Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Biochemistry & Molecular Biology
Mulin Liu, Hexin Wen, Lugen Zuo, Xue Song, Zhijun Geng, Sitang Ge, Yuanyuan Ge, Rong Wu, Shiyuan Chen, Chaowen Yu, Yong Gao
Summary: This study investigated the effects of Bryo-1 on intestinal ischemia/reperfusion (I/R) injury and its mechanism. The results showed that Bryo-1 improved the intestinal barrier dysfunction caused by I/R, reduced oxidative stress damages and inflammation, and activated Nrf2/HO-1 signaling. These findings suggest that Bryo-1 protects intestines against I/R-induced injury through intestinal barrier protection and inhibition of inflammation and oxidative stress partly via Nrf2/HO-1 signaling.
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Zhenqian Lv, Feng'e Wang, Xingfeng Zhang, Xiting Zhang, Jing Zhang, Ran Liu
Summary: Etomidate (Eto) attenuated myocardial ischemia reperfusion injury (MIRI) by inhibiting ferroptosis via the Nrf2 pathway, demonstrating anti-inflammatory and anti-fibrotic effects in MIRI rats.
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wen An, Ju-Seop Kang
Summary: Metformin can alleviate hepatic and myocardial injury induced by hepatic ischemia-reperfusion by inhibiting oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Jun Pei, Xiaomao Tian, Chengjun Yu, Jin Luo, Jie Zhang, Yi Hua, Guanghui Wei
Summary: This study identified 30 differentially expressed genes associated with oxidative stress in renal ischemia reperfusion injuries. The key genes GPX3 and GSTT1 were found to be related to oxidative stress and immune cell infiltration. These findings provide new potential biomarkers for the early diagnosis and treatment of renal IRIs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gustavo Sampaio de Holanda, Samuel dos Santos Valenca, Amabile Maran Carra, Renata Cristina Lopes Lichtenberger, Bianca de Castilho, Olavo Borges Franco, Joao Alfredo de Moraes, Alberto Schanaider
Summary: Acute mesenteric ischemia and reperfusion injury is a complex and lethal mechanism involving disruption of cellular microcirculation and mitochondrial damage. Fluorescent molecular probes have been shown to be highly efficient in monitoring the concentrations and locations of ROS and RNS.
Article
Biochemistry & Molecular Biology
Ganesan Padmavathi, Kunka Mohanram Ramkumar
Summary: Ischemia/reperfusion injury (IRI) is caused by oxidative stress from lack of blood supply, leading to sterile inflammation, cell death, and microvascular dysfunction. Dysregulation of the Nrf2 pathway is a significant factor in IRI, with miRNAs regulating Nrf2 expression. Compounds that modulate Nrf2-regulating miRNAs have shown protective effects against IRI in various organs.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Pharmacology & Pharmacy
Minglei Bi, Danyi Li, Jin Zhang
Summary: Ischemia-reperfusion injury (IRI) is a common pathological process after organ transplantations, and the damage caused by IRI is often ignored. Curcumin, a polyphenol compound, has been shown to have protective effects against IRI through its anti-oxidative stress, anti-inflammation and anti-apoptosis properties. However, there are still controversies about the underlying mechanisms of curcumin's effects on IRI. This review aims to summarize the protective role of curcumin against IRI and clarify its underlying mechanisms, providing a novel idea for the therapy of IRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Consuelo Pasten, Mauricio Lozano, Jocelyn Rocco, Flavio Carrion, Cristobal Alvarado, Jessica Liberona, Luis Michea, Carlos E. Irarrazabal
Summary: The study found that aminoguanidine (AG) acts as an antioxidant compound and plays a renal protective role during renal ischemia-reperfusion injury (IRI) by inhibiting oxidative stress and inflammation, thus restoring kidney function.
Article
Biochemistry & Molecular Biology
Manigandan Nagarajan, Gobichettipalayam Balasubramaniam Maadurshni, Jeganathan Manivannan
Summary: This study found that exposure to BPA exacerbates hypertension-induced pathological changes, including renal fibrosis, oxidative stress, elevated angiotensin-converting enzyme activity, dysfunction of antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities, and expression of inflammatory factors. In addition, high levels of BPA have dose-dependent effects on kidney cells, including oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Therefore, a precise investigation of BPA exposure in hypertensive populations is highly recommended during risk assessment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiping Bao, Qiang Zhang, Yu Li, Chen Nie
Summary: In this study, the role of circDLGAP4 in Parkinson's disease (PD) was investigated. The results showed that circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus alleviating neuronal injury in PD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Lina Yang, Tianwei He, Yanming Yu
Summary: This study found that uric acid induces kidney injury by inducing IL-17 expression, and treatment with anti-IL-17 antibody can alleviate uric acid-induced kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
