The Strictly Conserved Arg-321 Residue in the Active Site ofEscherichia coliTopoisomerase I Plays a Critical Role in DNA Rejoining

The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites

(2010) Gagandeep Narula et al.   BMC BIOCHEMISTRY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Use of Divalent Metal Ions in the DNA Cleavage Reaction of Human Type II Topoisomerases†

(2009) Joseph E. Deweese et al.   BIOCHEMISTRY

Effects of magnesium and related divalent metal ions in topoisomerase structure and function

(2009) C. Sissi et al.   NUCLEIC ACIDS RESEARCH

Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms

(2009) P. Forterre et al.   NUCLEIC ACIDS RESEARCH

Recent advances in bacterial topoisomerase inhibitors

(2008) B BRADBURY et al.   CURRENT OPINION IN PHARMACOLOGY

Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to E. coli

(2008) Bokun Cheng et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Mg 2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region

(2008) Elena P. Sorokin et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS