Article
Transplantation
Sergio C. Lopez-Garcia, Mallory L. Downie, Ji Soo Kim, Olivia Boyer, Stephen B. Walsh, Tom Nijenhuis, Svetlana Papizh, Pallavi Yadav, Ben C. Reynolds, Stephane Decramer, Martine Besouw, Manel Perello Carrascosa, Claudio La Scola, Francesco Trepiccione, Gema Ariceta, Aurelie Hummel, Claire Dossier, John A. Sayer, Martin Konrad, Mandy G. Keijzer-Veen, Atif Awan, Biswanath Basu, Dominique Chauveau, Leire Madariaga, Linda Koster-Kamphuis, Monica Furlano, Miriam Zacchia, Pierluigi Marzuillo, Yincent Tse, Ismail Dursun, Ayse Seda Pinarbasi, Despoina Tramma, Ewout J. Hoorn, Ibrahim Gokce, Kathleen Nicholls, Loai A. Eid, Lisa Sartz, Michael Riordan, Nakysa Hooman, Nikoleta Printza, Olivier Bonny, Pedro Arango Sancho, Raphael Schild, Rajiv Sinha, Stefano Guarino, Victo Martinez Jimenez, Lidia Rodriguez Pena, Hendrica Belge, Olivier Devuyst, Tanja Wlodkowski, Francesco Emma, Elena Levtchenko, Nine V. A. M. Knoers, Daniel G. Bichet, Franz Schaefer, Robert Kleta, European NDI Consortium, Detlef Bockenhauer
Summary: The study of a large NDI cohort showed overall favorable outcomes with normal adult height and mild to moderate chronic kidney disease. However, lower educational achievement and the presence of urological and mental health problems in over half of the patients were noted.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Helena Baechle, Peggy Sekula, Pascal Schlosser, Inga Steinbrenner, Yurong Cheng, Fruzsina Kotsis, Heike Meiselbach, Helena Stockmann, Sebastian Schoenherr, Kai-Uwe Eckardt, Olivier Devuyst, Juergen Scherberich, Anna Koettgen, Ulla T. Schultheiss
Summary: This study aimed to explore metabolites associated with uromodulin concentrations and evaluate their association with the progression of chronic kidney disease (CKD) and adverse kidney events. The study found that higher levels of urinary and serum uromodulin were associated with a lower risk of adverse kidney events, suggesting a potential protective role of functional nephrons in CKD outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Olivier Devuyst, Krzysztof Kiryluk
KIDNEY INTERNATIONAL
(2023)
Article
Physiology
Seraina O. Moser, Betuel Haykir, Catharina J. Kueng, Carla Bettoni, Nati Hernando, Carsten A. Wagner
Summary: The concentration of inorganic phosphate in plasma is controlled by hormones, and saliva glands have the ability to concentrate phosphate. The parotid glands preferentially use Slc20 for phosphate transport and are potential targets for regulation by PTH and vitamin D-3.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Editorial Material
Physiology
Carsten A. Wagner
Article
Medicine, General & Internal
Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, Nicole Graf, Suzan Dahdal, Daniel Sidler, Spyridon Arampatzis, Karine Hadaya, Thomas F. Mueller, Carsten A. Wagner, Rudolf P. Wuethrich
Summary: This study examined the effects of sodium bicarbonate treatment on graft function in kidney transplant recipients. The results showed that treatment with sodium bicarbonate for two years did not affect the decline in estimated glomerular filtration rate (GFR). Therefore, sodium bicarbonate treatment is not generally recommended for preserving GFR in kidney transplant recipients with chronic kidney disease and metabolic acidosis.
