Pro-nerve Growth Factor Induces Autocrine Stimulation of Breast Cancer Cell Invasion through Tropomyosin-related Kinase A (TrkA) and Sortilin Protein

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival

(2011) E. Vanhecke et al.   CLINICAL CANCER RESEARCH

Breast Cancer-Induced Bone Remodeling, Skeletal Pain, and Sprouting of Sensory Nerve Fibers

(2011) Aaron P. Bloom et al.   JOURNAL OF PAIN

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

Overexpression of p75NTR increases survival of breast cancer cells through p21waf1

(2010) Stéphanie Verbeke et al.   CELLULAR SIGNALLING

Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways

(2010) Rodrigue Romon et al.   Molecular Cancer

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors

(2009) Raheleh Masoudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin

(2009) Dan Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain

(2009) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

(2009) X Montano   ONCOGENE

TrkA overexpression enhances growth and metastasis of breast cancer cells

(2009) C Lagadec et al.   ONCOGENE

Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation

(2009) C. Matrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

(2008) E. Adriaenssens et al.   CANCER RESEARCH

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

(2008) Jacqueline Boutilier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotrophins and Their Receptors Stimulate Melanoma Cell Proliferation and Migration

(2008) Francesca Truzzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY