Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Selective protein degradation in cell signalling

(2012) Han Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural variability of the ubiquitin specific protease DUSP-UBL double domains

(2011) Paul R. Elliott et al.   FEBS LETTERS

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Feedback Regulation of Ras Signaling by Rabex-5-Mediated Ubiquitination

(2010) Lizhong Xu et al.   CURRENT BIOLOGY

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Ubiquitin in NF-κB Signaling

(2009) Yu-Hsin Chiu et al.   CHEMICAL REVIEWS

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

(2009) G. Markson et al.   GENOME RESEARCH

KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs

(2009) J. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissection of USP catalytic domains reveals five common insertion points

(2009) Yu Ye et al.   Molecular BioSystems

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein partners of deubiquitinating enzymes

(2008) Karen H. Ventii et al.   BIOCHEMICAL JOURNAL

Signaling Threshold Regulation by the Ras Effector IMP

(2008) Sharon A. Matheny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21 Ras/Impedes Mitogenic Signal Propagation Regulates Cytokine Production and Migration in CD4 T Cells

(2008) Jan Czyzyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds

(2008) Chiyuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY