Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 8, Pages 4555-4561Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R113.481028
Keywords
Cardiovascular; Drug Development; Drug Discovery; Embryonic Stem Cell; Hepatocyte; Induced Pluripotent Stem Cells; Neurons; Stem Cells; Toxicology
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Toxicology has long relied on animal models in a tedious approach to understanding risk of exposure to an uncharacterized molecule. Stem cell-derived tissues can be made in high purity, quality, and quantity to enable a new approach to this problem. Currently, stem cell-derived tissues are primarily generic genetic backgrounds; the future will see the integration of various genetic backgrounds and complex three-dimensional models to create truly unique in vitro organoids. This minireview focuses on the state of the art of a number of stem cell-derived tissues and details their application in toxicology.
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