Ligand Binding to Anion-binding Exosites Regulates Conformational Properties of Thrombin

Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism

(2012) Austin D. Vogt et al.   BIOCHEMISTRY

The Dynamic Structure of Thrombin in Solution

(2012) Brian Fuglestad et al.   BIOPHYSICAL JOURNAL

Conformational selection in trypsin-like proteases

(2012) Nicola Pozzi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin

(2012) Harlan N. Bradford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities

(2012) P. M. Gasper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of Conformational Sampling in Ubiquitin

(2011) David Ban et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin

(2011) Preetpal Singh Sidhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thrombin Inhibition by Serpins Disrupts Exosite II

(2010) Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States

(2010) Parvathi Kamath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

(2010) Prafull S. Gandhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

(2010) Wolfram Bode et al.   PROTEIN SCIENCE

The effects of exosite occupancy on the substrate specificity of thrombin

(2009) Natasha May-Yoke Ng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biophysical Investigation of GpIbα Binding to Thrombin Anion Binding Exosite II

(2009) T. Michael Sabo et al.   BIOCHEMISTRY

Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

(2009) Nicolas S. Petrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of thrombomodulin activation of slow thrombin

(2009) T. E. ADAMS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinogen-elongated γ Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors

(2008) Stefano Lancellotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin

(2008) Enrico Di Cera   MOLECULAR ASPECTS OF MEDICINE

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE