Article
Multidisciplinary Sciences
Yu-Wei Zhou, Jie Sun, Ye Wang, Cai-Ping Chen, Tao Tao, Ming Ma, Xin Chen, Xue-Na Zhang, Li-Yuan Yang, Zhong-Liang Zhang, Ye-Qiong Li, Zhi-Hui Jiang, Tian-Tian Qiu, Han Wang, Yang Pan, Jian Zhang, Hua-Qun Chen, Pei Wang, Min-Sheng Zhu
Summary: Activation of bitter receptors can induce bronchodilation and inhibit pulmonary inflammation and tissue remodeling in COPD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Perez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A. Camargo, Kohei Hasegawa
Summary: Using tIgE and virus data, we identified phenotypes of infant bronchiolitis and studied their association with asthma development and biological characteristics. We found 4 phenotypes, and infants with the tIgE(high)virus(RSV-low/RV) phenotype had a significantly higher risk for developing asthma. These phenotypes also exhibited different biological characteristics, such as depleted type I interferon and enriched antigen presentation pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
Francesco Menzella, Jocelyne Just, Inessa Schwab Sauerbeck, Claudia Mailaender, Fabiana Saccheri, Celine Thonnelier, Xavier Jaumont, Laurence Mala
Summary: This review examines the clinical efficacy of omalizumab in patients with severe allergic asthma with IgE levels exceeding the current dosing range. The results of the reviewed studies involving more than 3000 patients demonstrate that omalizumab significantly reduces exacerbations, improves asthma control and lung function, and enhances quality of life in these patients. Omalizumab is well-tolerated and has demonstrated efficacy and safety in other comorbidities of asthma as well. A detailed assessment and a proposed management algorithm for treating severe allergic asthma patients with IgE levels >1500 IU/mL are provided.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiao-xi Hu, Ai-jun Zhang, Wen-wen Pan, Qian-ling Xin, Jing-yu Chen, Ling-ling Zhang, Yan Chang, Yu-jing Wu, Wei Wei
Summary: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovitis and small joint destruction. IgD stimulation may contribute to RA pathogenesis and IgD-Fc-Ig serves as a potential treatment by inhibiting T-cell activation and blocking the IgD-IgDR signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Allergy
Franziska J. Rosser, Yueh-Ying Han, Erick Forno, Leonard B. Bacharier, Wanda Phipatanakul, Theresa W. Guilbert, Michael D. Cabana, Kristie Ross, Joshua Blatter, Sandy Durrani, James Luther, Stephen R. Wisniewski, Juan C. Celedon
Summary: This study aimed to determine the effect of vitamin D supplementation on total IgE and specific IgE levels in children with asthma and low vitamin D levels. Despite more subjects achieving adequate vitamin D levels with supplementation, there was no significant impact on IgE levels. Participants were followed for an average of 316 days.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hui Zhao, Jiannan Gong, Lifang Li, Shuyin Zhi, Guang Yang, Pingping Li, Ruina Li, Jianqiang Li
Summary: This study demonstrates that vitamin E relieves chronic obstructive pulmonary disease (COPD) by negatively regulating the EGFR/MAPK pathway and inhibiting COX2-mediated translocation of phosphorylated STAT3 to the nucleus. Moreover, overexpression of COX2 reverses the protective effect of vitamin E in a rat model of COPD.
LABORATORY INVESTIGATION
(2022)
Article
Clinical Neurology
Vera Bril, Michael Benatar, Henning Andersen, John Vissing, Melissa Brock, Bernhard Greve, Peter Kiessling, Franz Woltering, Laura Griffin, Peter van den Bergh
Summary: This study investigated the clinical efficacy and safety of subcutaneous rozanolixizumab in patients with gMG. While the primary endpoint of change in QMG score was not statistically significant, overall data suggest that rozanolixizumab may provide clinical benefit in patients with gMG and was generally well tolerated. Phase 3 evaluation is ongoing.
