cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis

Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

(2012) James Mu et al.   PLoS One

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

(2011) Jianxin Yang et al.   BMC GENOMICS

Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides

(2011) C. Watanabe et al.   DIABETES

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

(2009) Maziyar Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

(2009) Derek M. Erion et al.   Cell Metabolism

CRTC2 (TORC2) Contributes to the Transcriptional Response to Fasting in the Liver but Is Not Required for the Maintenance of Glucose Homeostasis

(2009) John Le Lay et al.   Cell Metabolism

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

(2009) D. M. Erion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE