Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 43, Issue 4, Pages 425-435Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-011-9367-2
Keywords
Heat shock proteins; Cytochrome c oxidase; Myocardial ischemia; Mitochondria; ATP-dependent enzyme inhibition
Categories
Ask authors/readers for more resources
Induction of heat shock proteins (hsp) has been shown to protect cells from ischemia by providing transient tolerance against myocardial injury and improving postischemic functional recovery. Attenuation of ATP depletion and earlier restoration of ATP content on reperfusion are thought to play a role in this scenario. Hsp induction is accompanied by altered enzyme activity of the respiratory chain, the major generator of ATP under physiological conditions. This report addresses the question whether processing and final assembly of the active holoenzyme cytochrome c oxidase (CcO, complex IV), member of the respiratory chain, is compromised under hypoxic conditions unless protected by stress proteins. Special focus is laid on function of the enzyme's subunits and importance of cellular energy availability and maintenance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available