Identification of a Small Molecule That Modulates Platelet Glycoprotein Ib-von Willebrand Factor Interaction

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

(2011) H. Ulrichts et al.   BLOOD

Structural insight into brassinosteroid perception by BRI1

(2011) Ji She et al.   NATURE

Binding of von Willebrand Factor to Collagen and Glycoprotein Ibα, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice—Brief Report

(2010) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor

(2010) Laura B. Sheard et al.   NATURE

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo

(2010) Florian B. Mayr et al.   TRANSFUSION

Glycoprotein Ib  inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism

(2009) P. A. McEwan et al.   BLOOD

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

Anti-von Willebrand factor aptamer ARC1779 for refractory thrombotic thrombocytopenic purpura

(2009) Paul Knöbl et al.   TRANSFUSION

Identification of Peptide Antagonists to Glycoprotein Ibα That Selectively Inhibit von Willebrand Factor Dependent Platelet Aggregation

(2008) Susan Adam Benard et al.   BIOCHEMISTRY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Virtual Screening and Its Integration with Modern Drug Design Technologies

(2008) Adriano Andricopulo et al.   CURRENT MEDICINAL CHEMISTRY

Rational design of antithrombotic peptides to target the von Willebrand Factor (vWf) - GPIb integrin interaction

(2008) Carlos del Carpio Munoz et al.   JOURNAL OF MOLECULAR MODELING