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Neurosciences
Anna Caly, Malgorzata A. Sliwinska, Magdalena Ziolkowska, Kacper Lukasiewicz, Roberto Pagano, Jakub M. Dzik, Katarzyna Kalita, Tytus Bernas, Michael G. Stewart, K. Peter Giese, Kasia Radwanska
Summary: A study using IntelliCage examined the behavioral processes supporting spatial choices of aged female mice living in a group, finding that old animals use behavioral strategies characterized by an increased tendency for perseverative visits and social interactions, resulting in a robust preference for the reward corner during the spatial choice task.
JOURNAL OF NEUROSCIENCE
(2021)
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Biochemistry & Molecular Biology
Emran Hossen, Yasuhiro Funahashi, Md. Omar Faruk, Rijwan Uddin Ahammad, Mutsuki Amano, Kiyofumi Yamada, Kozo Kaibuchi
Summary: Rho-kinase phosphorylates PSD-93 downstream of NMDARs, increasing its association with PSD-95 and NMDARs to regulate structural synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zheng Shen, Daxiao Sun, Adriana Savastano, Sara Joana Varga, Maria-Sol Cima-Omori, Stefan Becker, Alf Honigmann, Markus Zweckstetter
Summary: Alzheimer's disease is characterized by progressive memory loss and cognitive impairment. A study found that the protein Tau, which is associated with cognitive dysfunction in Alzheimer's disease, can disrupt the formation and function of droplets in the postsynaptic density. This research provides insights into the molecular mechanisms underlying synaptic dysfunction in Alzheimer's disease.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Lingye Zhang, Anni Zhou, Shengtao Zhu, Li Min, Si Liu, Peng Li, Shutian Zhang
Summary: This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Lin Gao, Ru Zhao, Junmei Liu, Wenbo Zhang, Feifei Sun, Qianshuo Yin, Xin Wang, Meng Wang, Tingting Feng, Yiming Qin, Wenjie Cai, Qianni Li, Hanchen Dong, Xueqing Chen, Xueting Xiong, Hui Liu, Jing Hu, Weiwen Chen, Bo Han
Summary: KIF15 overexpression in CRPC is associated with enhanced EGFR signaling, linking it to disease progression and suggesting KIF15 as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Li, Yue Wu, Tao Xue, Jing He, Lei Zhang, Yutong Liu, Jinlan Zhao, Zhenzhong Chen, Minjuan Xie, Bin Xiao, Yingshan Ye, Sifei Qin, Qingqiu Tang, Mengfan Huang, Hangfei Zhu, N. Liu, Fukun Guo, Lin Zhang, Lu Zhang
Summary: The study found that the regulation of Cdc42 signaling in the hippocampus plays an important role in the morphological and behavioral adaptations to cocaine addiction. Knockout or mutation of Cdc42 blocked the increase in synaptic plasticity in hippocampal neurons, leading to a decrease in conditioned place preference memory and spatial learning and memory. The Cdc42 signaling pathway correlates specific brain regions with cocaine-induced CPP behavior.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Liang Wang, Jiayi Wang, Xiaolin Yin, Xin Guan, Ying Li, Chenqi Xin, Jing Liu
Summary: High expression of GIPC2 is significantly associated with distant metastasis and poor prognosis in prostate cancer. GIPC2, as an exosomal molecule, promotes metastatic capabilities of prostate cancer cells. By binding to the WNT co-receptor, GIPC2 activates WNT signaling pathway, thereby stimulating prostate cancer metastasis.
Article
Microbiology
Yu Huang, Shuangquan Yan, Yuzhu Li, Xuefeng Ai, Xi Yu, Yan Ge, Xi Lv, Lin Fan, Jianping Xie
Summary: The study reveals that MfpD, a GTPase-activating protein (GAP), is involved in regulating fluoroquinolone resistance. Through genetic and biochemical experiments, it was shown that MfpD acts as a GAP for MfpB, playing a crucial role in FQs resistance.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Medicinal
Jie Zang, Fei Ye, Sara M. o. Solbak, Lars J. Hoj, Mingjie Zhang, Anders Bach
Summary: The study focused on the druggability of the PSD-95 PDZ1-2 domain, using fragment screening to identify four promising fragments that could serve as starting points for small-molecule PDZ domain inhibitors optimization. The results demonstrate the successful application of fragment screening to PDZ1-2 of PSD-95, unveiling novel fragments with potential for drug development.
Article
Biochemistry & Molecular Biology
Eva Wisniewski, Domonkos Czaran, Fanni Kovacs, Eniko Bahurek, Afrodite Nemeth, Peter Sasvari, Gergo Szanda, Aladar Pettko-Szandtner, Eva Klement, Erzsebet Ligeti, Roland Csepanyi-Komi
Summary: This study reveals the regulatory role of different phosphorylation patterns on the GAP activity, superoxide production, and phagocytic effect of ARHGAP25.
