Article
Environmental Sciences
Yang Yang, Yajing Feng, Hui Huang, Liuxin Cui, Fuqin Li
Summary: In this study, PM2.5 exposure was found to have negative effects on sperm quality and serum testosterone levels in male rats, while the IRE1 inhibitor STF083010 showed significant improvement in these effects. These findings suggest that the reproductive injury induced by PM2.5 may be mediated through the IRE1/JNK/autophagy signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Lei Yu, Yuxi Chen, Shaohui Yuan, Yang Cao, Zhenggang Bi
Summary: Peiminine suppressed proliferation and metastasis, induced cell cycle arrest, apoptosis, and autophagy in osteosarcoma cells, depending on intracellular ROS generation and JNK pathway activation. Furthermore, peiminine significantly inhibited xenograft tumor growth in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xian Jiang, Richard Sando, Thomas C. Sudhof
Summary: The study revealed that interference with microtubules or actin filaments, JNKs, PKA, or AKT signaling pathways can affect heterologous synapse formation, with JNK and PKA inhibitors suppressing both pre- and postsynaptic specialization formation, while AKT inhibitors only impairing postsynaptic specialization formation. By targeting PTEN, an enzyme regulating AKT activation, to postsynaptic sites, a decrease in excitatory synapse function was observed, indicating a multifaceted and multistage kinase network underlying heterologous synapse formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Huiai Lu, Chunlei Mei, Luhao Yang, Junyan Zheng, Junwei Tong, Fengsen Duan, Huageng Liang, Ling Hong
Summary: According to the study, PPM-18 induces autophagy and apoptosis in bladder cancer cells through activating the AMPK pathway, and it also accumulates reactive oxygen species (ROS) via ROS pathways to induce autophagy and apoptosis in bladder cancer cells, showing potential anticancer effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Christopher Xie, Dipon K. Mondal, Mikdat Ulas, Thomas Neill, Renato Iozzo
Summary: Decorin is a prototype member of the small leucine-rich proteoglycan gene family derived from stromal cells. It functions as a regulator of collagen fibrillogenesis and TGF-beta activity, and also acts as a pan-receptor tyrosine kinase (RTK) inhibitor. Decorin binds to various RTKs and transiently activates them, suppressing downstream signaling cascades and leading to growth inhibition. Decorin also restricts cancer growth and dissemination by impeding angiogenesis and inducing endothelial cell autophagy. Overall, decorin has the potential to be used as a protein-based adjuvant therapy to combat cancer.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Mukulika Bose, Priyanka Grover, Alexa J. Sanders, Ru Zhou, Mohammad Ahmad, Sophia Shwartz, Priyanka Lala, Sritama Nath, Mahboubeh Yazdanifar, Cory Brouwer, Pinku Mukherjee
Summary: This study finds that MUC1 plays a significant role in the development of pancreatic ductal adenocarcinoma (PDA). Overexpression of MUC1 activates the JNK pathway and increases cell viability. Conversely, low expression of MUC1 allows TGF-beta to retain its tumor-suppressive function. These findings contribute to a better understanding of the mechanisms behind PDA development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Xiang Gao, Miao Yu, Wenchang Sun, Yarao Han, Jinghua Yang, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Summary: Autophagy is a lysosome dependent degradation pathway in eukaryotic cells that plays a crucial role in cell balance and survival. Lanthanum (La), a rare earth element, has been shown to induce abnormal autophagy in rat hippocampus by affecting signaling pathways, leading to neuronal damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Fan Yang, Elyce Ozols, Frank Y. Ma, Khai Gene Leong, Greg H. Tesch, Xiaoyun Jiang, David J. Nikolic-Paterson
Summary: The JNK signaling pathway plays a role in acute high dose AA-induced kidney injury, but is not essential in promoting chronic kidney disease caused by ongoing DNA damage from chronic low dose AA exposure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Summary: The ethanol extract of Selaginella tamariscina (STE) has been found to exhibit neuroprotective effects by reducing oxidative stress and inhibiting autophagic cell death induced by glutamate in HT22 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jing-jing Liu, Jian-cheng Lin, Li-na Chen
Summary: This study found that HSP40 activates the immune response of human DCs through the TLR4-dependent p38 MAPK and JNK signaling pathways.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Oncology
Weixiao An, Yuxi Zhang, Honglin Lai, Yangyang Zhang, Hongmei Zhang, Ge Zhao, Minghua Liu, Yang Li, Xiukun Lin, Shousong Cao
Summary: This study found that Alpinia katsumadai Hayata (AKH) can inhibit cancer cell growth and induce apoptosis and autophagy. It exerts its effects by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways.
