Article
Biochemistry & Molecular Biology
Guilherme Rodrigo R. M. Dos Santos, Ana Catarina Rezende Leite, Noelia Lander, Miguel Angel Chiurillo, Anibal Eugenio Vercesi, Roberto Docampo
Summary: Letm1 is crucial for mitochondrial Ca2+ uptake and release in Trypanosoma cruzi, affecting growth, metabolism, and cell viability.
Article
Multidisciplinary Sciences
Elisa B. Randi, Karim Zuhra, Laszlo Pecze, Theodora Panagaki, Csaba Szabo
Summary: In mammalian cells, cyanide exhibits a biphasic effect on mitochondrial Complex IV activity, stimulating it at low concentrations and inhibiting it at higher concentrations. Low levels of cyanide lead to increased cell proliferation and ATP production, while higher levels result in inhibition of cellular bioenergetics. The presence of cyanide-producing enzymes in mammalian cells suggests a regulatory role for endogenous cyanide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Nikita Arnst, Nelly Redolfi, Annamaria Lia, Martina Bedetta, Elisa Greotti, Paola Pizzo
Summary: Alzheimer's disease is a neurodegenerative illness characterized by the loss of neurons in specific brain areas. The calcium hypothesis is at the forefront of current research as a potential key pathway in Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Jasiel O. Strubbe-Rivera, Jiahui Chen, Benjamin A. West, Kristin N. Parent, Guo-Wei Wei, Jason N. Bazil
Summary: Mitochondrial cristae are dynamic invaginations of the inner membrane that play a key role in ATP production. Structural alterations caused by genetic abnormalities or detrimental environmental factors can reduce mitochondrial metabolic capacity. A computational strategy was proposed to understand how cristae are formed and how calcium phosphate granules affect mitochondrial energy metabolism.
APPLIED SCIENCES-BASEL
(2021)
Review
Physiology
David Eisner, Erwin Neher, Holger Taschenberger, Godfrey Smith
Summary: Calcium signaling is crucial for physiology. The chemistry of interactions between calcium and buffers determines the effects of calcium buffering on normal physiology, as well as the consequences of changes in disease.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Mehmet M. Altintas, Salvatore DiBartolo, Lana Tadros, Beata Samelko, Haimanot Wasse
Summary: This study aimed to elucidate mitochondrial function and associated stress pathologies in kidney disease using peripheral blood mononuclear cells (PBMCs) of hemodialysis patients. The analysis revealed a significant reduction in mitochondrial respiration in ESKD patient PBMCs, correlated with changes in key bioenergetic parameters and protein expression levels. The findings suggest a link between mitochondrial dysfunction and ESKD, with potential therapeutic implications.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Amit S. Korde, William F. Maragos
Summary: The research findings indicate that NMDA(m) activation modulates mitochondrial bioenergetics through both Ca2+-dependent and Ca2+-independent mechanisms.
Review
Biochemistry & Molecular Biology
Lauren L. Walkon, Jasiel O. Strubbe-Rivera, Jason N. Bazil
Summary: Mitochondrial calcium plays a dual role, with low levels being essential for ATP production and high levels leading to mitochondrial dysfunction. In moderate amounts, calcium inhibits ATP synthesis. The mechanism of mitochondrial dysfunction during calcium overload remains unclear, but it may involve changes in mitochondrial ultrastructure and enzyme activity.
Article
Biology
Stefano Bettinazzi, Liliana Milani, Pierre U. Blier, Sophie Breton
Summary: The study explores the impact of sex-specific mitochondrial evolution on gamete bioenergetics in DUI and SMI bivalve species. The findings suggest reorganized bioenergetic pathways in DUI gametes compared to SMI gametes, resulting in decreased enzymatic capacity in DUI sperm, especially at the terminus of the electron transport system. This bioenergetic remodelling fits a reproductive strategy that does not require high energy input and could potentially link with the preservation of the paternally transmitted mitochondrial genome in DUI species. The origin of this phenotype, whether from positive or relaxed selection acting on DUI sperm, remains uncertain.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Sarita Limbu, Benjamin L. Prosser, William J. Lederer, Christopher W. Ward, Mohsin S. Jafri
Summary: This study explores the interaction between length-dependent changes in calcium buffering by troponin and stretch-activated X-ROS calcium signaling in cardiomyocytes. The results suggest that the increase in myoplasmic calcium buffering by troponin C during myocyte stretching largely offsets the increase in calcium release from the sarcoplasmic reticulum induced by X-ROS signaling. The experimental and modeling approaches used in this study help further define the roles of X-ROS signaling and troponin-dependent calcium buffering in shaping myoplasmic calcium transient.
Article
Neurosciences
Azahara Civera-Tregon, Laura Dominguez, Paula Martinez-Valero, Claudia Serrano, Alex Vallmitjana, Raul Benitez, Janet Hoenicka, Jorgina Satrustegui, Francesc Palau
Summary: The loss of GDAP1 leads to mitochondrial and calcium homeostasis disruption in axons, affecting bioenergetic status and axonal transport. This study provides insights into the cellular mechanisms associated with axonal degeneration in GDAP1-related neuropathies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Sport Sciences
Erik D. Marchant, Nathan D. Marchant, Robert D. Hyldahl, Jayson R. Gifford, Michael W. Smith, Chad R. Hancock
Summary: This study aimed to investigate the effects of ultraendurance exercise on the bioenergetic status of muscle. The findings showed that completing a 100 km ultramarathon led to significant mitochondrial impairment in muscle, which rapidly recovered within two days. Blood markers also showed changes after the run but partially recovered within 48 hours.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Neurosciences
Angela Maria Casaril, Robert Dantzer, Carlos Bas-Orth
Summary: Depression is a leading cause of disability globally, and peripheral inflammation may increase the risk of depressive episodes and impact brain function. In neurodegenerative and neuroinflammatory diseases, inflammation negatively affects mitochondrial health, potentially leading to oxidative stress, energy deficits, and neuronal death. Further research is needed to understand the relationship between neuroinflammation, mitochondrial dysfunction, and bioenergetic failure in inflammation-associated depression.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Kelsey H. Fisher-Wellman, James T. Hagen, P. Darrell Neufer, Miki Kassai, Myles C. Cabot
Summary: Sphingolipids are a unique class of lipids that play a key role in apoptosis by interacting with mitochondria and initiating signaling cascades that lead to cell death.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Lauren H. Fairley, Imane Lejri, Amandine Grimm, Anne Eckert
Summary: Abnormal tau build-up is a hallmark of Alzheimer's disease and other neurodegenerative diseases. Mitochondrial dysfunction is associated with tau pathology. This study investigated the effects of spermidine, a neuroprotective polyamine, on mitochondrial function in a cellular model of tauopathy. The results showed that spermidine improved mitochondrial function and restored tau-induced impairments in mitophagy, suggesting that spermidine supplementation might be a potential therapeutic approach for tau-related mitochondrial impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ranjan K. Pradhan, Eric O. Feigl, Mark W. Gorman, George L. Brengelmann, Daniel A. Beard
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Review
Physiology
R. K. Pradhan, V. S. Chakravarthy
Article
Biophysics
Ranjan K. Pradhan, Daniel A. Beard, Ranjan K. Dash
BIOPHYSICAL JOURNAL
(2010)
Article
Biophysics
Ranjan K. Pradhan, Feng Qi, Daniel A. Beard, Ranjan K. Dash
BIOPHYSICAL JOURNAL
(2011)
Article
Biochemistry & Molecular Biology
Feng Qi, Ranjan K. Pradhan, Ranjan K. Dash, Daniel A. Beard
Article
Biophysics
Christoph A. Blomeyer, Jason N. Bazil, David F. Stowe, Ranjan K. Pradhan, Ranjan K. Dash, Amadou K. S. Camara
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2013)
Article
Biophysics
Age D. Boelens, Ranjan K. Pradhan, Christoph A. Blomeyer, Amadou K. S. Camara, Ranjan K. Dash, David F. Stowe
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2013)
Article
Chemistry, Physical
X. Li, R. K. Dash, R. K. Pradhan, F. Qi, M. Thompson, K. C. Vinnakota, F. Wu, F. Yang, D. A. Beard
JOURNAL OF PHYSICAL CHEMISTRY B
(2010)
Article
Biology
Ranjan K. Pradhan, V. S. Chakravarthy
JOURNAL OF THEORETICAL BIOLOGY
(2009)
Article
Computer Science, Artificial Intelligence
Rohit Gandrakota, V. S. Chakravarthy, Ranjan K. Pradhan
NEURAL COMPUTATION
(2010)
Article
Multidisciplinary Sciences
Ranjan K. Pradhan, Feng Qi, Daniel A. Beard, Ranjan K. Dash
Article
Biology
Ranjan K. Pradhan, V. S. Chakravarthy
MATHEMATICAL BIOSCIENCES
(2007)
Article
Peripheral Vascular Disease
Ranjan K. Pradhan, V. S. Chakravarthy, Anil Prabhakar
MICROVASCULAR RESEARCH
(2007)
Article
Engineering, Electrical & Electronic
M Maitra, RK Pradhan
IETE JOURNAL OF RESEARCH
(2005)