Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Medicine, General & Internal
Ichiro Wakabayashi, Harald Sourij, Yoko Sotoda, Takashi Daimon, Klaus Groschner, Peter P. Rainer
Summary: There were no significant differences in serum levels of ALDH2- and ADH1B-related miRNAs between Austrian and Japanese middle-aged men. However, miR-150-3p and miR-4314 showed higher expression levels in Austrian men compared to Japanese men, indicating they may play a role in the ethnic difference in sensitivity to alcohol through modifying the expression of ADH1B.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Brandt C. Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D. Buchman, Cyrus Takahashi, Bikash Debnath, Stacy C. McGonigal, Shuai Mao, Siwei Li, Jeremy Felton, Shu Pan, Bo Wen, Duxin Sun, Nouri Neamati, Ronald J. Buckanovich, Thomas D. Hurley, Scott D. Larsen
Summary: Research continues to develop pan-ALDH1A inhibitors to examine their effectiveness in combating chemotherapy-resistant ovarian cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ilias Tsochantaridis, Angelos Roupas, Georgia-Persephoni Voulgaridou, Alexandra Giatromanolaki, Michael I. Koukourakis, Mihalis I. Panayiotidis, Aglaia Pappa
Summary: Aldehyde dehydrogenase 1B1 (ALDH1B1) plays a significant pathophysiological role in human colorectal adenocarcinoma by altering cell morphology, decreasing proliferation rate, triggering G2/M arrest, enhancing drug resistance, increasing migratory potential, and inducing epithelial-mesenchymal transition (EMT).
Article
Chemistry, Multidisciplinary
Miae Won, Ji Hyeon Kim, Myung Sun Ji, Jong Seung Kim
Summary: ALDH, a cancer stem cell biomarker associated with drug resistance, can be targeted using a prodrug called DE-CPT, which efficiently decreases the population of CSCs and kills cancer cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa'a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Summary: This study found that histone deacetylase inhibitor valproic acid (VPA) can alter glucose metabolism in triple-negative breast cancer (TNBC) cells and is correlated with cisplatin sensitivity. Overexpression of ALDH may be one mechanism of cellular resistance to VPA, and its inhibition can enhance the therapeutic efficacy of VPA-chemotherapeutic drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jinhong Liu, Shey-Li Lim, Jia Yi Zhong, Boon Leong Lim
Summary: Developed ratiometric biosensors for pyridine nucleotides to study energy metabolism in pollen tubes and the role of pollen plastids. Found that fermentation and pyruvate dehydrogenase bypass are not essential for pollen tube growth in Arabidopsis.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A. Genazzani
Summary: Tumor cells modify their cellular metabolism in order to sustain uncontrolled proliferation, requiring adequate amounts of NAD and NADPH to support overexpressed enzymes. This review explores the rationale for targeting key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and enzymes that consume or use NADP(H).
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Zheng Peng, Ran Wang, Xiaofeng Xia, Juan Zhang
Summary: A visualized high-throughput method was developed to screen ALDH variants, and a variant ALDH(S273N) with the highest activity was identified. This variant showed efficient degradation of acetaldehyde, making it a promising green bio-elimination technology.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Medicine, General & Internal
Blanka Wolszczak-Biedrzycka, Elzbieta Zasimowicz-Majewska, Anna Bienkowska, Grzegorz Biedrzycki, Justyna Dorf, Wojciech Jelski
Summary: This study demonstrates the diagnostic usefulness of determining the total ADH, ADH I, and ADH II activity in the serum of patients with alcoholic fatty liver.