Article
Food Science & Technology
Yifeng Zhu, Heng Wang, Jianping Wang, Shunshun Han, Yao Zhang, Menggen Ma, Qing Zhu, Keying Zhang, Huadong Yin
Summary: This study investigated the effects of Zearalenone (ZEA) on chicken granulosa cells and found that ZEA inhibited cell growth by inducing apoptosis and promoting autophagy. Autophagy delayed apoptosis in ZEA-treated cells, reducing cytotoxicity. The results also showed that ZEA stimulated autophagy through PI3K-AKT-mTOR and MAPK signaling pathways in chicken granulosa cells.
Article
Chemistry, Medicinal
Mengjiao Shi, Jian Zhang, Miaomiao Li, Yaping Zhao, Ying Guo, Jiayi Xu, Rongrong Liu, Zongfang Li, Dongmei Ren, Pengfei Liu
Summary: This study investigated the protective effects of liquiritigenin (LQ), a natural flavonoid, against oxidative hepatotoxicity and the underlying mechanism. It was found that LQ eliminated reactive oxygen species in liver cells through NRF2 activation, involving both canonical and non-canonical signaling pathways. LQ-induced NRF2 activation was partially dependent on KEAP1-C151 and was also mediated by the blockage of autophagic flux and upregulation of p62, which competitively bound with KEAP1. Overall, this study reveals a novel molecular mechanism underlying the hepatoprotection of LQ, providing new insights into the pathogenesis and therapeutic strategies for oxidative liver injury.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Adnan Siddiqui, Sushovita Mukherjee, Praveen Manivannan, Krishnamurthy Malathi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Virology
Akatsuki Saito, Damien Ferhadian, Gregory A. Sowd, Erik Serrao, Jiong Shi, Upul D. Halambage, Samantha Teng, Juan Soto, Mohammad Adnan Siddiqui, Alan N. Engelman, Christopher Aiken, Masahiro Yamashita
JOURNAL OF VIROLOGY
(2016)
Article
Virology
Akatsuki Saito, Matthew S. Henning, Erik Serrao, Brittany N. Dubose, Samantha Teng, Jing Huang, Xiangming Li, Namiko Saito, Saumendra Prasad Roy, Mohammad Adnan Siddiqui, Jinwoo Ahn, Moriya Tsuji, Theodora Hatziioannou, Alan N. Engelman, Masahiro Yamashita
JOURNAL OF VIROLOGY
(2016)
Article
Biochemistry & Molecular Biology
Shubham Dayal, Jun Zhou, Praveen Manivannan, Mohammad Adnan Siddiqui, Omaima Farid Ahmad, Matthew Clark, Sahezeel Awadia, Rafael Garcia-Mata, Lirim Shemshedini, Krishnamurthy Malathi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Mohammad Adnan Siddiqui, Krishnamurthy Malathi
Article
Microbiology
Krishnamurthy Malathi, Mohammad Adnan Siddiqui, Shubham Dayal, Merna Naji, Heather J. Ezelle, Chun Zeng, Aimin Zhou, Bret A. Hassel
Article
Virology
Praveen Manivannan, Mohammad Adnan Siddiqui, Krishnamurthy Malathi
JOURNAL OF VIROLOGY
(2020)
Article
Microbiology
Mohammad Adnan Siddiqui, Masahiro Yamashita
Summary: This study demonstrates that coexisting innate immune stimuli can enhance the type I interferon response to HIV-1 infection through activation of a secondary signaling pathway, involving cGAS and TLR4, implying a complex interaction between different innate immune recognition pathways during HIV-1 infection.
Article
Biochemistry & Molecular Biology
Yang Xu, Tammy Ferguson, Kazuya Masuda, Mohammad Adnan Siddiqui, Kelsi Poole Smith, Olivia Vest, Brad Brooks, Ziyou Zhou, Judy Obliosca, Xiang-Peng Kong, Xunqing Jiang, Masahiro Yamashita, Tsuji Moriya, Christopher Tison
Summary: Luna Labs is developing a short carbon nanotube-based delivery platform called NanoVac, which can efficiently co-deliver mRNA and HIV-1 glycoproteins to the immune system with negligible toxicity. NanoVac stabilized the loaded mRNA and reduced the cold chain burden for vaccine deployment.