Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

(2013) C.T. Shearn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)

(2013) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Susceptibility of L-FABP−/−mice to oxidative stress in early-stage alcoholic liver

(2013) Rebecca L. Smathers et al.   JOURNAL OF LIPID RESEARCH

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis

(2013) Colin T. Shearn et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice

(2012) Hannah Everitt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein Carbonylation in a Murine Model for Early Alcoholic Liver Disease

(2012) James J. Galligan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells

(2012) Colin T. Shearn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

(2012) Rebecca L. Smathers et al.   PLoS One

Limited Therapeutic Effect of N-Acetylcysteine on Hepatic Insulin Resistance in an Experimental Model of Alcohol-Induced Steatohepatitis

(2011) Mashiko Setshedi et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells

(2011) Sébastien Anthérieu et al.   HEPATOLOGY

Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice

(2011) Tung Ming Leung et al.   HEPATOLOGY

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK

(2011) Jun Xu et al.   JOURNAL OF HEPATOLOGY

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

(2011) C. T. Shearn et al.   MOLECULAR PHARMACOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability

(2010) Suofu Qin et al.   EXPERIMENTAL EYE RESEARCH

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An energetic tale of AMPK-independent effects of metformin

(2010) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice

(2009) Zheng Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition

(2009) Lei O. Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation

(2009) J. R. Roede et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II

(2009) Jun-o Deguchi et al.   LABORATORY INVESTIGATION

Alcohol and lipid metabolism

(2008) Margaret Sozio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation

(2008) Suthat Liangpunsakul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption

(2008) James R. Roede et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal

(2008) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver

(2007) Javier García-Villafranca et al.   BIOCHIMIE