Article
Biochemistry & Molecular Biology
Roberta Giaccari, Francesco Marchesani, Carlotta Compari, Emilia Fisicaro, Andrea Mozzarelli, Barbara Campanini, Stefano Bettati, Stefano Bruno, Serena Faggiano
Summary: Human serine racemase (hSR) is an important enzyme in glutamatergic neurotransmission, and its activity is regulated by various factors, including its interaction with other protein partners. This study investigated the interaction between hSR and postsynaptic density protein 95 (PSD-95), and found that their binding is weak and may require the involvement of a third protein partner to stabilize it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Javier R. Balboa, Dominik J. Essig, Sana Ma, Nichlas Karer, Louise S. Clemmensen, Soren W. Pedersen, Andreas C. Joerger, Stefan Knapp, Soren Ostergaard, Kristian Stromgaard
Summary: The complex of NMDAR, nNOS, and PSD-95 is an important therapeutic target for acute ischemic stroke. By designing a cyclic nNOS β-hairpin mimetic peptide and generating peptide arrays, a potent inhibitor of the nNOS/PSD-95 interaction was identified.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Eike K. Mahlandt, Gabriel Kreider-Letterman, Anna O. Chertkova, Rafael Garcia-Mata, Joachim Goedhart
Summary: In this study, relocation sensor candidates for Rac and Cdc42 were identified and their efficiency was improved using a multi-domain approach. Optimized sensors for Cdc42 were found to have sufficient relocation efficiency and specificity. These findings enable the wider application of Rho GTPase relocation sensors and were showcased by the detection of local endogenous Cdc42 activity at assembling invadopodia. The characterization and optimization of relocation sensors will broaden their application and acceptance.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Manil Kanade, Ningthoujam Birjeet Singh, Sonal Lagad, Jyoti Baranwal, Pananghat Gayathri
Summary: Two small Ras-like GTPases, MglA and SofG, work together to drive cell polarity and motility in Myxococcus xanthus. MglA regulates cell motility and polarity reversals, while SofG regulates social motility enabled by the type IV pili machinery. The biochemical studies showed that MglB acts as a GAP for both GTPases, potentially contributing to concerted regulation of their activities in motility.
Review
Biology
Rui Dong, Xuejun Li, Kwok-On Lai
Summary: PRMT8, among the nine mammalian protein arginine methyltransferases, stands out for its restricted expression in the nervous system and being the only membrane-bound PRMT. Studies have shown its involvement in various neuronal functions such as dendritic growth, synapse maturation, and synaptic plasticity. There is also emerging evidence suggesting a potential role of PRMT8 in neurological diseases.
Article
Biochemistry & Molecular Biology
Oanh Thi Tu Le, Oh Yeon Cho, Mai Hoang Tran, Jung Ah Kim, Sunghoe Chang, Ilo Jou, Sang Yoon Lee
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Yoonju Kim, Sang-Eun Lee, Joohyun Park, Minhyung Kim, Boyoon Lee, Daehee Hwang, Sunghoe Chang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Cell Biology
Chang Man Ha, Daehun Park, Yoonju Kim, Myeongsu Na, Surabhi Panda, Sehoon Won, Hyun Kim, Hoon Ryu, Zee Yong Park, Mark M. Rasenick, Sunghoe Chang
JOURNAL OF CELL SCIENCE
(2015)
Editorial Material
Biochemistry & Molecular Biology
Sang-Eun Lee, Sunghoe Chang
Article
Multidisciplinary Sciences
Sang-Eun Lee, Yoonju Kim, Jeong-Kyu Han, Hoyong Park, Unghwi Lee, Myeongsu Na, Soomin Jeong, ChiHye Chung, Gianluca Cestra, Sunghoe Chang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Joohyun Park, Oh Yeon Cho, Jung Ah Kim, Sunghoe Chang
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Yu Jin Kim, Hye-Sun Lim, Yoonju Kim, Jun Lee, Bu-Yeo Kim, Soo-Jin Jeong
Article
Neurosciences
Bu-Yeo Kim, Hye-Sun Lim, Yoonju Kim, Yu Jin Kim, Imhoi Koo, Soo-Jin Jeong
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yoonju Kim, You-Na Jang, Ji-Young Kim, Nari Kim, Seulgi Noh, Hyeyeon Kim, Bridget N. Queenan, Ryan Bellmore, Ji Young Mun, Hyungju Park, Jong Cheol Rah, Daniel T. S. Pak, Kea Joo Lee
Article
Plant Sciences
Yu Jin Kim, Eunjin Sohn, Hye-Sun Lim, Yoonju Kim, Joo-Hwan Kim, Soo-Jin Jeong
Summary: Bauhinia coccinea extracts were analyzed for chemical composition and studied for their effects on neuroprotection, antioxidation, and Alzheimer's disease marker molecules. The results showed that the extracts exhibit anti-AChE activation and A beta aggregation activities, suggesting them as potential sources for Alzheimer's disease medication.
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yoonju Kim, Hye Ryeong Lim, Hyung-Joon Kim, Byong Seo Park, Jae Geun Kim, Sang-Joon Park, Chang Man Ha
Summary: Recent advances in optical clearing techniques have improved deep tissue imaging by reducing light scattering and absorption. However, current methods have limitations and are complex. Researchers have developed a one-step tissue clearing solution called AICI that can rapidly clear and match refractive index, allowing for imaging without additional processing. AICI has low viscosity and remains fluid for extended periods of time, making it useful for various optical imaging applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chang Man Ha, Dong Hee Kim, Tae Hwan Lee, Han Rae Kim, Jungil Choi, Yoonju Kim, Dasol Kang, Jeong Woo Park, Sergio R. Ojeda, Jin Kwon Jeong, Byung Ju Lee
Summary: Preproenkephalin (PPE) is a precursor molecule for multiple endogenous opioid peptides, and NELL2 plays a dual role in regulating PPE gene expression intracellularly and extracellularly. This study reveals the spatio-specific role of NELL2 in the homeostatic regulation of PPE gene expression.
MOLECULES AND CELLS
(2022)
Article
Chemistry, Medicinal
Yu Jin Kim, Hye-Sun Lim, Yoonju Kim, Jun Lee, Bu-Yeo Kim, Soo-Jin Jeong
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Biochemistry & Molecular Biology
Daehun Park, Myeongsu Na, Jung Ah Kim, Unghwi Lee, Eunji Cho, Mirye Jang, Sunghoe Chang