Editorial Material
Transplantation
Michele Farisco, Irene Zecchino, Giovambattista Capasso, CONNECT Consortium
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Ines P. D. Costa, Nicolas Hautem, Gugliemo Schiano, Shinichi Uchida, Tomoya Nishino, Olivier Devuyst
Summary: The study reveals that AQP1 and AQP7 are abundantly expressed in the peritoneal membrane. While AQP1 facilitates water transport during peritoneal dialysis, the role of AQP7 in glycerol transport during fasting is unknown. The findings show that fasting increases the expression of AQP1 and AQP7 in the peritoneum, leading to structural and functional changes that improve fluid removal.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Henrik Dimke, Camille Griveau, Wung-Man Evelyne Ling, Gaelle Brideau, Lydie Cheval, Pravina Muthan, Dominik Mueller, Amr Al-Shebel, Pascal Houillier, Caroline Prot-Bertoye
Summary: The kidney plays a critical role in maintaining mineral balance in the body. Dysregulation of calcium and magnesium reabsorption in the renal tubules can lead to familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), which is characterized by excessive wasting of calcium and magnesium. This study investigated the localization of claudin-19 (CLDN19), a protein involved in mineral reabsorption, in the kidneys and found that it is primarily located in the basolateral membrane of the renal tubules. Additionally, the study showed that CLDN19 interacts with claudin-16 (CLDN16) to regulate permeability in the tubules. These findings provide insights into the pathophysiology of FHHNC and highlight the importance of CLDN19 in maintaining mineral homeostasis in the kidney.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pedro Henrique Imenez Silva, Donald E. Wesson, Carsten A. Wagner
Summary: Chronic kidney disease (CKD) is a disease characterized by progressive decline in kidney function. Treatments that aim to stabilize or slow its progression can delay the need for kidney replacement therapy and reduce the mortality rate associated with reduced kidney function. Metabolic acidosis and less severe stages of the acid stress continuum are common in CKD, and studies have shown that correcting these conditions can slow the progression to end-stage kidney disease. This correction can be achieved through dietary changes, such as consuming fewer acid-producing foods or more base-producing foods, or through the use of mineral alkali or pharmacological approaches.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Review
Clinical Neurology
Marion Pepin, Aleksandra Klimkowicz-Mrowiec, Olivier Godefroy, Pilar Delgado, Sol Carriazo, Ana Carina Ferreira, Aleksandra Golenia, Jolanta Malyszko, Tomasz Grodzicki, Konstantinos Giannakou, Giuseppe Paolisso, Michelangela Barbieri, Liliana Garneata, Carmen Antonia Mocanu, Sophie Liabeuf, Goce Spasovski, Carmine Zoccali, Annette Bruchfeld, Ana Farinha, Mustafa Arici, Giovambattista Capasso, Andrzej A. Wiecek, Ziad Massy
Summary: Cognitive impairment is common in patients with chronic kidney disease (CKD). This article reviews interventions for the complications of CKD and prevention of vascular events, which may potentially also be protective against cognitive impairment. Nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize its impact on CKD patients' daily lives are discussed. It is necessary to conduct studies assessing the effect of interventions on the cognitive function of patients with CKD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Urology & Nephrology
Carsten A. Wagner, Robert Unwin, Sergio C. Lopez-Garcia, Robert Kleta, Detlef Bockenhauer, Stephen Walsh
Summary: This review discusses the underlying genetic and acquired causes of distal renal tubular acidosis (dRTA), a condition characterized by the failure to acidify urine below pH 5.5. Inherited forms of dRTA are caused by variants in specific genes such as SLC4A1 and ATP6V1B1, while acquired forms can result from autoimmune diseases or adverse drug effects. Incomplete dRTA, which is frequently found in patients with or without kidney stone disease, may represent an intermediate state in the ability to excrete acids. Untreated or unrecognized dRTA can lead to various complications such as rickets, osteomalacia, nephrolithiasis, and electrolyte disorders, and increase the risk of chronic kidney disease development.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
H. Vitzthum, M. Koch, L. Eckermann, S. L. Svendsen, P. Berg, C. A. Huebner, C. A. Wagner, J. Leipziger, C. Meyer-Schwesinger, H. Ehmke
Summary: Maintaining acid-base balance is important for the kidneys, and the solute transporter AE4 in beta-intercalated cells is found to play a role in renal acid-base sensing mechanism.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Nima Yassini, Janine Sprenger, Eva Maria Pastor Arroyo, Christiane Krudewig, Giovanni Pellegrini, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Summary: Ovarian cancer G protein-coupled receptor 1 (OGR1) and G protein-coupled receptor 4 (GPR4) play important roles in renal acid-base physiology, tissue inflammation, and fibrosis. In this study, the researchers found that OGR1 deficiency led to increased crystal deposition and impaired kidney function in mice with crystalline nephropathy. On the other hand, GPR4 deficiency did not have a significant impact on disease progression. These findings suggest that OGR1 may be important in limiting kidney crystal deposition and could be relevant to the pathophysiology of kidney stones.
Article
Endocrinology & Metabolism
Rocio Fuente, Eva-Maria Pastor-Arroyo, Nicole Gehring, Patricia Oro Carbajosa, Laura Alonso-Duran, Ivan Zderic, James Tapia-Dean, Ahmad Kamal Hamid, Carla Bettoni, Fernando Santos, Carsten A. Wagner, Isabel Rubio-Aliaga
Summary: This study examines the role of FGF23 signaling in growth plate metabolism and finds that a short C-terminal FGF23 fragment and modified peptides can improve growth and bone issues in XLH patients, enhancing growth rate and growth plate structure.
JOURNAL OF ENDOCRINOLOGY
(2023)