Review
Neurosciences
David Ramos-Vicente, Seth G. N. Grant, Alex Bayes
Summary: Glutamate is the major excitatory neurotransmitter in both vertebrate and invertebrate nervous systems. The evolution of glutamate receptors is more complex than anticipated, with recent research proposing a new classification system for ionotropic glutamate receptors. Additionally, the evolution of animal metabotropic glutamate receptors has resulted in the formation of four classes instead of three previously recognized.
Review
Neurosciences
Roberta Celli, Francesco Fornai
Summary: The review focuses on the role of ionotropic glutamate receptors in seizures and the clinical development of iGlu receptor antagonists for drug-resistant epilepsy. Antagonists inhibit experimental seizures while agonists worsen them, but clinical development is limited by adverse effects. Perampanel is the only drug specifically targeting iGlu receptors marketed for focal epilepsy.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Review
Biochemistry & Molecular Biology
Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Wong
Summary: This article reviews how glutamate handling and glutamatergic function are affected by neuroinflammation and their contribution to cognitive impairment. The authors summarize the current data regarding glutamate in neurotransmission, including its receptors and regulation. They also examine the impact of inflammation on glutamate handling and neurotransmission, focusing on changes in glial cells and the effect of cytokines. Finally, they discuss the implications of these changes for perioperative neuroinflammation and perioperative neurocognitive disorders.
Review
Biochemistry & Molecular Biology
Guendalina Olivero, Alessandra Roggeri, Anna Pittaluga
Summary: Autoantibodies against NMDA and AMPA receptors in the central nervous system can lead to neurological and psychiatric symptoms and disrupt synaptic communication. Understanding the molecular mechanisms involved in these autoantibody-mediated effects is crucial for understanding their pathogenic role in central disorders and developing new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Summary: Ketamine, a well-known NMDA receptor antagonist, exerts rapid antidepressant effects by enhancing excitatory synaptic strength. These findings suggest that promoting NMDA receptor activation or enhancing NMDA receptor-dependent synaptic potentiation may be an effective strategy for antidepressant treatment.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Aaron J. Salisbury, Christopher A. Blackwood, Jean Lud Cadet
Summary: The expression of glutamate receptors in the rat hippocampus showed changes after the cessation of oxycodone self-administration, with differences observed between long-access and short-access rats. These changes were associated with increased craving and drug-seeking behavior, especially after long periods of withdrawal. Further studies are necessary to understand the molecular mechanisms involved in these alterations.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Sebastiano A. Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggio
Summary: Several studies have shown that chronic stress has a negative effect on recognition memory, but the effects of acute stress on this cognitive ability have not been well studied. This study aimed to investigate the impact of acute stress on recognition memory consolidation in a sex-dependent manner. The results showed that acute stress did not affect memory performance in male and female mice immediately after training, but it altered memory performance after a 24-hour delay, with sex-dependent effects.
NEUROBIOLOGY OF STRESS
(2023)
Article
Medicine, Research & Experimental
Neda Valian, Marziyeh Sorayya, Sareh Asadi, Fatemeh Sherafati, Ali Ershad, Sara Savaheli, Abolhassan Ahmadiani
Summary: The study suggests that preconditioning with ultra-low dose of tramadol can reduce seizures induced by high dose tramadol, potentially through upregulation of Norbin and downregulation of NR1 and GluR1.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Falko Lange, Julia Hoernschemeyer, Timo Kirschstein
Summary: The progression of glioblastomas and tumor-associated epilepsy is closely linked through various pathophysiological mechanisms involving the neurotransmitter glutamate. Current research focuses on the role of glutamate receptors in these diseases and discusses future interventions to interfere with the glutamatergic network.
Review
Behavioral Sciences
Fawaz Alasmari, Deen B. Sari, Hasan Alhaddad, Salim S. Al-Rejaie, Youssef Sari
Summary: This review explores the interactive role of acid-sensing ion channels (ASICs) and ionotropic glutamate receptors (iGluRs) in opioid dependence. The dysregulation of ASICs and iGluRs may play a crucial role in drug abuse and addiction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Sehoon Won, Katherine W. Roche
Summary: Phosphorylation regulates glutamate receptor trafficking and plays a key role in synaptic transmission and plasticity. The protein tyrosine phosphatase STEP61 is involved in differentially regulating NMDARs and AMPARs, and has been implicated in various neurological disorders. Its interplay with Fyn and GluN2B-containing NMDARs has been extensively studied, demonstrating its importance in synaptic function.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
M. J. Olivares, A. Flores, R. von Bernhardi, J. Eugenin
Summary: Central respiratory chemoreceptors play a key role in maintaining respiratory homeostasis by sensing CO2 and H+ levels in the brain and activating the respiratory neural network. Glutamatergic neurons and astrocytes in specific brain regions, such as the RTN, contribute to this process by releasing ATP in response to hypercapnia and D-serine and glutamate as gliotransmitters.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Neurosciences
S. Murat Durakoglugil, R. Catherine Wasser, H. Connie Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz
Summary: Alzheimer's disease is characterized by the accumulation of Aβ plaques and neurofibrillary tangles, leading to synaptic dysfunction. Reelin protects synapses against Aβ toxicity through ApoE receptors. Experiments showed that Reelin modulates mGluR-LTD, potentially impacting memory consolidation or neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kseniya N. Sedenkova, Denis V. Zverev, Anna A. Nazarova, Mstislav I. Lavrov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel'yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin
Summary: Novel bis(pyrimidines) were studied as positive allosteric modulators (PAMs) of AMPA receptors, and ten compounds were found to have potentiating properties. Molecular modeling and prediction suggested that this type of compound could serve as potential lead compounds for neuroprotective drugs.
Article
Biochemistry & Molecular Biology
Noel A. Warren, Georgios Voloudakis, Yonejung Yoon, Nikolaos K. Robakis, Anastasios Georgakopoulos
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Biochemical Research Methods
Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket Milind Nigam, Steven L. Carroll, Bengt Winblad, Nenad Bogdanovic, Gael Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O. Tjernberg, Susanne Frykman
MOLECULAR & CELLULAR PROTEOMICS
(2020)
Article
Geriatrics & Gerontology
Hazal Haytural, Jolanta L. Lundgren, Tansu B. Kose, Tomas Jorda-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundstrom, Gael Barthet, Lars O. Tjernberg, Susanne Frykman
FRONTIERS IN AGING NEUROSCIENCE
(2019)
Review
Neurosciences
Gael Barthet, Christophe Mulle
PROGRESS IN NEUROBIOLOGY
(2020)
Article
Biophysics
SoRi Jang, Zhao Xuan, Ross C. Lagoy, Louise M. Jawerth, Ian J. Gonzalez, Milind Singh, Shavanie Prashad, Hee Soo Kim, Avinash Patel, Dirk R. Albrecht, Anthony A. Hyman, Daniel A. Colon-Ramos
Summary: This study systematically examined the dynamic subcellular localization of glycolytic protein phospho-fructokinase-1/PFK-1.1 in Caenorhabditis elegans, showing that PFK-1.1 can form condensates near synapses in neurons in response to energy stress and exhibit liquid-like properties. The findings suggest that PFK-1.1 condensates may represent novel metabolic subcompartments.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
YoneJung Yoon, Georgios Voloudakis, Nathan Doran, Emily Zhang, Christina Dimovasili, Lei Chen, Zhiping Shao, Spyros Darmanis, Cheuk Tang, Jun Tang, Victoria X. Wang, Patrick R. Hof, Nikolaos K. Robakis, Anastasios Georgakopoulos
Summary: The study reveals that PS1 FAD mutations impair the angiogenic functions of endothelial cells in the brain, leading to reduced neovascularization and decreased neuronal survival and cognitive recovery after ischemia. These effects occur independently of neuropathological hallmarks of AD, suggesting that they may play a role downstream of mutant effects on vascular growth and neural survival.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Benjamin J. A. Robert, Maite M. Moreau, Steve Dos Santos Carvalho, Gael Barthet, Claudia Racca, Mehdi Bhouri, Anne Quiedeville, Maurice Garret, Benedicte Atchama, Alice Shaam Al Abed, Christelle Guette, Deborah J. Henderson, Aline Desmedt, Christophe Mulle, Aline Marighetto, Mireille Montcouquiol, Nathalie Sans
Article
Clinical Neurology
Tomas Jorda-Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelieres, Susanne Frykman, Ulrike Mueller, Christophe Mulle, Gael Barthet
Summary: The distribution of amyloid precursor protein (APP) and its fragments is altered in Alzheimer's disease (AD), leading to their accumulation around amyloid plaques with presynaptic proteins. This finding is associated with histopathological features and familial AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Adam Gorlewicz, Gael Barthet, Stefano Zucca, Peggy Vincent, Marilena Griguoli, Noelle Grosjean, Grzegorz Wilczynski, Christophe Mulle
Summary: Kainate receptors (KARs) play a crucial role in regulating synaptic circuits through ionotropic or metabotropic mechanisms. This study reveals that the acute convulsive effect of kainate is primarily dependent on GluK2/GluK5 containing KARs, while the convulsive activity induced by pilocarpine and pentylenetetrazol is not affected by the absence of KARs. Interestingly, the genetic inactivation of GluK2 increases susceptibility to acute pilocarpine-induced seizures.
