Native Mutant Huntingtin in Human Brain

Huntington's Disease: Advocacy Driving Science

(2011) Nancy S. Wexler   Annual Review of Medicine

A Compact β Model of huntingtin Toxicity

(2011) Qi Charles Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

(2011) Kimberly B Kegel et al.   Molecular Neurodegeneration

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Huntington's Disease

(2011) S. Finkbeiner   Cold Spring Harbor Perspectives in Biology

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

(2010) Christian Landles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Urea-Induced Unfolding of Na,K-ATPase As Evaluated by Electron Paramagnetic Resonance Spectroscopy

(2009) Mohammad Babavali et al.   BIOCHEMISTRY

Huntingtin facilitates polycomb repressive complex 2

(2009) Ihn Sik Seong et al.   HUMAN MOLECULAR GENETICS

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

(2009) Kirupa Sathasivam et al.   HUMAN MOLECULAR GENETICS

Polyglutamine expansion in huntingtin alters its interaction with phospholipids

(2009) Kimberly B. Kegel et al.   JOURNAL OF NEUROCHEMISTRY

Mutant huntingtin and glycogen synthase kinase 3-β accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease

(2009) Antonio Valencia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

SEA Domain Autoproteolysis Accelerated by Conformational Strain: Energetic Aspects

(2008) Anders Sandberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

Solubilization of membrane protein complexes for blue native PAGE

(2008) Veronika Reisinger et al.   Journal of Proteomics

Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm

(2008) Eliana Romero et al.   NEURON

Features and applications of blue-native and clear-native electrophoresis

(2008) Ilka Wittig et al.   PROTEOMICS