong, Weijie Cai, Jin-Bin Tian, Michael X. Zhu
Summary: This study revealed that the three OcTPCs form phosphoinositide-activated Na+ channels with different ligand selectivity, voltage dependence, and extracytosolic pH sensitivity. These findings provide important clues for further research and understanding of the function and regulation of these three two-pore channels.
Biographical-Item
Neurosciences
Richard J. Smeyne
NPJ PARKINSONS DISEASE
(2023)
Article
Critical Care Medicine
Natasha M. Simske, Trenton Rivera, Bryan O. Ren, Alex Benedick, Megen Simpson, Mark Kalina, Sarah B. Hendrickson, Heather A. Vallier
Summary: This study investigated the resources provided by VOCARP, their utilization, and their impact on recidivism. It found that the use of mental health services was associated with lower recidivism rates. However, despite substantial engagement, the efficacy in terms of reducing recidivism seems limited to specific subgroups or resource utilization.
TRAUMA SURGERY & ACUTE CARE OPEN
(2021)