MEDICINA-LITHUANIA
(2022)
Article
Biochemistry & Molecular Biology
Roger S. Holmes
Summary: The study identified tetraploid copies of 10 Xenopus laevis ALDH genes, while another 7 ALDH genes were diploid in nature. The ALDH amino acid sequences of Xenopus laevis and Xenopus tropicalis were highly homologous with human enzymes, except for mitochondrial signal peptide sequences. Amino acids responsible for catalytic and structural roles were conserved and identified based on previous reports of 3D structures of corresponding mammalian enzymes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Martha B. Alvarez-Elizondo, Daphne Weihs
Summary: In this study, the invasiveness of CD44(+)ALDH(+) cancer stem-like cells (CSCs) was investigated using a rapid mechanobiology-based assay. It was found that CD44(+)ALDH(+) cells showed higher invasiveness and migratory capacity, suggesting their potential role in disease progression and as prognostic markers for recurrence and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michael E. Ayenero, Gbemi E. Akinwusi, Adejoke N. Kolawole, Babatunde A. Falese, Idowu J. Olawuni, Ayodele O. Kolawole
Summary: This study investigated the in vitro interactions of a potent antioxidant and anti-ulcerative isoflavonoid, homopterocarpin, with human serum albumin (HSA) and human aldehyde dehydrogenase (hALDH) using various spectroscopic methods, in silico and molecular dynamic (MD) studies. The results showed that homopterocarpin quenched the intrinsic fluorescences of HSA and hALDH and the interactions were mainly driven by hydrophobic interactions. The binding affinity of homopterocarpin to HSA was higher than to hALDH, and the complex between HSA and homopterocarpin exhibited faster reversible equilibration time compared to ALDH-homopterocarpin complex. The findings of this research have significant implications for understanding the pharmacokinetics characteristics of homopterocarpin at the clinical level.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Cell Biology
Maxim Olsson, Peter Larsson, Junko Johansson, Vasu R. Sah, Toshima Z. Parris
Summary: This study revealed the enrichment of potentially treatment-resistant cancer stem cell subpopulations in the M and BL2 triple-negative breast cancer subtypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Raquel Pequerul, Sergio Porte, Xavier Pares, Mileidys Perez-Alea, Jaume Farres
Summary: This standardized protocol presents a method for production and purification of ALDH isoform proteins, as well as optimized enzymatic activity assays. Its significance lies in bridging the gap and providing a tool for diagnostic and treatment purposes in cancer and other diseases.
Article
Ophthalmology
Julia Stingl, Sol A. Ban, Markus Nagler, Irene Schmidtmann, Philipp S. Wild, Karl J. Lackner, Thomas Muenzel, Manfred E. Beutel, Norbert Pfeiffer, Alexander K. Schuster
Summary: The study found that the refractive error in phakic eyes changes with age, with a myopic shift at the age of 35-44 and a hyperopic shift at the age of 45-64. This shift decreases with higher age. Smoking is associated with a hyperopic shift, while female sex and myopic baseline SE are associated with a myopic shift. Educational level and occupation were not linked to a change in refractive error at the age of 35-74.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychology, Clinical
Danieelle Otten, Mareike Ernst, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Elmar Braehler, Joerg Wiltink, Matthias Michal, Markus Nagler, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Peiffer, Manfred E. Beutel
Summary: This study aimed to predict the occurrence of chronic diseases based on baseline depressive symptoms and to examine the sex-dependent effects. The results showed that baseline depressive symptoms predicted cardiovascular disease, chronic obstructive lung disease, diabetes, and migraine in both men and women, but not cancer. Additional adjustments for metabolic and lifestyle risk factors increased the risk of chronic obstructive lung disease and migraine for each point of depressive symptoms. There were trends suggesting a relevance of depressive symptoms for cardiovascular disease in men and for diabetes in women.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Omar Hahad, Andreas Daiber, Philip J. Landrigan
Summary: Healthy soil is essential for human health as it supports the growth of crops, provides food, and sustains populations. However, soil pollution poses a great threat to human health, reducing soil's ability to yield food and resulting in contamination and disease. It also causes water pollution and contributes to air, water, and soil pollution, leading to millions of deaths each year.
CARDIOVASCULAR RESEARCH
(2023)
Article
Ophthalmology
Achim Fiess, Michael S. Urschitz, Markus Nagler, Stefan Nickels, Susanne Marx-Gross, Thomas Muenzel, Philipp S. Wild, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to analyze the long-term effect of low birth weight on corneal aberrations in adulthood. The results indicated that low birth weight is associated with increased spherical aberration, which may affect optical image quality and visual function.
