Engineering Thrombin for Selective Specificity toward Protein C and PAR1

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

(2010) Wolfram Bode et al.   PROTEIN SCIENCE

Structural basis of substrate specificity in the serine proteases

(2010) John J. Perona et al.   PROTEIN SCIENCE

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Mutant N143P Reveals How Na+Activates Thrombin

(2009) Weiling Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of theE* Form Turns Thrombin into an Anticoagulant

(2009) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

(2009) Prafull S. Gandhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the A chain in thrombin function

(2008) M. E. Papaconstantinou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Serine peptidases: Classification, structure and function

(2008) M. J. Page et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thrombin

(2008) Enrico Di Cera   MOLECULAR ASPECTS OF MEDICINE

The search for new cardiovascular biomarkers

(2008) Robert E. Gerszten et al.   NATURE

Engineering protease specificity made simple, but not simpler

(2008) Enrico Di Cera   Nature Chemical Biology

Highly active and selective endopeptidases with programmed substrate specificities

(2008) Navin Varadarajan et al.   Nature Chemical Biology

Structural identification of the pathway of long-range communication in an allosteric enzyme

(2008) P. S. Gandhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA