4.7 Article

K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 12, Pages 7878-7881

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01251-15

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Funding

  1. French Institute for Public Health Surveillance (InVS)

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Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L, N554H/K, and E596G). A total of 23.8% of the isolates from the Union of Comoros showed K13-propeller polymorphisms. Three of the 18 isolates (16.7%) from Grande Comore showed polymorphisms (N490H, N554K, and E596G).

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