Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1

The future of epigenetic therapy in solid tumours—lessons from the past

(2013) Nilofer Azad et al.   Nature Reviews Clinical Oncology

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

DNA methylation inhibitors in cancer: Recent and future approaches

(2012) Christina Gros et al.   BIOCHIMIE

Pioglitazone, a PPAR  Agonist, Suppresses CYP19 Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1

(2012) K. Subbaramaiah et al.   Cancer Prevention Research

Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells

(2012) Marumi Ohno et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development

(2011) Alexandre Ceccaldi et al.   CHEMBIOCHEM

Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome

(2011) Shabana I. Khan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract

(2011) Carlota Oleaga et al.   EUROPEAN JOURNAL OF NUTRITION

The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1

(2011) Farisa Syeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS

(2011) Yongguang Tao et al.   NUCLEIC ACIDS RESEARCH

Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

(2011) Trenton L. Place et al.   PLoS One

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of epigenetic transcription repression and DNA methyltransferases in cancer

(2010) Filipe Ivan Daniel et al.   CANCER

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

A real-time assay for CpG-specific cytosine-C5 methyltransferase activity

(2010) Robert J. Wood et al.   NUCLEIC ACIDS RESEARCH

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Pharmacologic Unmasking of Epigenetically Silenced Genes in Breast Cancer

(2009) K. L. Ostrow et al.   CLINICAL CANCER RESEARCH

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

(2009) Jarosław Paluszczak et al.   TOXICOLOGY LETTERS

CpG island methylator phenotype (CIMP) in cancer: Causes and implications

(2008) Jens M. Teodoridis et al.   CANCER LETTERS

A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas

(2008) Emilia Wiechec et al.   GENES CHROMOSOMES & CANCER

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER