Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
James A. Conway, Grant Kinsman, Edgar R. Kramer
Summary: Parkinson's disease is a neurodegenerative disease with unclear molecular pathologies. Enhancing the clearance of alpha-synuclein, a proposed causative protein, is a central idea for PD research. NEDD4 ligases have been shown to influence the degradation of alpha-synuclein and may be potential therapeutic targets for PD. Understanding the expression and function of NEDD4 ligases in the brain is crucial for uncovering the mechanisms of PD.
Review
Cell Biology
Carla L. Sanchez-Lafuente, Lisa E. Kalynchuk, Hector J. Caruncho, Juan Ausio
Summary: This article reviews the interplay between MeCP2, synaptic plasticity, and stress, highlighting the role of MeCP2 in the transcriptional regulation of genes associated with neuronal plasticity. It also provides evidence linking dysregulation of MeCP2 expression to depressive symptoms induced by chronic stress. MeCP2 is considered a promising target for the development of more effective therapeutics for stress-related disorders such as depression.
Article
Clinical Neurology
Anthony N. Cutrupi, Ramesh K. Narayanan, Gonzalo Perez-Siles, Bianca R. Grosz, Kaitao Lai, Alexandra Boyling, Melina Ellis, Ruby C. Y. Lin, Brent Neumann, Di Mao, Motonari Uesugi, Garth A. Nicholson, Steve Vucic, Mario A. Saporta, Marina L. Kennerson
Summary: This study identifies a novel gene-intergenic fusion transcript (UBE3C-IF) associated with distal hereditary motor neuropathy 1 (DHMN1). The UBE3C-IF transcript leads to decreased UBE3C protein levels in DHMN1 patient-derived motor neurons and causes synaptic transmission deficits and susceptibility to heat stress in a Caenorhabditis elegans model.
Article
Biochemistry & Molecular Biology
Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Han
Summary: Mounting evidence suggests that Lactobacillus paracasei-derived extracellular vesicles (Lpc-EV) can modify amyloid-beta (Aβ)-induced transcriptional changes and Aβ pathology in the brains of Tg-APP/PS1 mice. Lpc-EV treatment reverses Aβ-induced downregulation of neurotrophic factors and Aβ-degrading proteases, and mitigates cognitive decline in Tg-APP/PS1 mice.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Ya Shao, Tianbo Xu
Summary: This study found that miR-206-3p is involved in the neuroprotective effect of AD mice by regulating BDNF. Intervening with miR-206-3p mimics led to increased expression of miR-206-3p, improving cognitive and motor function in AD mice, promoting the recovery of neuron morphology, and increasing the expression of BDNF protein.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Clinical Neurology
Jules S. Mitchell, Daniel F. Hermens, Maxwell R. Bennett, Adem T. Can, Jim Lagopoulos
Summary: Anorexia nervosa is a disorder with poor treatment effectiveness, characterized by restrictive eating behaviors, distorted body image perceptions, and excessive physical activity. There is growing recognition of the underlying dysfunction in excitatory and inhibitory neurometabolite metabolism and signaling in anorexia nervosa. This review examines the role of N-methyl-d-aspartate receptor-mediated neurometabolite dysfunction in anorexia nervosa and discusses the potential use of zinc supplementation and low-dose ketamine in normalizing this dysfunction.
Article
Psychiatry
Jaakko Uotila, David Gyllenberg, Laura Korhonen, Susanna Hinkka-Yli-Salomaki, Emmi Heinonen, Roshan Chudal, Mika Gissler, Andre Sourander
Summary: The study found that the incidence of DBDs was higher in boys than girls, but the yearly incidence during adolescence was similar between genders; children with DBD tended to have parents with lower educational levels and were often diagnosed with other psychiatric disorders.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2021)
Editorial Material
Pediatrics
Laura Korhonen
Letter
Pediatrics
Laura Korhonen
Review
Cell Biology
Kid Tornquist, Muhammad Yasir Asghar, Vignesh Srinivasan, Laura Korhonen, Dan Lindholm
Summary: SARS-CoV-2 virus enters cells through binding with ACE2 protein and specific protease priming, while sphingolipids affect the uptake of virus particles. Inhibition of ASM function and S1P levels may be related to disease severity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nursing
Jenny Ringblom, Marie Proczkowska, Laura Korhonen, Ingrid Wahlin
Summary: Parents of children experiencing emergence delirium often feel fear, insecurity, and guilt, but find relief in information and support from healthcare staff. Children themselves confirm the uncontrollable behavior described by parents.