Article
Neurosciences
Sisi Yang, Daehun Park, Laura Manning, Sarah E. Hill, Mian Cao, Zhao Xuan, Ian Gonzalez, Yongming Dong, Benjamin Clark, Lin Shao, Ifechukwu Okeke, Agustin Almoril-Porras, Jihong Bai, Pietro De Camilli, Daniel A. Colon-Ramos
Summary: This study reveals the regulated key steps of ATG-9 trafficking at presynaptic sites and provides evidence that ATG-9 exo-endocytosis couples autophagosome biogenesis at presynaptic sites with the activity-dependent synaptic vesicle cycle.
Article
Cell Biology
Minsuk Kwak, Kaden M. Southard, Woon Ryoung Kim, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Hyun Jung Lee, Minji An, Seo Hyun Choi, Yunmin Jung, Kunwoo Noh, Justin Farlow, Anastasios Georgakopoulos, Nikolaos K. Robakis, Min K. Kang, Matthew L. Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev J. Gartner, Young-wook Jun
Summary: Adherens junctions (AJs) play a crucial role in organizing proteolytic hotspots and microdomains for the processing of transmembrane proteins such as Notch. Membrane microdomains within AJs coordinate regulated intramembrane proteolysis (RIP), while those outside AJs mediate the engagement of Notch ligand-receptor interactions. This mechanism directs the differentiation of neural progenitor cells and regulates the proteolysis of other cell-surface receptors.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhao Xuan, Sisi Yang, Benjamin Clark, Sarah E. Hill, Laura Manning, Daniel A. Colon-Ramos
Summary: Autophagy is crucial for cellular homeostasis and function. The long isoform of Clarinet protein (CLA-1L) has been identified to play a role in regulating the sorting of autophagy protein ATG-9 at synapses and in presynaptic autophagy. Disruption of CLA-1L leads to abnormal accumulation of ATG-9-containing vesicles enriched with clathrin, suggesting distinct mechanisms for sorting ATG-9-containing vesicles and synaptic vesicles.
Editorial Material
Cell Biology
Zhao Xuan, Daniel A. Colon-Ramos
Summary: Through forward genetic screens in C. elegans neurons, researchers identified the long isoform of active zone protein CLA-1 as crucial for sorting ATG-9-containing vesicles at the presynapse. Disruption of CLA-1 L leads to abnormal accumulation of clathrin-enriched ATG-9 vesicles. This study reveals novel roles for active zone proteins in the sorting of ATG-9 and in presynaptic macroautophagy/autophagy.
Article
Clinical Neurology
Hazal Haytural, Tomas Jorda-Siquier, Bengt Winblad, Christophe Mulle, Lars O. Tjernberg, Ann-Charlotte Granholm, Susanne Frykman, Gael Barthet
Summary: The study found reduced levels of several presynaptic proteins in Alzheimer's disease cases, specifically in the outer molecular layer of the dentate gyrus, with other hippocampal sub-fields unaffected. This highlights the distinctive vulnerability of the outer molecular layer of the dentate gyms and supports the notion of presynaptic failure in Alzheimer's disease.
BRAIN COMMUNICATIONS
(2021)
Article
Clinical Neurology
Md Al Rahim, Yonejung Yoon, Christina Dimovasili, Zhiping Shao, Qian Huang, Emily Zhang, Nebojsa Kezunovic, Lei Chen, Adam Schaffner, George W. Huntley, Iban Ubarretxena-Belandia, Anastasios Georgakopoulos, Nikolaos K. Robakis
BRAIN COMMUNICATIONS
(2020)