Encountering unpredicted off-target effects of pharmacological inhibitors

SP600125 Inhibits Cap-dependent Translation Independently of the c-Jun N-terminal Kinase Pathway

(2011) Masatoshi Ito et al.   CELL STRUCTURE AND FUNCTION

Drug discovery and development focusing on existing medicines: drug re-profiling strategy

(2011) T. Mizushima   JOURNAL OF BIOCHEMISTRY

Targeted therapies of gastrointestinal stromal tumors (GIST)—The next frontiers

(2010) Stefan Duensing et al.   BIOCHEMICAL PHARMACOLOGY

Diverse Physiological Functions of MKK4 and MKK7 during Early Embryogenesis

(2010) Y. Asaoka et al.   JOURNAL OF BIOCHEMISTRY

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Blockage by SP600125 of Fc  Receptor-Induced Degranulation and Cytokine Gene Expression in Mast Cells is Mediated Through Inhibition of Phosphatidylinositol 3-Kinase Signalling Pathway

(2008) S. Tanemura et al.   JOURNAL OF BIOCHEMISTRY

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY