Article
Chemistry, Multidisciplinary
Jiawen Gong, Quan Liu, Linlin Cai, Qi Yang, Yuping Tong, Xi Chen, Sumasri Kotha, Xiaobo Mao, Weiwei He
Summary: Salt stress is a major environmental challenge that affects global crop yield. In this study, carbon dot nanozymes (CDzymes) derived from glucose and histidine are developed to alleviate salt-induced oxidative stress in plants. CDzymes exhibit strong antioxidant activity and multiple mechanisms of action. They show good biocompatibility and can enhance plant growth under salinity. CDzyme treatment effectively reduces salt stress-induced oxidative damage and improves redox enzyme activity. This study presents CDzymes as a potential antioxidant for managing salt stress in crops.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Yao Xiao, Lujie Ren, Yanan Wang, Huanhuan Wen, Yongqiang Ji, Chenshou Li, Yangqing Yi, Caiying Jiang, Qing Sheng, Zuoming Nie, Qixiang Lu, Zhengying You
Summary: The structure and expression characteristics of the silkworm GRP78 protein were investigated in this study. BmGRP78 was found to be widely expressed in different tissues and developmental stages of the silkworm, and its expression level was upregulated under heat induction and Pb/Hg exposure, but not affected by BmNPV infection. Furthermore, BmGRP78 was observed to translocate into the nucleus after exposure to heat, Pb, Hg, and BmNPV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jun Chul Park, Jae-Seong Lee
Summary: Continuous evolution of omics technologies has facilitated the identification of important gene families, with recent research focusing on detoxification-related gene families in widely used ecotoxicological model species. While heat shock proteins (Hsps) play crucial roles in cellular functions and stress responses, comprehensive genome-wide identification of Hsps, especially in aquatic invertebrates, remains limited. This study reports the complete Hsps and basal gene expression levels in three region-specific copepods, shedding light on the regulation of each Hsp family gene at a basal level.
MARINE POLLUTION BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Venugopalan Visha Kumari, Purabi Banerjee, Vivek Chandra Verma, Suvana Sukumaran, Malamal Alickal Sarath Chandran, Kodigal A. Gopinath, Govindarajan Venkatesh, Sushil Kumar Yadav, Vinod Kumar Singh, Neeraj Kumar Awasthi
Summary: By 2050, the global population is expected to reach 9-10 billion, leading to an increased demand for food in many countries. Various abiotic stresses such as temperature, soil salinity, and moisture have negative effects on plant growth and development at different levels. Plant nutrition proves to be an effective strategy to mitigate abiotic stresses in crops. This article discusses the effectiveness of different nutrients in alleviating abiotic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Yao Liu, Hehe Yang, Fang Wen, Liangliang Bao, Zhihong Zhao, Zhimei Zhong
Summary: In nature, extreme environmental conditions can lead to irreversible damage to plants. However, intervention with phytostimulants, such as proteins and polysaccharides, can improve plant stress resistance without causing damage to the plants themselves, thereby maintaining production. Chitooligosaccharide, a plant stimulant, has been shown to promote seed germination, plant growth and development, and improve plant photosynthesis. This review summarizes the progress in research on chitooligosaccharide-induced plant stress resistance, including the mechanisms and experiments related to resistance against pathogens, drought, low-temperature, saline-alkali, and other stresses. The review also highlights the challenges and the need for multidisciplinary cooperation in future research on chitooligosaccharide's effects on plants.
CARBOHYDRATE POLYMERS
(2023)
Article
Cell Biology
Yuemei Zhang, Yu Wang, Wenxu Wen, Zhengrong Shi, Qinsheng Gu, Golam Jalal Ahammed, Kai Cao, Mohammad Shah Jahan, Sheng Shu, Jian Wang, Jin Sun, Shirong Guo
Summary: Spermidine regulates salt tolerance and autophagy in cucumber by activating ATG genes and autophagosomes formation, mediated through NADPH oxidase-derived apoplastic H2O2.
Article
Plant Sciences
Ana P. Santos, Carolina Belfiore, Cristina Urbez, Alejandro Ferrando, Miguel A. Blazquez, Maria E. Farias
Summary: This study found that bacteria from extreme environments can promote plant growth and enhance the tolerance of soybean plants to salt stress. These bacteria not only increased the germination rate of soybeans but also doubled the length and dry biomass of soybean roots under salt stress. Additionally, the presence of these bacteria resulted in changes in plant gene expression, particularly in genes related to growth and stress responses. This research suggests that these extremophilic bacteria could serve as potential bio-inoculants to alleviate salt stress and promote plant growth.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Pharmacology & Pharmacy
Zhiwei Huang, Hengcai Wang, Changju Chun, Xinze Li, Shihao Xu, Yingzheng Zhao
Summary: In this study, self-assembled nanoparticles comprising chitosan and heparin (CH) were developed to deliver FGF21 (CH-FGF21) for the treatment of liver diseases. CH-FGF21 effectively attenuated the oxidative damage and intracellular inflammation caused by APAP to hepatocytes. In a murine model of APAP-induced hepatotoxicity, CH-FGF21 could alleviate ALI progression and promote the recovery of liver function.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Changhui Liu, Zhisen Pan, Zhouli Wu, Kaijia Tang, Yadi Zhong, Yingjian Chen, Xiaoxia Xiao, Jingyi Guo, Siwei Duan, Tianqi Cui, Guangcheng Zhong, Zifeng Yang, Chong Zhong, Sheng Lin, Yong Gao
Summary: This study reveals the protective effects of SIRT6 and its mechanisms in defending against APAP-induced hepatotoxicity. SIRT6 expression is reduced in acute liver injury, and its deletion enhances liver injury by affecting glutathione and N-acetyl-p-benzoquinoneimine levels. Overexpression or activation of SIRT6 alleviates hepatotoxicity through normalization of liver damage, inflammation, and oxidative stress. SIRT6 regulates FXR and its activation mitigates hepatotoxicity. Pharmacological activation of SIRT6 may represent a novel therapeutic strategy for APAP overdose-induced liver injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Huijuan Zhang, Tiancong Song, Rui Kang, Feiyue Ren, Jie Liu, Jing Wang
Summary: The retina is an important tissue in the eye, and exposure to light can induce oxidative stress and inflammatory reactions in retinal cells, leading to retinal damage-related diseases and asthenopia. Plant bioactive compounds have antioxidant effects and can alleviate retinal damage and asthenopia. Understanding these mechanisms can better protect the retina and reduce asthenopia.
NUTRITION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Deyu Zhang, Shitai Zhang, Zheng He, Ying Chen
Summary: The study investigates the molecular mechanisms by which CpG-ODNs regulate the PARP1/XRCC1 signaling axis and its impact on radiation kidney injury (RKI) in cervical cancer radiotherapy. CpG-ODNs alleviate RKI by inhibiting DNA damage and oxidative stress levels. The study suggests that CpG-ODNs can mitigate cervical cancer RKI by blocking the activation of the PARP1/XRCC1 signaling axis, inhibiting DNA damage and oxidative stress response in renal tubule epithelial cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Adria Hasan, Suroor Fatima Rizvi, Sana Parveen, Snober S. Mir
Summary: Cells may undergo DNA damage due to various stressors, leading to altered cell function and diseases such as cancer. DNA repair mechanisms play a crucial role in maintaining genome stability, with heat shock proteins (HSPs) being key players in this adaptive response. Modulating protein quality control systems like the HSPs network could be a promising strategy for targeting diseases associated with genomic instability, such as cancer.
Article
Cell Biology
Kalina Timcheva, Solenne Dufour, Leila Touat-Todeschini, Callum Burnard, Marie-Christine Carpentier, Florent Chuffart, Remy Merret, Marion Helsmoortel, Sabrina Ferre, Aude Grezy, Yohann Coute, Sophie Rousseaux, Saadi Khochbin, Claire Vourc'h, Cecile Bousquet-Antonelli, Rosemary Kiernan, Daphne Seigneurin-Berny, Andre Verdel
Summary: Heat stress leads to changes in gene expression, and YTHDC1 plays a crucial role in this process. YTHDC1 redistributes across the genome and binds to m6A-modified transcripts, promoting the expression of heat shock proteins. Additionally, YTHDC1 interacts with m6A-modified non-coding RNAs in stress bodies, contributing to gene expression reprogramming.
Article
Environmental Sciences
Mahammed Moniruzzaman, Arpan Kumar Maiti, Suman Bhusan Chakraborty, Ishita Saha, Nimai Chandra Saha
Summary: This study investigated the effects of melatonin on attenuating LPS-induced oxidative damages in a zebrafish model. The results showed that melatonin treatment reduced oxidative stress and pro-inflammatory cytokines, protecting the brain from inflammation-induced damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Jaykumar Patel, Avinash Mishra
Summary: Water is a crucial resource for plant growth and development, but changes in climate, especially increased drought frequency and severity, have impacted agricultural productivity worldwide. Aquaporins, membrane channels in plants, play a vital role in regulating cellular water balance and osmotic homeostasis. Research has shown that aquaporins have significant effects on root structure, water uptake, photosynthesis, and other physiological processes in plants under water deficit conditions.
PHYSIOLOGIA PLANTARUM
(2021)
Review
Plant Sciences
Melissa A. Scranton, Joseph T. Ostrand, Francis J. Fields, Stephen P. Mayfield
Article
Biotechnology & Applied Microbiology
Melissa A. Scranton, Joseph T. Ostrand, D. Ryan Georgianna, Shane M. Lofgren, Daphne Li, Rosalie C. Ellis, David N. Carruthers, Andreas Draeger, David L. Masica, Stephen P. Mayfield
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2016)
Article
Multidisciplinary Sciences
Melissa A. Scranton, Jonathan H. Fowler, Thomas Girke, Linda L. Walling
Article
Biochemical Research Methods
Kevin Duprez, Melissa A. Scranton, Linda L. Walling, Li Fan
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2014)