Review
Physiology
Rongsong Li, Yang Xiao, Kang Li, Ling Tian
Summary: This review summarizes the recent research on autophagy regulated at both transcriptional and post-translational levels by insect hormone in cooperation with other signals, such as nutrient, in insects, providing a reference and deeper understanding for studying autophagy in insects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yan Gao, Xinlei Sheng, Doudou Tan, SunJoo Kim, Soyoung Choi, Sanjita Paudel, Taeho Lee, Cong Yan, Minjia Tan, Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki, He Huang, Yingming Zhao, Sangkyu Lee
Summary: This study identifies acetoacetate as the precursor for lysine acetoacetylation (Kacac), a previously uncharacterized histone post-translational modification. It also finds that HBO1 can function as both an acetyltransferase and an acetoacetyltransferase. Additionally, 33 Kacac sites are identified on mammalian histones, providing insight into the distribution of this modification across species and organs.
Article
Biochemical Research Methods
Sony Shrestha, Amuza Byaruhanga Lucky, Awtum Marie Brashear, Xiaolian Li, Liwang Cui, Jun Miao
Summary: This study profiled the histone post-translational modifications (PTMs) in the development of Plasmodium falciparum gametocytes, revealing novel PTM sites and distinct patterns from asexual stages. The results suggest that these PTMs play critical roles in gametocyte development and provide insights into the epigenetic regulation in the life cycle of the malaria parasite.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Medicine, Research & Experimental
Dongze Li, Li Zhang, Yanqiu He, Tingting Zhou, Xi Cheng, Wei Huang, Yong Xu
Summary: Diabetes is a prevalent global epidemic disease that is influenced by genetic, environmental, and socioeconomic factors. Histone post-translational modifications, specifically methylation and acetylation, play significant roles in the pathophysiological changes associated with diabetes. Recent advancements in mass spectrometry have identified novel histone acylation modifications, which are yet to be thoroughly investigated for their connection to diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Plant Sciences
William Agbemafle, Min May Wong, Diane C. Bassham
Summary: This review summarizes key regulatory mechanisms for modulating autophagy through post-translational modification or transcriptional regulation. Plants activate cellular responses to adapt to changing environmental conditions, one of which is autophagy, where cellular components are delivered to the vacuole for degradation. Autophagy is activated by various conditions, and the pathways controlling its activation are being elucidated. However, there is still much to discover regarding how these factors work together to properly modulate autophagy in response to specific signals.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Analytical
Ning Xia, Ting Sun, Lin Liu, Linxu Tian, Zhifang Sun
Summary: The study introduces a novel sensing platform utilizing avidin-modified interface and biotin-labeled substrates as probes for heterogeneous analysis, combining the advantages of homogeneous and heterogeneous assays while overcoming their limitations.
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Elena Kunadis, Eleftheria Lakiotaki, Penelope Korkolopoulou, Christina Piperi
Summary: Glioblastoma is the most common primary brain tumor in adults, characterized by variable histopathology, aggressiveness, and poor clinical outcomes. Epigenetic modifications play a crucial role in GBM research, providing a potential for tumor classification and prognosis, as well as for drug targeting. Recent advances in glioma epigenetic research focus on histone modifications and the use of epigenetic therapy as a valid treatment option for glioblastoma.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Microbiology
Samantha N. Cobos, Chaim Janani, Gabriel Cruz, Navin Rana, Elizaveta Son, Rania Frederic, Jailene Paredes Casado, Maliha Khan, Seth A. Bennett, Mariana P. Torrente
Summary: In this study, the researchers explore the link between prion states and histone modifications in yeast. They find that different prion states are associated with specific changes in histone post-translational modifications. These findings provide novel insights into the function of prions in yeast.
Article
Biochemistry & Molecular Biology
Karlie R. Platz, Emma J. Rudisel, Katelynn V. Paluch, Taylor R. Laurin, Kristin E. Dittenhafer-Reed
Summary: The mitochondrial proteome undergoes various post-translational modifications, and this study focused on the effects of acetylation and phosphorylation on the function of mitochondrial RNA polymerase (POLRMT). While some modifications showed slight decrease in the binding ability of POLRMT, there were minimal biological impacts observed in terms of viability, mtDNA content, and mitochondrial transcript levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Naoe Taira Nihira, Yoshio Miki
Summary: This article discusses the mechanisms by which tumor cells acquire immune tolerance through inhibiting T-cell activation and function, as well as the successes and limitations of immunotherapy targeting immune checkpoint molecules. The article highlights the importance of post-translational modifications in modulating the function of inhibitory immune checkpoint molecules.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Patricia Pascual-Vargas, Patricia C. Salinas
Summary: The Wnt pathway regulates the formation and function of neuronal circuits through Frizzled receptors, with aberrant signaling linked to synaptic defects and neurodegenerative diseases. The localization and stability of Fzd receptors are crucial for determining Wnt function, with post-translational modifications playing a key role. However, only phosphorylation and glycosylation have been studied as mechanisms for modulating Fzd function in the central nervous system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Chia-Wen Wang, Huai-Chia Chuang, Tse-Hua Tan
Summary: ACE2 serves as a counter regulator of the renin-angiotensin system and provides protection against chronic diseases. It is also the host receptor for SARS-CoV or SARS-CoV-2 virus, mediating virus infection. Understanding the regulation and modification of ACE2 may aid in developing prevention or treatment strategies for ACE2-mediated diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Zhe Li, Chunjing Cai, Xuexue Huo, Xuan Li, Zhong Lin
Summary: The study found that the SNF1-GCN5 cascade plays a crucial role in regulating cellulase production in Trichoderma viride by promoting altered histone acetylation. This finding offers a theoretical basis for optimizing T. viride in industrial cellulolytic enzyme production.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Oncology
Roberta Noberini, Evelyn Oliva Savoia, Stefania Brandini, Francesco Greco, Francesca Marra, Giovanni Bertalot, Giancarlo Pruneri, Liam A. McDonnell, Tiziana Bonaldi
Summary: This study simplified the protein extraction process from low-amount clinical samples and developed a protocol that allows MS-based analysis of histone PTMs from laser microdissected tissue areas with as low as 1000 cells, which is approximately 500 times lower than what is required by available methods. This method opens the possibility for spatial epi-proteomics, facilitating the investigation of epigenetic features in tissue and tumor heterogeneity and aiding in the discovery of novel epigenetic biomarkers and mechanisms.
CLINICAL EPIGENETICS
(2021)
Article
Plant Sciences
Qinghua He, Joel Dewei Toh, Rya Ero, Zhu Qiao, Veerendra Kumar, Aida Serra, Jackie Tan, Siu Kwan Sze, Yong-Gui Gao
Review
Biochemistry & Molecular Biology
Yong Qin Koh, Chia Jie Tan, Yi Long Toh, Siu Kwan Sze, Han Kiat Ho, Charles L. Limoli, Alexandre Chan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemical Research Methods
Xue Guo, Jung Eun Park, Xavier Gallart-Palau, Siu Kwan Sze
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Biochemical Research Methods
Siu Kwan Sze, Gnanasekaran JebaMercy, SoFong Cam Ngan
Summary: Deamidation is a degenerative protein modification that disrupts protein structure and function, playing a critical role in human aging and degenerative diseases. However, the study of deamidation has been limited by technical challenges in complex biological samples. New technologies, such as mixed mode electrostatic-interaction modified hydrophilic interaction liquid chromatography (emHILIC), are being developed to overcome these challenges and accurately analyze protein deamidation in complex samples.
Article
Multidisciplinary Sciences
Selvam Paramasivan, Sunil S. Adav, SoFong Cam Ngan, Rinkoo Dalan, Melvin Khee-Shing Leow, Hee Hwa Ho, Siu Kwan Sze
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Xavier Gallart-Palau, Xue Guo, Aida Serra, Siu Kwan Sze
ALZHEIMERS RESEARCH & THERAPY
(2020)
Article
Cell Biology
Chee Fan Tan, Hui San Teo, Jung Eun Park, Bamaprasad Dutta, Shun Wilford Tse, Melvin Khee-Shing Leow, Walter Wahli, Siu Kwan Sze
Article
Chemistry, Multidisciplinary
Ser Sue Ng, Jung Eun Park, Wei Meng, Christopher P. Chen, Raj N. Kalaria, Neil E. McCarthy, Siu Kwan Sze
Article
Chemistry, Physical
Xinya Hemu, Abbas El Sahili, Side Hu, Xiaohong Zhang, Aida Serra, Boon Chong Goh, Dina A. Darwis, Ming Wei Chen, Siu Kwan Sze, Chuan-fa Liu, Julien Lescar, James P. Tam
Article
Oncology
Shun Wilford Tse, Chee Fan Tan, Jung Eun Park, JebaMercy Gnanasekaran, Nikhil Gupta, Jee Keem Low, Kheng Wei Yeoh, Wee Joo Chng, Chor Yong Tay, Neil E. McCarthy, Sai Kiang Lim, Siu Kwan Sze
Article
Biochemistry & Molecular Biology
Ze Qin Lim, Qing Yong Ng, Yukei Oo, Justin Jang Hann Chu, Shi Yan Ng, Siu Kwan Sze, Sylvie Alonso
Summary: PRPH plays a crucial role in EV-A71 infection by facilitating viral entry and influencing viral genome replication. The ability of EV-A71 to exploit PRPH for successful invasion of the central nervous system represents a unique attribute, with small GTP-binding protein Rac1 potentially serving as a druggable host target to limit neuroinvasion.
Article
Chemistry, Multidisciplinary
Uthra Balasubramaniyan Iyer, Jung Eun Park, Siu Kwan Sze, Zbynek Bozdech, Mark Featherstone
Summary: This study provides physical evidence for the presence of the Mediator complex in Plasmodium falciparum and identifies several interaction partners that play important roles in gene expression and mRNA processing. The study also suggests a possible crosstalk between endoplasmic reticulum function and the transcriptional machinery.
Article
Cell Biology
Juliane O. Viegas, Gajendra Kumar Azad, Yuan Lv, Lior Fishman, Tal Paltiel, Sundararaghavan Pattabiraman, Jung Eun Park, Daniel Kaganovich, Siu Kwan Sze, Michal Rabani, Miguel A. Esteban, Eran Meshorer
Summary: CAPRIN1 is a factor that regulates an RNA degradation pathway in embryonic stem cells, and it has significant effects on early differentiation and gene expression programs.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Jose Antonio Sanchez Milan, Maria Fernandez-Rhodes, Xue Guo, Maria Mulet, SoFong Cam Ngan, Ranjith Iyappan, Maryam Katoueezadeh, Siu Kwan Sze, Aida Serra, Xavier Gallart-Palau
Summary: This study provides a comprehensive analysis of the impact of oxidative stress and phosphorylation on the aging process. The results show that trioxidized cysteine residues accumulate in the aging proteome and interact with enzymes involved in phosphorylation signaling, altering their structures in a similar way to phosphorylated serine residues. These findings are significant for understanding the interplay between oxidative stress and phosphorylation in aging, and open new avenues for research on protein modifications in chronic diseases and aging.
Review
Geriatrics & Gerontology
Sunil S. Adav, Siu Kwan Sze