Review
Biotechnology & Applied Microbiology
Jancy Johnson, Yu-Wen Wu, Chantelle Blyth, Gregor Lichtfuss, Hadi Goubran, Thierry Burnouf
Summary: Platelet-derived EVs hold unique potential as therapeutic modalities due to their established clinical value, regulated collection procedures, and unique composition and tissue-targeting capacity. Researchers are interested in their translational potential for hemostasis, regenerative medicine, and drug delivery.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Cell Biology
Mauro Vismara, Marcello Manfredi, Marta Zara, Silvia Maria Grazia Trivigno, Luca Galgano, Silvia Stella Barbieri, Ilaria Canobbio, Mauro Torti, Gianni Francesco Guidetti
Summary: During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes. We have recently demonstrated that the activation of platelets by breast cancer cells is accompanied by a massive release of PEVs, evidence that matches with the observation that breast cancer patients display increased levels of circulating PEVs. Our study compared the PEVs released by platelets upon activation with thrombin and exposure to breast cancer cells, and found that the two populations of PEVs have different protein compositions and elicit different biological responses in target cells.
CELL DEATH DISCOVERY
(2022)
Article
Biochemical Research Methods
Junyoung Kim, Vijaya Sunkara, Jungmin Kim, Jooyoung Ro, Chi-Ju Kim, Elizabeth Maria Clarissa, Sung Wook Jung, Hee Jin Lee, Yoon-Kyoung Cho
Summary: Tumor-educated platelets play a critical role in tumorigenesis, cancer development, and metastasis. Researchers found that interleukin-8 (IL-8) in cancer-derived extracellular vesicles (EVs) contributed to platelet activation, resulting in increased platelet adhesion and potentially leading to tumor metastasis. Platelet adhesion levels can differentiate breast cancer patients with and without metastasis.
Article
Microbiology
James A. Cotton, Sasisekhar Bennuru, Alexandra Grote, Bhavana Harsha, Alan Tracey, Robin Beech, Stephen R. Doyle, Matthew Dunn, Julie C. Dunning Hotopp, Nancy Holroyd, Taisei Kikuchi, Olivia Lambert, Amruta Mhashilkar, Prudence Mutowo, Nirvana Nursimulu, Jose M. C. Ribeiro, Matthew B. Rogers, Eleanor Stanley, Lakshmipuram S. Swapna, Isheng J. Tsai, Thomas R. Unnasch, Denis Voronin, John Parkinson, Thomas B. Nutman, Elodie Ghedin, Matthew Berriman, Sara Lustigman
NATURE MICROBIOLOGY
(2017)
Article
Infectious Diseases
Jose Henrique M. Oliveira, Octavio A. C. Talyuli, Renata L. S. Goncalves, Gabriela Oliveira Paiva-Silva, Marcos Henrique F. Sorgine, Patricia Hessab Alvarenga, Pedro L. Oliveira
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Immunology
Clarissa R. Nascimento, Daniele Andrade, Carla Eponina Carvalho-Pinto, Rafaela Rangel Serra, Lucas Vellasco, Guilherme Brasil, Erivan Schnaider Ramos-Junior, Julia Barbalho da Mota, Larissa Nogueira Almeida, Marcus V. Andrade, Maria de Nazare Correia Soeiro, Luiz Juliano, Patricia Hessab Alvarenga, Ana Carolina Oliveira, Fernando Lencastre Sicuro, Antonio C. Campos de Carvalho, Erik Svensjo, Julio Scharfstein
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Infectious Diseases
Jessica C. Nevoa, Maria T. Mendes, Marcos V. da Silva, Siomar C. Soares, Carlo J. F. Oliveira, Jose A. M. C. Ribeiro
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Infectious Diseases
Jan Perner, Sara Kropackova, Petr Kopacek, Jose M. C. Ribeiro
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Microbiology
Il Hwan Kim, Julio Cesar Castillo, Azadeh Aryan, Ines Martin-Martin, Marcela Nouzova, Fernando G. Noriega, Ana Beatriz F. Barletta, Eric Calvo, Zachary N. Adelman, Jose M. C. Ribeiro, John F. Andersen
Editorial Material
Parasitology
Anderson Sa-Nunes, Carlo J. F. Oliveira, Jose M. Ribeiro
TRENDS IN PARASITOLOGY
(2020)
Article
Multidisciplinary Sciences
Lucas Tirloni, Gloria Braz, Rodrigo Dutra Nunes, Ana Caroline Paiva Gandara, Larissa Rezende Vieira, Teresa Cristina Assumpcao, Gabriela Alves Sabadin, Renato Martins Silva, Melina Garcia Guizzo, Josias Alves Machado, Evenilton Pessoa Costa, Daniele Santos, Helga Fernandes Gomes, Jorge Moraes, Maria Beatriz dos Santos Mota, Rafael Dias Mesquita, Milane de Souza Leite, Patricia Hessab Alvarenga, Flavio Alves Lara, Adriana Seixas, Rodrigo Nunes Fonseca, Andrea C. Fogaca, Carlos Logullo, Aparecida Sadae Tanaka, Sirlei Daffre, Pedro L. Oliveira, Itabajara Silva Vaz Jr, Jose M. C. Ribeiro
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Thiago Luiz Alves e Silva, Andrea Radtke, Amanda Balaban, Tales Vicari Pascini, Zarna Rajeshkumar Pala, Alison Roth, Patricia H. Alvarenga, Yeong Je Jeong, Janet Olivas, Anil K. Ghosh, Hanhvy Bui, Brandon S. Pybus, Photini Sinnis, Marcelo Jacobs-Lorena, Joel Vega-Rodriguez
Summary: The study demonstrates that Plasmodium gametes recruit human plasminogen to their surface and process it into plasmin, facilitating parasite migration in the host. Inhibition of plasminogen activation affects parasite development and is inversely correlated with mosquito infectivity.
Review
Multidisciplinary Sciences
Carolina Barillas-Mury, Jose M. C. Ribeiro, Jesus G. Valenzuela
Summary: This article reviews recent progress in the understanding of pathogen transmission from human to vector and from vector to host, and highlights new strategies for controlling vector-borne diseases.
Article
Infectious Diseases
Jose M. C. Ribeiro, Natalia J. Bayona-Vasquez, Khemraj Budachetri, Deepak Kumar, Julia Catherine Frederick, Faizan Tahir, Brant C. Faircloth, Travis C. Glenn, Shahid Karim
Summary: The Gulf Coast tick, Amblyomma maculatum, is a tick species found in the Southeastern states of the USA, extending from the Gulf of Mexico to Mexico and other Central and South American countries. This tick is a vector for Rickettsia parkeri and Hepatozoon americanum. A draft genome of A. maculatum was generated, revealing 237,921 protein-coding genes and providing insights into its basic biology.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Infectious Diseases
Melina Garcia Guizzo, Ben Mans, Ronel Pienaar, Jose M. C. Ribeiro
Summary: Tick saliva plays a role in blood feeding through its antihemostatic and immunomodulatory activities. Transcriptome analysis of tick salivary glands revealed a large number of transcripts coding for secreted polypeptides. However, many of these transcripts do not match the predicted proteomes, suggesting a high degree of polymorphism within the genes encoding these proteins.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Olivia Kern, Paola Carolina Valenzuela Leon, Apostolos G. Gittis, Brian Bonilla, Phillip Cruz, Andrezza Campos Chagas, Sundar Ganesan, Jose M. C. Ribeiro, David N. Garboczi, Ines Martin-Martin, Eric Calvo
Summary: Female mosquitoes require blood meals for egg development, and the saliva of blood feeding arthropods contains biochemically active molecules that aid in blood feeding. Culex quinquefasciatus, an important vector of parasitic and viral infections, has a 12-member family of putatively secreted proteins named the Cysteine and Tryptophan-Rich (CWRC) proteins. Two members of this family, CqDVP-2 and CqDVP-4, have been characterized, with evidence of interaction with carbohydrates important to host immunology and potential roles in pathogen transmission.
CURRENT RESEARCH IN STRUCTURAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ethan C. Strayer, Stephen Lu, Jose Ribeiro, John F. Andersen
Summary: The saliva from Anopheles mosquitoes inhibits the alternative pathway of complement, facilitating feeding by blocking the production of anaphylatoxins. Two proteins, albicin and SG7.AF, stabilize the C3bBb complex with different affinities for properdin. The SG7 family's functional role may differ in various mosquito species, as seen with albicin, SG7.AF, and Anophensin.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Willy Jablonka, Il Hwan Kim, Patricia H. Alvarenga, Jesus G. Valenzuela, Jose M. C. Ribeiro, John F. Andersen
SCIENTIFIC REPORTS
(2019)