Review
Endocrinology & Metabolism
Farzad Asadi, Savita Dhanvantari
Summary: This study focuses on the hyperglucagonemia in diabetic patients and the potential mechanisms of alpha cell dysfunction in pancreatic alpha cells, exploring how inhibition of glucagon secretion can be targeted for the treatment of diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Charlotte M. M. Gommers, Maria Aguila Ruiz-Sola, Alba Ayats, Lara Pereira, Marta Pujol, Elena Monte
Summary: In this study, it was found that Arabidopsis seedlings treated with lincomycin exhibited phenotypic similarities to those treated with the ethylene (ET) precursor, with the lincomycin-induced phenotype partially dependent on the ET signaling pathway. Both treatments showed overlap in upregulated gene transcripts, indicating how two apparently different stress responses converge to optimize photomorphogenesis.
Article
Biotechnology & Applied Microbiology
Yuhua Gao, Ningning Mi, Ying Zhang, Xiangchen Li, Weijun Guan, Chunyu Bai
Summary: Our study reveals that circRNA plays a role in regulating the activation of M1 macrophages and secretion of matrix metalloproteinases through the modulation of miR-1931 and NF-κB pathway. In the PROM model, EVs loaded with siRNAs targeting circRNAs can accelerate PROM occurrence.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ge Cheng, Zifang Zhang, Yixuan Wang, Youjiao Zao, Ruoqi Wang, Mengying Gao, Miaomiao Feng, Xi Zhang, Peng Jiang
Summary: Trichinella spiralis infection activates the TGF-beta 1/Smad3 pathway, promoting collagen secretion in muscle cells and playing an important role in the formation of collagen capsules. Further investigation is needed to identify the specific components in the Trichinella spiralis ES products that induce collagen synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Guanyi Chen, Bingyan Sun, Jiantao Li, Fawei Lin, Li Xiang, Beibei Yan
Summary: The study investigated the effect of promoting heat and mass transfer on the resource recovery of waste tires during pyrolysis. By designing a multifunctional fixed bed pyrolizer, it was possible to improve the quality of pyrolytic oil and reduce the emission of harmful pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Immunology
Ran Wei, Xin Li, Xiaocen Wang, Nan Zhang, Yuru Wang, Xichen Zhang, Pengtao Gong, Jianhua Li
Summary: Extracellular vesicles (EVs) secreted by Trypanosoma evansi (T. evansi) activate the TLR2-AKT signaling pathway to inhibit the production of inflammatory cytokines, thereby escaping the host's immune response. Kinetoplastid membrane protein-11 (KMP-11) in EVs is related to the promotion of T.evansi infection via AKT pathway.
Article
Medicine, General & Internal
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai -Min Bao
Summary: Increased expression of OXT in PVN and OXTR in DLPFC are characteristic for male BD patients. Stimulation of PVN-OXT neurons induced mood changes in mice, in a pattern different from BD.
Article
Geriatrics & Gerontology
Dorota Walkiewicz, Zofia Wicik, Monika Puzianowska-Kuznicka
Summary: The study identified pathways associated with age-related changes in human B lymphocytes, including the gonadotropin-releasing hormone receptor (GnRHR) pathway, which is involved in both aging and lymphocyte activation. Inhibition of the GnRHR pathway reduced cell proliferation, increased apoptosis, and led to decreased immunoglobulin G synthesis in B lymphocytes, with a more pronounced effect in centenarian cells compared to young cells.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu Wei, Zheng Wang, Yaqi Liu, Binyou Liao, Yawen Zong, Yangyang Shi, Min Liao, Jiannan Wang, Xuedong Zhou, Lei Cheng, Biao Ren
Summary: Extracellular vesicles (EVs) secreted by Candida albicans play important roles in promoting its own growth and enhancing its pathogenicity through activating the l-arginine/nitric oxide pathway.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Nathalie Josso, Jean-Yves Picard
Summary: Anti-Mullerian hormone (AMH) is a member of the TGF-beta family and is primarily produced by the supporting somatic cells of the testis. It plays a role in inhibiting the development of female internal organs and has other effects on germ cells. The signaling pathway of AMH is similar and different from other members of the TGF-beta family, and it has its own ligand-specific type 2 receptor, AMHR2, which distinguishes it from other family members. The relationship between AMH and AMHR2 is significant in the study of Persistent Mullerian Duct Syndrome.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Otorhinolaryngology
Marcos Custodio, Bruno Tavares Sedassari, Albina Altemani, Maria Fernanda Setubal Destro Rodrigues, Fabio Daumas Nunes, Suzana Cantanhede Orsini Machado de Sousa
Summary: Secretory carcinoma of salivary gland origin (SCsg) exhibits distinct expression patterns for mTOR signaling molecules, with only eIF4E showing high expression. This suggests the existence of alternative signaling pathways beyond Akt and mTOR in this type of tumors.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Immunology
Shuo Wan, Xiaoqiang Sun, Wenyan Tang, Lifu Wang, Zhongdao Wu, Xi Sun
Summary: The study revealed that excretory-secretory products of Angiostrongylus cantonensis fourth stage larva could induce metabolic reprogramming in macrophages, leading to alternative activation of macrophages and worsening of eosinophilic meningitis. This finding highlights the importance of helminth-derived immunoregulatory molecules in immune-related diseases and potential drug development.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Marcellus Arnold, Anna Gramza-Michalowska
Summary: Apple is a popular fruit with high levels of phenolic compounds and antioxidant activity, providing health benefits to consumers. However, enzymatic browning is a common issue in minimally processed apple products, affecting their quality. Recent studies suggest that nonconventional processing techniques and natural antibrowning agents can effectively inhibit enzymatic browning and improve product quality.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Joaquin Guerra Gomez, Jesus Devesa
Summary: Growth hormone (GH) is crucial for auditory development during the embryonic stage. Exogenous agents can trigger its release for protective purposes and stimulate other mediators to safeguard the auditory pathway. GH deficiency can lead to hearing loss or central auditory processing disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Romana Stark, Vanessa V. Santos, Bram Geenen, Agustina Cabral, Tara Dinan, Jacqueline A. Bayliss, Sarah H. Lockie, Alex Reichenbach, Moyra B. Lemus, Mario Perello, Sarah J. Spencer, Tamas Kozicz, Zane B. Andrews
Article
Endocrinology & Metabolism
G. Fernandez, A. Cabral, M. P. Cornejo, P. N. De Francesco, G. Garcia-Romero, M. Reynaldo, M. Perello
JOURNAL OF NEUROENDOCRINOLOGY
(2016)
Article
Cell Biology
Daniela Lufrano, Sebastian A. Trejo, Ramiro E. Llovera, Mariano Salgueiro, Gimena Fernandez, Valentina Martinez Damonte, F. Luis Gonzalez Flecha, Jesica Raingo, Mario R. Ermacora, Mario Perello
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Agustina Cabral, Maria P. Cornejo, Gimena Fernandez, Pablo N. De Francesco, Guadalupe Garcia-Romero, Maia Uriarte, Jeffrey M. Zigman, Enrique Portiansky, Mirta Reynaldo, Mario Perello
Article
Neurosciences
F. Agosti, S. Cordisco Gonzalez, V. Martinez Damonte, M. J. Tolosa, N. Di Siervi, H. B. Schioth, C. Davio, M. Perello, J. Raingo
Article
Endocrinology & Metabolism
Mario Perello, Agustina Cabral, Maria P. Cornejo, Pablo N. De Francesco, Gimena Fernandez, Maia Uriarte
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Maia Uriarte, Pablo Nicolas De Francesco, Gimena Fernandez, Agustina Cabral, Daniel Castrogiovanni, Tyler Lalonde, Leonard G. Luyt, Sebastian Trejo, Mario Perello
MOLECULAR NEUROBIOLOGY
(2019)
Article
Endocrinology & Metabolism
Maria Paula Cornejo, Daniel Castrogiovanni, Helgi B. Schioth, Mirta Reynaldo, Jacky Marie, Jean-Alain Fehrentz, Mario Perello
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Agustina Cabral, Gimena Fernandez, Maria J. Tolosa, Angeles Rey Moggia, Gaston Calfa, Pablo N. De Francesco, Mario Perello
MOLECULAR METABOLISM
(2020)
Review
Biochemistry & Molecular Biology
Maria P. Cornejo, Emilio R. Mustafa, Daniela Cassano, Jean-Louis Baneres, Jesica Raingo, Mario Perello
Summary: GHSR is a key molecule in neuroendocrine control, regulating various functions such as growth hormone secretion and food intake. Its signaling pathway displays basal constitutive activity and can be regulated by hormones like ghrelin and LEAP2.
Article
Biochemistry & Molecular Biology
Maria Paula Cornejo, Raphael G. P. Denis, Guadalupe Garcia Romero, Gimena Fernandez, Mirta Reynaldo, Serge Luquet, Mario Perello
Summary: Research has shown that ghrelin has a biphasic effect on energy balance by indirectly impacting energy expenditure and nutrient partitioning through its influence on food intake. The biphasic effect of ghrelin on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons in the hypothalamic arcuate nucleus, with various signals transiently counteracting ghrelin's orexigenic effect.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Endocrinology & Metabolism
Mario Perello, Suzanne L. Dickson, Jeffrey M. Zigman, Lorenzo Leggio
Summary: The stomach-derived peptide ghrelin, discovered in 1999, is an endogenous agonist of the growth hormone secretagogue receptor (GHSR) and plays key roles in various physiological functions. Its non-acylated form, desacyl-ghrelin, has a less well-understood physiological role. To establish a consistent nomenclature, experts in the field have proposed using the terms ghrelin and desacyl-ghrelin for the hormones, GHSR for the receptor, and LEAP2 for a recently recognized GHSR antagonist/inverse agonist.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Clara Ines McCarthy, Emilio Roman Mustafa, Maria Paula Cornejo, Agustin Yaneff, Silvia Susana Rodriguez, Mario Perello, Jesica Raingo
Summary: The dopamine receptor type 1 (D1R) and type 5 (D5R) exhibit high levels of constitutive activity, which can be modulated by the antipsychotic drug chlorpromazine (CPZ) as an inverse agonist, affecting calcium conductance and neuronal functions in the brain.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Gimena Fernandez, Pablo N. De Francesco, Maria P. Cornejo, Agustina Cabral, Julieta P. Aguggia, Victor J. Duque, Nilufer Sayar, Sonia Cantel, Juan Burgos, Jean-Alain Fehrentz, Rodrigo Rorato, Deniz Atasoy, Andre S. Mecawi, Mario Perello
Summary: This study provides neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the paraventricular nucleus of the hypothalamus. The results suggest that ghrelin mainly acts on neurons expressing nitric oxide synthase 1 (NOS1), and can increase c-Fos expression and phosphorylation of NOS1 in the paraventricular nucleus. Systemically injected ghrelin at a high dose increases ghrelin levels in cerebrospinal fluid and induces activation of a subset of NOS1 neurons in the paraventricular nucleus. Inhibition of nitric oxide production impairs ghrelin-induced calcium increase in corticotropin-releasing hormone neurons and partially impairs the increase of plasma glucocorticoid levels. These findings suggest that ghrelin can directly target specific neurons in the paraventricular nucleus involved in the activation of the hypothalamic-pituitary-adrenal neuroendocrine axis.
Article
Anatomy & Morphology
Maria Paula Cornejo, Pablo Nicolas De Francesco, Guadalupe Garcia Romero, Enrique L. Portiansky, Jeffrey M. Zigman, Mirta Reynaldo, Mario Perello
BRAIN STRUCTURE & FUNCTION
(2018)