Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

(2009) Hosea Handoyo et al.   BIOCHEMICAL JOURNAL

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production

(2009) Kevin Cusack et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Myeloperoxidase Deficiency Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation and Subsequent Cytokine and Chemokine Production

(2009) A. Haegens et al.   JOURNAL OF IMMUNOLOGY

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1  Production

(2009) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

Bioluminescence imaging of myeloperoxidase activity in vivo

(2009) Shimon Gross et al.   NATURE MEDICINE

Targeting innate immunity protein kinase signalling in inflammation

(2009) Matthias Gaestel et al.   NATURE REVIEWS DRUG DISCOVERY

The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain

(2009) E. Giannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

(2008) Dawn George et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration

(2008) Cristina Rodríguez et al.   CELLULAR SIGNALLING

Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation

(2008) Driss El Kebir et al.   CIRCULATION RESEARCH

In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene

(2008) Yan-Li Li et al.   FEBS Journal

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice

(2008) Waldiceu A. Verri Jr et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IL–1β-stimulated activation of ERK1/2 and p38α MAPK mediates the transcriptional up-regulation of IL–6, IL–8 and GRO-α in HeLa cells

(2007) Huei-Ting Yang et al.   CELLULAR SIGNALLING