Article
Medicine, General & Internal
Cesar Picado, Inaki Ortiz de Landazuri, Alexandru Vlagea, Irina Bobolea, Ebymar Arismendi, Rosanel Amaro, Jacobo Sellares, Joan Bartra, Raimon Sanmarti, Jose Hernandez-Rodriguez, Jose-Manuel Mascaro, Jordi Colmenero, Eva C. Vaquero, Mariona Pascal
Summary: This study highlights the clinical manifestations of Selective IgE deficiency (SIgED), which include various infectious diseases, autoimmune conditions, eczematous dermatitis, and malignancies. Patients with SIgED have an increased risk of developing malignancies, warranting further prospective studies to better characterize this condition and determine its inclusion in the list of antibody deficiencies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Kwei-Lan Liu, Tsung-Lin Tsai, Wen-Chien Tsai, Shih-Fen Tsai, Chih-Hung Lee, Shu-Li Wang
Summary: Prenatal exposure to heavy metals may increase the risk of atopic diseases in children. In atopic children, serum tIgE levels peaked at the age of 11, while they remained stable from the age of 8 in non-atopic children.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ajay P. Nayak, Elham Javed, Dominic R. Villalba, Yinna Wang, Henry P. Morelli, Sushrut D. Shah, Nicholas Kim, Rennolds S. Ostrom, Reynold A. Panettieri, Steven S. An, Dale D. Tang, Raymond B. Penn
Summary: Prostaglandin E2 has various physiological effects on multiple airway cells through its actions on different E-type prostanoid receptor subtypes. The EP2 and EP4 receptors, in particular, play a role in regulating the contraction and signaling of airway smooth muscle. However, the effectiveness of subtype-specific agonists in relaxing the muscle under different stimulation conditions varies, suggesting the involvement of compartmentalized signaling mechanisms.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Immunology
Jer-Hwa Chang, Hsiao-Chi Chuang, Chia-Kwung Fan, Tsung-Yun Hou, Yu -Cheng Chang, Yueh-Lun Lee
Summary: This study investigated the antiallergic effects of Norisoboldine (NOR), a compound found in Radix Linderae, on allergic asthma and mast cell activation. The results showed that NOR reduced serum OVA-specific immunoglobulin E (IgE) levels, airway hyperresponsiveness, and eosinophilia in bronchoalveolar lavage fluid (BALF), while increasing the number of CD4+Foxp3+ T cells in the spleen. NOR also reduced airway inflammation, histamine and cytokine levels, and mast cell degranulation. These findings suggest that NOR could be a potential therapeutic option for allergic asthma by regulating mast cell function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ming-Huang Chiu, Tsung-Yun Hou, Chia-Kwung Fan, Jer-Hwa Chang, Chu-Lun Lin, Shih-Chun Huang, Yueh-Lun Lee
Summary: Catalpol demonstrated significant anti-allergic effects by suppressing mast cell degranulation, reducing inflammatory mediator generation, and lowering levels of Th2 cytokines and airway inflammation in allergic asthma models.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Feng, Shengchong Chen, Luyang Xiong, Chenli Chang, Wenliang Wu, Dian Chen, Jiali Gao, Gongqi Chen, Lingling Yi, Guohua Zhen
Summary: CDH26 serves as a key regulator of epithelial IL-4R signaling in asthma, playing a role in airway hyperresponsiveness, mucus overproduction, and eosinophilia. It modulates IL-4R signaling by regulating IL-13 binding, IL-4R alpha expression, and downstream phosphorylation of Jak1 and Stat6. CDH26 may serve as a potential therapeutic target for IL-4R-mediated allergic diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Multidisciplinary Sciences
Samuel Weeks, Rebecca Harris, Mobin Karimi
Summary: This review explores the role of ITK signaling in multiple diseases, including T cell-derived malignancies, allergic diseases, infectious diseases, autoimmune disorders, and the potential use of ITK inhibition in transplantation recipients.