JOURNAL OF OPTOMETRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Muenzel, Tommaso Gori
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Anna C. Mavromanoli, Stefano Barco, Walter Ageno, Helene Bouvaist, Marianne Brodmann, Claudio Cuccia, Francis Couturaud, Claudia Dellas, Konstantinos Dimopoulos, Daniel Duerschmied, Klaus Empen, Pompilio Faggiano, Emile Ferrari, Nazzareno Galie, Marcello Galvani, Alexandre Ghuysen, George Giannakoulas, Menno Huisman, David Jimenez, Matija Kozak, Irene M. Lang, Nicolas Meneveau, Thomas Muenzel, Massimiliano Palazzini, Antoniu Octavian Petris, Giancarlo Piovaccari, Aldo Salvi, Sebastian Schellong, Kai-Helge Schmidt, Franck Verschuren, Irene Schmidtmann, Gerrit Toenges, Frederikus A. Klok, Stavros Konstantinides
Summary: This study analyzed the changes in RV function in patients with intermediate-risk PE who were switched early to oral anticoagulation. The results showed that the majority of patients had normalized RV function within 6 days and maintained normal RV function throughout the first 6 months. However, almost one in four patients continued to have evidence of RV dysfunction over the long term.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Respiratory System
Karsten Keller, Volker H. Schmitt, Mir A. Ostad, Thomas Muenzel, Lukas Hobohm, Christine Espinola-Klein
Summary: Pulmonary embolism is a life-threatening acute disease. Risk stratification of hospitalized patients with PE is crucial. The performance of Mansoor's Self-Report Tool for Cardiovascular Risk Assessment in predicting adverse in-hospital events was evaluated.
CLINICAL RESPIRATORY JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
John F. Keaney, Thomas Muenzel
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Physiology
Andreas Daiber, Marin Kuntic, Matthias Oelze, Omar Hahad, Thomas Muenzel
Summary: Smoking is a major cardiovascular health risk factor, and the decline in tobacco cigarette use is partially offset by the rise in shisha smoking and e-cigarette vaping. E-cigarettes may have less harm than tobacco smoking but can still cause oxidative stress, inflammation, endothelial dysfunction, and cardiovascular problems. Both vaping and smoking have similar detrimental effects on endothelial function due to the overlapping toxic compounds in vapor and tobacco smoke. The belief that e-cigarettes help quit smoking and nicotine addiction may be false. This review emphasizes the adverse health effects of tobacco cigarettes and e-cigarettes, particularly on endothelial function and cardiovascular health.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Virology
Volker H. Schmitt, Lukas Hobohm, Ingo Sagoschen, Visvakanth Sivanathan, Omar Hahad, Christine Espinola-Klein, Thomas Muenzel, Karsten Keller
Summary: A study in Germany found that diabetes mellitus (DM) has a significant impact on the clinical outcome of patients with COVID-19 infection. Compared to non-diabetic patients, COVID-19 patients with DM are more likely to develop pneumonia, acute respiratory distress syndrome, require intensive care, and have a higher mortality rate.
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Goebel, Arthur Wingerter, Juergen H. Prochaska, Andreas Schulz, Marie A. Neu, Nicole Henninger, Claudia Spix, Manfred Beutel, Karl Lackner, Thomas Muenzel, Carolyn S. Lam, Hiltrud Merzenich, Joerg Faber, Philipp S. Wild
Summary: The CVSS study found that the prevalence of different stages of heart failure in childhood cancer survivors is higher than the general population, but varies significantly based on tumor history. Systolic dysfunction is primarily associated with tumor entities, while diastolic dysfunction is associated with a higher burden of cardiovascular risk factors in childhood cancer survivors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Berit Hackenberg, Karoline O'Brien, Julia Doege, Karl J. J. Lackner, Manfred E. E. Beutel, Thomas Muenzel, Norbert Pfeiffer, Andreas Schulz, Irene Schmidtmann, Philipp S. S. Wild, Christoph Matthias, Katharina Bahr-Hamm
Summary: This study aimed to assess the prevalence of tinnitus in a large German cohort and determine its relationship with hearing impairment. The results showed that tinnitus is common in the German population, and its prevalence increases with age. Severe hearing loss was found to be associated with the occurrence of tinnitus.
MEDICINA-LITHUANIA
(2023)
Article
Infectious Diseases
Ornela Velollari, Christian Malte Reinhardt, Maike Knorr, Katharina Schnitzler, Dirk Graafen, Matthias Miederer, Ralph Stephan von Bardeleben, Thomas Muenzel, Kai-Helge Schmidt, Christian Giebels, Hans-Joachim Schaefers, Lukas Hobohm
Summary: This case study presents a patient with prosthesis endocarditis and paraaortic abscess caused by Cutibacterium acnes. The use of diagnostic imaging techniques confirmed the inflammatory process. The patient was treated with intravenous antibiotics and surgical intervention.
INFECTIOUS DISEASE REPORTS
(2023)