Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography

P450cam Visits an Open Conformation in the Absence of Substrate,

(2010) Young-Tae Lee et al.   BIOCHEMISTRY

Two-dimensional NMR and All-atom Molecular Dynamics of Cytochrome P450 CYP119 Reveal Hidden Conformational Substates

(2010) Jed N. Lampe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction

(2010) Namandjé N. Bumpus et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-A Resolution

(2010) S. C. Gay et al.   MOLECULAR PHARMACOLOGY

Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency

(2010) O. A. Oyeyemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

H/D Exchange and Mass Spectrometry in the Studies of Protein Conformation and Dynamics: Is There a Need for a Top-Down Approach?

(2009) Igor A. Kaltashov et al.   ANALYTICAL CHEMISTRY

Steroid and Protein Ligand Binding to Cytochrome P450 46A1 as Assessed by Hydrogen−Deuterium Exchange and Mass Spectrometry

(2009) Wei-Li Liao et al.   BIOCHEMISTRY

Redox-Dependent Dynamics in Cytochrome P450cam

(2009) Susan Sondej Pochapsky et al.   BIOCHEMISTRY

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through α-Helical Repositioning,

(2009) Sean C. Gay et al.   BIOCHEMISTRY

Protein Folding and Protein-Ligand Interactions Monitored by Electrospray Mass Spectrometry

(2009) Peter Ferguson et al.   Current Analytical Chemistry

Investigating the Structural Plasticity of a Cytochrome P450

(2009) Carmelinda Savino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Ion-induced Domain Organization in Metallo-β-lactamases

(2009) Nathalie Selevsek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding

(2009) A. Bakan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native state dynamics drive the unfolding of the SH3 domain of PI3 kinase at high denaturant concentration

(2009) A. H. Wani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection

(2008) S. Michael Soltis et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Substrate binding to cytochromes P450

(2008) Emre M. Isin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structural Changes of eIF4E upon Binding to the mRNA 5′ Monomethylguanosine and Trimethylguanosine Cap†

(2008) Izabela Rutkowska-Wlodarczyk et al.   BIOCHEMISTRY

Interaction Between Cytochrome c and the Hapten 2,4-Dinitro-fluorobenzene by Electrospray Ionization Mass Spectrometry

(2008) Bo Wu et al.   CHINESE JOURNAL OF CHEMICAL PHYSICS

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

(2008) Dmitri R Davydov et al.   Expert Opinion on Drug Metabolism & Toxicology

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

(2008) Lars Konermann et al.   JOURNAL OF MASS SPECTROMETRY

Thermodynamic Fidelity of the Mammalian Cytochrome P450 2B4 Active Site in Binding Substrates and Inhibitors

(2008) B.K. Muralidhara et al.   JOURNAL OF MOLECULAR BIOLOGY

Hydrogen–deuterium exchange mass spectrometry for investigation of backbone dynamics of oxidized and reduced cytochrome P450cam

(2007) Yoshitomo Hamuro et al.   JOURNAL OF INORGANIC BIOCHEMISTRY