SCANDINAVIAN JOURNAL OF CARING SCIENCES
(2022)
Article
Health Care Sciences & Services
Berit M. Gustafsson, Samina Steinwall, Laura Korhonen
Summary: This article describes the development of a multi-professional and multi-agency model, PLUSS, to facilitate care and interventions for preschoolers with neurodevelopmental difficulties. The evaluation of the model shows positive outcomes in terms of implementation, effectiveness, and participant satisfaction.
BMC HEALTH SERVICES RESEARCH
(2022)
Review
Psychology, Developmental
Erica Mattelin, Kristina Paidar, Natalie Soderlind, Frida Froberg, Laura Korhonen
Summary: The Nordic welfare model is often cited as an example of promoting health and wellbeing, even for vulnerable groups like refugee children. However, there is a lack of published reviews on the resilience and risk and protective factors for the physical and mental health of refugee children in Nordic countries. This systematic review indicates the need for well-designed and powered studies to examine health outcomes and resilience among refugee children in the Nordic countries.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Berit M. Gustafsson, Laura Korhonen
Summary: The PLUSS model is an integrative working model that aims to provide coordinated services for preschool children with neurodevelopmental problems and their parents. This research project aims to investigate and evaluate the effectiveness of the model, user satisfaction, and implementation.
JMIR RESEARCH PROTOCOLS
(2022)
Editorial Material
Cell Biology
Lucia Sedlackova, Tetsushi Kataura, Sovan Sarkar, Viktor I. Korolchuk
Summary: Age-related human pathologies present with a multitude of molecular and metabolic phenotypes, which contribute to tissue degeneration. Lack of understanding of the interdependence of these molecular pathologies limits therapeutic intervention strategies. In this study, we investigate the molecular events underlying cellular viability loss in autophagy deficiency associated with aging and age-related disease. We discover a novel axis linking autophagy and a metabolite, NAD, which mediates cellular demise. By elucidating the steps from mitochondrial recycling to NAD maintenance, we identify targets for therapeutic interventions in autophagy dysfunction.
Review
Medicine, General & Internal
Gabriel Otterman, Ulugbek Nurmatov, Ather Akhlaq, Aideen Naughton, Alison Mary Kemp, Laura Korhonen, Andreas Jud, Mary Jo Vollmer Sandholm, Eva Mora-Theuer, Sarah Moultrie, Martin Chalumeau, Wouter A. Karst, Jordan Greenbaum
Summary: This study aims to assess the quality and clarity of guidelines on childhood sexual abuse issued by government agencies and academic societies in the European region, and compare them with the WHO guidelines. The study will retrieve and evaluate guidelines published by national governmental agencies or academic societies in 34 network countries, and provide statistical results on the content and consistency of the guidelines. Rating: 8/10.
Editorial Material
Pediatrics
Laura Korhonen
Article
Sport Sciences
Moa Jederstrom, Sara Agnafors, Christina L. Ekegren, Kristina Fagher, Hakan Gauffin, Laura Korhonen, Jennifer Park, Armin Spreco, Toomas Timpka
Summary: This study aims to investigate anxiety and depression in competitive figure skaters and identify associated factors. A cross-sectional study was conducted among 400 figure skaters in Southeast Sweden, finding that 47% exhibited anxiety and 10% exhibited depression. Overweight body image perception and older age were associated with anxiety. Further research on the mental health of figure skaters, especially those in need of assessment and support, is warranted.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Article
Medicine, General & Internal
Erica Mattelin, Frida Froberg, Laura Korhonen, Amal R. Khanolkar
Summary: The study shows that sexual and gender minority individuals have worse mental and general health regardless of their ethnic minority status. Immigrant and refugee sexual minority individuals have different trends in risky behaviors and experiences of violence compared to White sexual minority individuals and their heterosexual peers.
Article
Medicine, General & Internal
Erica Mattelin, Amal R. Khanolkar, Frida Froberg, Linda Jonsson, Laura Korhonen
Summary: This study aims to understand the mental health and social integration of adolescent and young adult migrants in Sweden, examining the impact of various factors through quantitative and qualitative analyses. The research will utilize multiple methods, including data analysis and narrative interviews, to explore individual experiences related to migration and exposure to violence.
Article
Sport Sciences
Moa Jederstrom, Sara Agnafors, Christina Ekegren, Kristina Fagher, Hakan Gauffin, Laura Korhonen, Jennifer Park, Armin Spreco, Toomas Timpka
Summary: A study on Swedish competitive figure skaters found that nearly one-third of young female skaters had experienced severe sports injuries in the past year, and one-fifth were currently dealing with ongoing injuries. Older age and inadequate food intake were identified as factors associated with sports injury occurrences.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)
