Review
Urology & Nephrology
Frank C. Brosius, David Cherney, Patrick O. Gee, Raymond C. Harris, Alan S. Kliger, Katherine R. Tuttle, Susan E. Quaggin
Summary: Diabetes and its complications pose a severe threat to humankind, with diabetic kidney disease being one of the most devastating complications. Current treatment methods for diabetic kidney disease are limited, presenting challenges for both patients and healthcare providers. Recent advancements in therapies promise to transform care for patients with diabetes and kidney disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Transplantation
Rupert W. Major, David Shepherd, James F. Medcalf, Gang Xu, Laura J. Gray, Nigel J. Brunskill
Summary: South Asian individuals with chronic kidney disease are younger and have more advanced disease compared to White individuals, with a higher risk of end-stage renal disease but a lower mortality rate. Specific interventions tailored to the South Asian population, including the use of the CKD-EPI-PK formula, should be considered.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Clodagh Cogley, Claire Carswell, Kate Bramham, Joseph Chilcot
Summary: Individuals with severe mental illness have a higher risk of developing chronic kidney disease, partly due to known risk factors such as lithium treatment and cardiovascular disease. However, the reasons for the higher proportion of chronic kidney disease in this population still require further research. Similarly, there is a lack of data on the rates of severe mental illness in individuals with chronic kidney disease. Furthermore, individuals with severe mental illness and chronic kidney disease have poorer health outcomes and receive suboptimal kidney care. Education and closer collaboration between kidney healthcare staff and psychiatry may improve care for this population.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Shaoqing Gong, Kesheng Wang, Ying Li, Zhongliang Zhou, Arsham Alamian
Summary: This study examined the disparities in obesity among Asians living in California and found associations between ethnicity and obesity, suggesting interventions to reduce obesity disparities among Asian Americans.
Article
Pharmacology & Pharmacy
Silvana Nader Nagib, Saeed Abdelwahab, Ghada Essam El-Din Amin, Mohamed Farouk Allam
Summary: This study aimed to determine the prevalence and risk factors of CKD among hypertensive non-diabetic patients attending primary health care centers in Cairo. The study found that the prevalence of CKD among the hypertensive non-diabetic patients was 33%, and it is more common in females, those with primary education and low socioeconomic class, patients with positive family history of CKD, patients with ischemic heart disease, and those using antihypertensive drugs. CKD in these patients leads to significant morbidity and mortality.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Jennifer A. Hirst, Jose M. Ordonez Mena, Chris A. O'Callaghan, Emma Ogburn, Clare J. Taylor, Yaling Yang, F. D. Richard Hobbs
Summary: This study in UK primary care found a prevalence of over 70% for multimorbidity in patients with CKD and transient renal function impairment. Age, BMI, and eGFR were significantly associated with multimorbidity. Hypertension and obesity were the most common coexisting conditions among CKD patients.
Article
Endocrinology & Metabolism
Hakyung Kim, Jae Hyun Bae, Kyong Soo Park, Joohon Sung, Soo Heon Kwak
Summary: In an East Asian population, we identified 8 DMSs associated with T2D, including 5 novel CpG loci, and 3 DMSs associated with DKD at methylome-wide statistical significance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Simon Nusinovici, Charumathi Sabanayagam, Kristine E. Lee, Liang Zhang, Carol Y. Cheung, E. Shyong Tai, Gavin S. W. Tan, Ching Yu Cheng, Barbara E. K. Klein, Tien Yin Wong
Summary: The study found that retinal microvascular signs are associated with the development of diabetic kidney disease in Asian and White populations. The changes in retinal microvasculature may be a potential predictor for the occurrence of DKD.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Navdeep Tangri, Vandana Mathur, Nancy Reaven, Susan E. Funk, Donald E. Wesson
Summary: Metabolic acidosis is associated with chronic kidney disease (CKD) progression and mortality. The incidence of metabolic acidosis is higher in Asian, Black, and Hispanic individuals, but residing in higher education zip codes mitigates this risk. Metabolic acidosis is independently associated with adverse outcomes in CKD patients across all racial/ethnic groups.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Lingwang An, Qiuzhi Yu, Hong Tang, Xianglan Li, Dandan Wang, Qi Tang, Haiyang Xing, Yali He, Xiaona Zhao, Shuhui Zhao, Yaujiunn Lee, Juming Lu
Summary: This study evaluated the prevalence of chronic kidney disease (CKD) in Chinese adults with type 2 diabetes mellitus (T2DM) and investigated the association between ABC control (HbA(1c), blood pressure, and triglycerides) and the progression and regression of CKD. The results showed a high prevalence of CKD and a certain percentage of patients had an increased risk of CKD progression. The study also found a negative association between ABC control and CKD progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Hua Wang, Shu Zhang, Jia Guo
Summary: Research suggests that lipotoxicity plays a significant role in renal injury during the progression of diabetic nephropathy, primarily leading to glomerular dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yunfeng Bai, Ping Li, Jiaona Liu, Lu Zhang, Shaoyuan Cui, Cuiting Wei, Bo Fu, Xuefeng Sun, Guangyan Cai, Quan Hong, Xiangmei Chen
Summary: This study found that the number and length of renal cilia are significantly increased in diabetic kidney disease (DKD) patients, and are positively correlated with the severity of DKD. This finding was also confirmed in animal models. Therefore, renal cilia may serve as clinically relevant indicators and potential therapeutic targets for DKD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Seraphine Zeitouny, Lucy Cheng, Sabrina T. T. Wong, Mina Tadrous, Kimberlyn McGrail, Michael R. Law
Summary: This study aimed to investigate the reasons for patients not filling prescriptions and identify factors that contribute to primary nonadherence. The results showed that a significant proportion of prescriptions were not filled, particularly for drugs that are used on an as-needed basis, such as topical corticosteroids and antihistamines. Patient age and polypharmacy were also associated with primary nonadherence.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Primary Health Care
Clare MacRae, Stewart W. Mercer, Bruce Guthrie, David Henderson
Summary: This study examined the prevalence of comorbidities in adults with CKD in a large Scottish primary care population, and found that CKD patients had significantly higher rates of comorbidities across a wide range of physical and mental health conditions. Routine care for CKD patients should include recognition and management of comorbidities.
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Medical Laboratory Technology
Sushma Thimmaiah Kanakalakshmi, Shilna Muttickal Swaminathan, Pooja Basthi Mohan, Shankar Prasad Nagaraju, Mohan Bhojaraja, Sindhura Lakshmi Koulmane Laxminarayana
Summary: Diabetic kidney disease (DKD) is a common cause of renal failure in chronic kidney disease (CKD) patients. The limitations of current diagnostic markers call for the search of novel biomarkers. Microparticles, which play a role in cell-to-cell communication, show potential in early diagnosis and prognosis of DKD.
CLINICA CHIMICA ACTA
(2022)