Interactions among Cytochromes P450 in Microsomal Membranes

The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes

(2014) Hyun-Hee Jang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers

(2014) Janani Prahlad et al.   JOURNAL OF NEUROCHEMISTRY

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

(2014) B. C. Monk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal role of P450–P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

(2013) Dmitri R. Davydov et al.   BIOCHEMICAL JOURNAL

Behavior of Human Cytochromes P450 on Lipid Membranes

(2013) Karel Berka et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation

(2013) Javier L. Baylon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying Cytochrome P450 Functional Networks and Their Allosteric Regulatory Elements

(2013) Jin Liu et al.   PLoS One

A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET)

(2013) Elena V. Sineva et al.   PLoS One

Effect of homomeric P450–P450 complexes on P450 function

(2012) James R. Reed et al.   BIOCHEMICAL JOURNAL

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA

(2012) Soi H. Bui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions

(2011) Dmitri R Davydov   Expert Opinion on Drug Metabolism & Toxicology

Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET)

(2011) Dmitri R. Davydov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of P450·P450 complexes and their effect on P450 function

(2011) James R. Reed et al.   PHARMACOLOGY & THERAPEUTICS

Structure and Dynamics of the Membrane-Bound Cytochrome P450 2C9

(2011) Vlad Cojocaru et al.   PLoS Computational Biology

CYP2C8 Exists as a Dimer in Natural Membranes

(2010) G. Hu et al.   DRUG METABOLISM AND DISPOSITION

CYP2C9-CYP3A4 Protein-Protein Interactions: Role of the Hydrophobic N Terminus

(2010) M. Subramanian et al.   DRUG METABOLISM AND DISPOSITION

Functional Interactions between Cytochromes P450 1A2 and 2B4 Require Both Enzymes to Reside in the Same Phospholipid Vesicle

(2010) James R. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

(2009) Dmitri R. Davydov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis

(2009) M. Subramanian et al.   DRUG METABOLISM AND DISPOSITION

Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis

(2009) Slavica Praporski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

(2009) Ana M Gomes et al.   PHARMACOGENOMICS

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4

(2008) Dmitri R. Davydov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

(2008) Dmitri R Davydov et al.   Expert Opinion on Drug Metabolism & Toxicology

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein

(2007) Harshica Fernando et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers

(2002) Nora S. Green et al.   PROTEIN SCIENCE