Review
Chemistry, Multidisciplinary
Yeqing Xia, Weifeng Zhang, Shuai Yang, Liping Wang, Gui Yu
Summary: Covalent organic frameworks (COFs) are new organic porous materials with pre-designable topology, adjustable pore size, and abundant active sites. Donor-acceptor (D-A) type COFs, synthesized by introducing D and A units into the COFs backbone, combine the advantages of D-A type polymers with the unique features of COFs. This review outlines the synthetic strategies of D-A type COFs, summarizes their applications in catalytic reactions, photothermal therapy, and electronic materials, and presents the current challenges and new directions for their development.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Organic
Prahallad Meher, Satya Prakash Panda, Sanat Kumar Mahapatra, Karan Ramdas Thombare, Lisa Roy, Sandip Murarka
Summary: We report a photoredox system that can form a self-assembled complex and activate diaryliodonium reagents for arylation of heterocycles under mild conditions.
Article
Chemistry, Multidisciplinary
Yang Jiao, Luka Dordevic, Haochuan Mao, Ryan M. Young, Tyler Jaynes, Hongliang Chen, Yunyan Qiu, Kang Cai, Long Zhang, Xiao-Yang Chen, Yuanning Feng, Michael R. Wasielewski, Samuel Stupp, J. Fraser Stoddart
Summary: This study enhances the charge-transfer interactions between donor and acceptor molecules through mechanical interlocking, leading to increased absorption of visible light and good catalytic activity. The [2]catenane demonstrated excellent performance in both photo-reductions and -oxidations, showing potential for solar energy conversion and development of active artificial molecular shuttles, switches, and machines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Haye Min Ko, Chung Whan Lee, Min Sang Kwon
Summary: Visible-light photocatalysis has become a powerful tool for organic transformations recently. Concerns over the toxicity and sustainability of transition metal-based complexes have led to the exploration of organic photocatalysts. Donor-acceptor cyanoarenes, originally developed as thermally activated delayed fluorescence emitters, have gained attention as efficient photocatalysts. This review provides an overview of recent studies on the stability of organic photocatalysts, discussing key issues such as photodegradation and interactions with active species.
Article
Chemistry, Multidisciplinary
Emma G. L. Robert, Vincent Pirenne, Matthew D. Wodrich, Jerome Waser
Summary: A convenient method for the one-step synthesis of beta-aminocyclobutane monoesters using commercially available reagents is reported. The obtained strained rings undergo dearomative annulation with indole partners using silylium catalysis, providing tricyclic indolines with four new stereocenters. The reaction can proceed both intra- and intermolecularly and the outcome can be selectively controlled based on reaction temperature, resulting in the formation of either akuamma or malagasy alkaloid-like tetracyclic structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xin Liang, Yufei Li, Qing Xia, Lan Cheng, Jianbo Guo, Pei Zhang, Weihua Zhang, Qingmin Wang
Summary: This work presents an efficient sulfonylation reaction using a visible-light-induced radical coupling reaction between phenyl/heterocyclic diazonium salts and sulfinates. Mechanistic experiments revealed the formation of a versatile electron donor-acceptor (EDA) complex. This transformation is characterized by its easy operational procedure under mild conditions and the absence of transition metals, ligands, catalysts, and oxidants.
Article
Chemistry, Organic
Chang Xu, Fang-Qi Shen, Gaofeng Feng, Jian Jin
Summary: A novel visible-light-induced alpha-amino C-H bond arylation protocol has been discovered, enabled by electron donor-acceptor complexes. This method does not require a photoredox catalyst, transition metal, oxidant, or exclusion of oxygen or moisture. High yields of arylated amines were obtained by directly irradiating a mixture of tertiary amines and benzonitriles with visible light in the presence of Cs2CO3 in N,N-diethylethanamide.
Article
Chemistry, Multidisciplinary
Yuan-Zhao Peng, Guang-Chen Guo, Song Guo, Li-Hui Kong, Tong-Bu Lu, Zhi-Ming Zhang
Summary: Decorating conjugated microporous polymers with polycyclic aromatic hydrocarbons has improved photosensitization and facilitated efficient photosynthesis by promoting intersystem crossing and electron-hole separation. The structure-property-activity relationship of these polymers demonstrates a new approach for developing heavy-atom-free heterogeneous photosensitizers with highly efficient sensitizing activity at a molecular level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Fengxuan Zhang, Fanxing Zhou, Shiheng Yin, Bei Long, Guo-Jun Deng, Atif Ali, Ting Song
Summary: In this study, donor-acceptor conjugated polymers with different inert groups were designed and synthesized to optimize the migration ability of photogenerated carriers and the adsorption of reactant sequences. The results showed that the introduction of methyl groups preserved the D-A structure in the conjugated polymer, enabling selective reduction of CO2 to CH4 and oxidation of thioether to sulfoxide under visible light irradiation. This study emphasizes the importance of adding inert groups to create multifunctional photocatalysts.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Chemistry, Multidisciplinary
Joanna Turkowska, Jakub Durka, Michal Ociepa, Dorota Gryko
Summary: In this study, it was found that vitamin B-12 catalysis can transform an initially electrophilic center into a nucleophilic radical, enabling reactions with SOMOphiles. This radical-based strategy reverses the standard regioselectivity and complements classical approaches.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Liangliang Yang, Jieyin He, Haiyang Wang, Wendi Xu, Xue Zhang, Ming Lang, Jian Wang, Shiyong Peng
Summary: In this study, a copper-catalyzed (5 + 3) annulation of donor-acceptor cyclopropanes with imidazolidines was reported, providing a straightforward method to access a library of saturated 1,4-diazocanes. The asymmetric synthesis of optically active saturated 1,4-diazocanes was also achieved by two strategies: chirality transfer and dynamic kinetic asymmetric transformation.
Article
Polymer Science
Maoji Zhao, Shuaishuai Zhu, Xue Yang, Yong Wang, Xingping Zhou, Xiaolin Xie
Summary: A heterogeneous catalyst with a unique structure synthesized by the Debus-Radziszewski reaction shows improved catalytic activity compared to small molecular analogs in polymerization reactions, producing polymers with narrow distribution and high chain-end fidelity. The catalyst can be easily separated and recycled multiple times.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jingjun Li, Shui-Ying Gao, Jiaying Liu, Shihua Ye, Yanan Feng, Duan-Hui Si, Rong Cao
Summary: A method for stabilizing donor-acceptor covalent organic frameworks (D-A COFs) through intramolecular hydrogen bonds and membrane-based mass transfer strategy is reported. The COF design focuses on the crystalline stability and charge transfer optimization, leading to well-defined and stable structure along with controlled reactive oxygen species yields. Integration of COFs with polyvinylidene fluoride membrane enables robust activity and stability in photocatalysis, with high turnover frequency value. This study provides a facile approach for stabilizing D-A COFs and explores a general membrane-based mass transfer strategy for photocatalysis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ryo Miyajima, Yuuki Ooe, Tomoaki Miura, Tadaaki Ikoma, Hajime Iwamoto, Shin-ya Takizawa, Eietsu Hasegawa
Summary: Triarylamine-substituted benzimidazoliums (BI+- PhNAr2), new electron donor-acceptor dyad molecules, were synthesized and their photocatalytic properties for reductive organic transformations were explored. The results show that irradiation of BI+-PhNAr2 promotes photoinduced intramolecular electron transfer, forming a long-lived charge shifted state. Among the benzimidazoliums explored, the bromo-substituted analogue BI+-PhN(C6H4Br-p)2 in conjunction with BIH-Ph demonstrates the most consistent catalytic performance.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Fang-Yuan Nie, Yi-Ping Cai, Qin-Hua Song
Summary: In this paper, a photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes is developed. The reactions are initiated by photoinduced single electron transfer and successfully convert pyridinaldehydes and 2-quinolinaldehydes to the corresponding ketones. Besides, this method also enables two other transformations.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Masato Yoshimura, Nai-Chi Chen, Hong-Hsiang Guan, Phimonphan Chuankhayan, Chien-Chih Lin, Atsushi Nakagawa, Chun-Jung Chen
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Elahe K. Astani, Nai-Chi Chen, Yen-Chieh Huang, Sara Ersali, Pei-Ju Lin, Hong-Hsiang Guan, Chien-Chih Lin, Phimonphan Chuankhayan, Chun Jung Chen
Article
Biochemical Research Methods
Chomphunuch Songsiriritthigul, Rawint Narawongsanont, Chonticha Tantitadapitak, Hong-Hsiang Guan, Chun-Jung Chen
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Elahe K. Astani, Sara Ersali, Yao-Chang Lee, Pei-Ju Lin, Yen-Chieh Huang, Pei-Yu Huang, Vahab Jafarian, Saman Hosseinkhani, Chun-Jung Chen
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2020)
Article
Biochemical Research Methods
Chomphunuch Songsiriritthigul, Natsajee Nualkaew, James Ketudat-Cairns, Chun Jung Chen
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Sunney I. Chan, Phimonphan Chuankhayan, Pavan Kumar Reddy Nareddy, I-Kuen Tsai, Yi-Fang Tsai, Kelvin H. -C. Chen, Steve S. -F. Yu, Chun-Jung Chen
Summary: The active site of methanol dehydrogenase contains a rare disulfide bridge that may work together with the PQQ prosthetic group and Ca2+ ion during catalysis. Studies show that the disulfide bridge undergoes redox reactions within the protein, producing a disulfide radical anion and a companion PQQ radical. These findings suggest a mechanism for controlled electron redistribution during alcohol oxidation, avoiding the formation of reduced PQQ ethenediol and allowing for possible recovery of the hydride for multiple catalytic turnovers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang
Summary: This study reported the crystal structures of Saccharomyces cerevisiae DHOase in complex with malate, 5-fluorouracil, and 5-aminouracil. The findings revealed the binding characteristics of 5-FU and 5-AU to DHOase, providing structural insights for the development of new inhibitors targeting DHOase.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang
Summary: The study identified PLU from plant extracts as a competitive inhibitor of DHOase, showing potential anti-cancer properties by affecting pyrimidine nucleotide biosynthesis and cancer cell survival. Structural insights provided by this research may aid in developing new inhibitors targeting DHOase for future clinical anticancer chemotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang
Summary: DHOase is a protein with a metal center that catalyzes the cyclization of N-carbamoyl aspartate to dihydroorotate, playing a critical role in the biosynthesis of pyrimidine nucleotides. The structural flexibility allows DHOase to bind different ligands and exhibit diverse functions.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tsung-Wei Shih, Chen-Lien Hsu, Li-Ying Chen, Yen-Chieh Huang, Chun-Jung Chen, Yoshihisa Inoue, Teruki Sugiyama
Summary: A new polymorph of beta-cyclodextrin was successfully produced in D2O solution using laser-induced crystallization method, resulting in single prism crystal and multiple plate crystals with different morphology and Raman spectrum. The plate crystal showed lower solubility in D2O, indicating higher thermodynamic stability compared to the prism crystal. The generation probability of these two polymorphs was found to be influenced by factors such as initial beta-CD concentration, laser power, and laser polarization mode.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang
Summary: This study investigated the crystal structures of the eukaryotic Saccharomyces cerevisiae DHOase complexed with malate. Through comparison with different DHOases, it was found that ScDHOase can form tetramers, with subunit-interacting residues for dimerization and tetramerization differing significantly from other DHOases.
Article
Biochemistry & Molecular Biology
Yu-Yung Chang, Meng-Hsuan Hsieh, Yen-Chieh Huang, Chun-Jung Chen, Ming-Tao Lee
Summary: In this study, the structural characteristics and thermal stability of α-crystallin proteins were investigated using CD and SAXS techniques. The results showed that α-crystallin proteins exhibited transition behavior in conformation with increasing temperature, and alpha A and alpha B crystallin had different properties in thermal stability. These findings provide important insights into the chaperone-like activity of α-crystallin proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kuang-Lung Hsueh, Liang-Kun Yu, Yin-Cheng Hsieh, Ya-Yun Hsiao, Chun-Jung Chen
Summary: Bacteria rely on the Feo system for the uptake of ferrous iron, and the presence of the FeoC cofactor [4Fe-4S] has been found to enhance the GTPase activity of FeoB. In this study, the researchers monitored the GTPase activity of FeoB in the presence of FeoC-[4Fe4S]3+, and found that it increased the GTPase rate of NFeoB. Furthermore, they identified specific amino acids on FeoC and NFeoB that contribute to the GTPase activity. The researchers propose that bacteria may use the oxygen-sensitive cluster as a sensor to regulate the closing speed of the gate.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2023)
Article
Multidisciplinary Sciences
Nai-Chi Chen, Chun-Hsiung Wang, Masato Yoshimura, Yi-Qi Yeh, Hong-Hsiang Guan, Phimonphan Chuankhayan, Chien-Chih Lin, Pei-Ju Lin, Yen-Chieh Huang, Soichi Wakatsuki, Meng-Chiao Ho, Chun-Jung Chen
Summary: Understanding the structural diversity of honeybee-infecting viruses is crucial for protecting pollinator health and managing disease spread in ecology and agriculture. This study used cryo-EM to determine the structures of T=4 and T=3 capsids of Lake Sinai virus (LSV) 2 and delta-N48 LSV1. The analysis revealed unique structural features and interactions of the capsid proteins, as well as the impact of pH on capsid conformations and particle sizes.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sruthi Thiraviam Saravanan, Saritha Poopandi, Yen-Chieh Huang, Amala Mathimaran, Jeyakanthan Jeyaraman, Chun-Jung Chen
Summary: Lymphatic filariasis is a debilitating disease caused by the Brugia malayi parasite in the human lymphatic system. Current drugs are only effective against the larvae and there is a need for a new drug to prevent adult worm survival. This study focuses on the essential DapE gene in the Wolbachia endosymbiont of Brugia malayi, and its deletion has been found to be lethal to the organism.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)