Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Cell Biology
Jeeyoung Lee, Soumyadeep Dey, Praveen K. Rajvanshi, Randall K. Merling, Ruifeng Teng, Heather M. Rogers, Constance T. Noguchi
Summary: Erythropoietin (EPO) is produced in the kidney in response to hypoxia and is essential for red blood cell production. In addition to its role in erythropoiesis, EPO also increases the production of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) in non-erythroid tissue, which improves oxygen delivery. This study found that during erythroid differentiation, EPO induces neuronal nitric oxide synthase (nNOS) and that nNOS is required for a normal erythropoietic response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Wu, Yi-Cheng Tsai, Tai-Hsin Tsai, Keng-Liang Kuo, Yu-Feng Su, Chih-Hui Chang, Chih-Lung Lin
Summary: In this study, treatment with valproic acid was found to reduce the incidence of delayed cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage in male Sprague-Dawley rats. The improvement in protein expression levels appeared to reverse neuro-apoptosis, indicating a potential anti-vasospastic and neuro-protective effect of VPA through enhanced Akt and/or ERK phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Elise DeRoo, Amelia Stranz, Huan Yang, Marvin Hsieh, Caitlyn Se, Ting Zhou
Summary: This review summarizes recent findings on the pathogenesis of abdominal aortic aneurysm (AAA), including endothelial dysfunction, the impact of biomechanical stress on endothelial cells, endothelial nitric oxide synthase (eNOS) uncoupling, and endothelial cell heterogeneity. These studies contribute to a better understanding of AAA pathogenesis and may lead to the development of targeted therapeutics for this disease.
Article
Cardiac & Cardiovascular Systems
Kevin O'Gallagher, Francesca Puledda, Owen O'Daly, Matthew Ryan, Luke Dancy, Philip J. Chowienczyk, Fernando Zelaya, Peter J. Goadsby, Ajay M. Shah
Summary: This study reveals the fundamental physiological role of nNOS in regulating cerebral blood flow and functional connectivity in the human hippocampus.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kundan Solanki, Sajjan Rajpoot, Evgeny E. Bezsonov, Alexander N. Orekhov, Rohit Saluja, Anita Wary, Cassondra Axen, Kishore Wary, Mirza S. Baig
Summary: This article discusses the importance of nitric oxide synthases 1 (NOS1) and its byproduct nitric oxide (NO) in different tissues and diseases, highlighting the significance of understanding NOS1-derived NO signaling and identification of NO-metabolites for disease diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ping Wang, Fan-Zhi Kong, Xiao-Hong Hong, Li Zhang, Wan-Hong Zhao, Jin-Cui Yang, Heng Zhang
Summary: A high shortening diet may contribute to obesity and depressive behaviors, which are regulated by neuronal nitric oxide synthase (nNOS).
Article
Geriatrics & Gerontology
Huilin Yu, Ke Liao, Yu Hu, Dingyi Lv, Minghao Luo, Qian Liu, Longxiang Huang, Suxin Luo
Summary: This study investigates the role of the cGAS-STING pathway in aging-related endothelial dysfunction, demonstrating its potential as a target for the prevention of cardiovascular diseases in the elderly.
Article
Medicine, Research & Experimental
Kevin White, Yu Lu, Sofia Annis, Andrew E. Hale, B. Nelson Chau, James E. Dahlman, Craig Hemann, Alexander R. Opotowsky, Sara O. Vargas, Ivan Rosas, Mark A. Perrella, Juan C. Osorio, Kathleen J. Haley, Brian B. Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Omar F. Khan, Andrew Bader, Bernadette R. Gochuico, Majed Matar, Kevin Polach, Nicolai M. Johannessen, Haydn M. Prosser, Daniel G. Anderson, Robert Langer, Jay L. Zweier, Laurence A. Bindoff, David Systrom, Aaron B. Waxman, Richard C. Jin, Stephen Y. Chan
EMBO MOLECULAR MEDICINE
(2015)
Article
Multidisciplinary Sciences
Levy A. Reyes, James Boslett, Saradhadevi Varadharaj, Francesco De Pascali, Craig Hemann, Lawrence J. Druhan, Giuseppe Ambrosio, Mohamed El-Mahdy, Jay L. Zweier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Pharmacology & Pharmacy
Colwyn A. Headley, David DiSilvestro, Kelsey E. Bryant, Craig Hemann, Chun-An Chen, Amlan Das, Ouliana Ziouzenkova, Gregory Durand, Frederick A. Villamena
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Chemistry, Medicinal
Ilirian Dhimitruka, Yasmin Alsayed Alzarie, Craig Hemann, Alexandre Samouilov, Jay L. Zweier
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Biochemistry & Molecular Biology
Roberto Biondi, Giuseppe Ambrosio, Francesco De Pascali, Isabella Tritto, Enrico Capodicasa, Lawrence J. Druhan, Craig Hemann, Jay L. Zweier
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2012)
Article
Biochemistry & Molecular Biology
Jianjing Tong, Joseph R. Zweier, Rachael L. Huskey, Raed S. Ismail, Craig Hemann, Jay L. Zweier, Xiaoping Liu
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2014)
Article
Biochemistry & Molecular Biology
Jesus Tejero, Ashis Biswas, Mohammad Mahfuzul Haque, Zhi-Qiang Wang, Craig Hemann, Cornelius L. Varnado, Zachary Novince, Russ Hille, Douglas C. Goodwin, Dennis J. Stuehr
BIOCHEMICAL JOURNAL
(2011)
Article
Biochemistry & Molecular Biology
Xiaoping Liu, Douglas Follmer, Joseph R. Zweier, Xin Huang, Craig Hemann, Kerui Liu, Lawrence J. Druhan, Jay L. Zweier
Article
Biochemistry & Molecular Biology
Chun-An Chen, Francesco De Pascali, Ariel Basye, Craig Hernann, Jay L. Zweier
Article
Biochemistry & Molecular Biology
Francesco De Pascali, Craig Hemann, Kindra Samons, Chun-An Chen, Jay L. Zweier
Article
Biochemistry & Molecular Biology
Xiaoping Liu, Jianjing Tong, Joseph R. Zweier, Douglas Follmer, Craig Hemann, Raed S. Ismail, Jay L. Zweier
Article
Biochemistry & Molecular Biology
Murugesan Velayutham, Craig Hemann, Jay L. Zweier
FREE RADICAL BIOLOGY AND MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Haitao Li, Craig Hemann, Tamer M. Abdelghany, Mohamed A. El-Mahdy, Jay L. Zweier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Chemistry, Organic
Yangping Liu, Yuguang Song, Antal Rockenbauer, Jian Sun, Craig Hemann, Frederick A. Villamena, Jay L. Zweier
JOURNAL OF ORGANIC CHEMISTRY
(2011)
Article
Chemistry, Organic
Yuguang Song, Yangping Liu, Craig Hemann, Frederick A. Villamena, Jay L. Zweier
JOURNAL OF ORGANIC CHEMISTRY
(2013)