The Dok-3/Grb2 Protein Signal Module Attenuates Lyn Kinase-dependent Activation of Syk Kinase in B Cell Antigen Receptor Microclusters
Published 2012 View Full Article
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Title
The Dok-3/Grb2 Protein Signal Module Attenuates Lyn Kinase-dependent Activation of Syk Kinase in B Cell Antigen Receptor Microclusters
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 4, Pages 2303-2313
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2012-12-06
DOI
10.1074/jbc.m112.406546
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- B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster
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- Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction
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- Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells
- (2009) Niklas Engels et al. NATURE IMMUNOLOGY
- Early Events of B Cell Activation by Antigen
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- New Insights into the Early Molecular Events Underlying B Cell Activation
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- Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
- (2008) Michele Weber et al. JOURNAL OF EXPERIMENTAL MEDICINE
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