Review
Engineering, Biomedical
Hui Gao, Qian Pan, Weiqiang Dong, Yongchang Yao
Summary: This review provides an overview of the anatomical composition, microstructure, and biomechanical properties of the osteochondral interface, as well as the latest research progress and influencing factors related to osteochondral regeneration.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Engineering, Biomedical
Wenying Wei, Honglian Dai
Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Shenqiang Wang, Sheng Zhao, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: 3D printing technology has great potential in the field of tissue engineering, allowing the fabrication of biomimetic tissue structures for personalized therapy of various diseases. This review introduces the recently developed 3D printing techniques and summarizes their applications in cartilage, bone, and osteochondral tissue regeneration.
Review
Medicine, Research & Experimental
Ziyang Zhou, Jin Cui, Shunli Wu, Zhen Geng, Jiacan Su
Summary: Osteoarthritis is a common joint disease that causes physical and psychological harm to patients and burdens the healthcare system. Tissue engineering has been focusing on cartilage repair, with silk fibroin as a promising biomaterial due to its unique properties and capabilities for functional modification.
Article
Engineering, Biomedical
Gagan K. Jalandhra, Thomas G. Molley, Tzong-tyng Hung, Iman Roohani, Kristopher A. Kilian
Summary: This study developed a unique printing platform that integrates soft and hard materials concurrently through freeform printing of mineralized constructs within tunable micro-gel suspensions containing living cells. By tuning the microgel stiffness and filler content, chondrogenesis and osteogenesis can be differentially directed within the same construct, enabling the fabrication of osteochondral interfaces in a single step. This versatile one-pot biofabrication approach has the potential to aid in bone disease modeling and tissue engineering.
ACTA BIOMATERIALIA
(2023)
Review
Pharmacology & Pharmacy
Markel Lafuente-Merchan, Sandra Ruiz-Alonso, Fatima Garcia-Villen, Idoia Gallego, Patricia Galvez-Martin, Laura Saenz-del-Burgo, Jose Luis Pedraz
Summary: This article reviews the advantages of using 3D bioprinting techniques for osteochondral regeneration, discusses the commonly used biomaterials, cell types, and active molecules, and considers the most recent promising results.
Article
Biochemistry & Molecular Biology
Frederico Barbosa, Frederico Castelo Ferreira, Joao Carlos Silva
Summary: Osteochondral tissue engineering is a promising strategy for treating diseases such as osteoarthritis. However, current research focuses mainly on the structural and mechanical properties of the tissue, while neglecting its piezoelectric properties. This review summarizes the recent advances in the application of piezoelectric electrospun scaffolds for replacing damaged osteochondral tissue and promoting its regeneration, and discusses the current challenges and future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Giovanna Rizzo, Nicoletta Palermo, Ugo D'Amora, Salvatore Oddo, Salvatore Pietro Paolo Guglielmino, Sabrina Conoci, Marta Anna Szychlinska, Giovanna Calabrese
Summary: Articular cartilage has limited self-healing capacity, leading to osteoarthritis. Osteochondral engineering, combining cells, biomaterials, and biomolecules, is effective for regeneration. Peptides, such as growth factor mimetics, show promise in tissue repair and exhibit various functions. Phage display technology is a powerful tool for obtaining functional peptides at a low cost.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Andrea Schwab, Marinus A. Wesdorp, Jietao Xu, Florencia Abinzano, Claudia Loebel, Marc Falandt, Riccardo Levato, David Eglin, Roberto Narcisi, Martin J. Stoddart, Jos Malda, Jason A. Burdick, Matteo D'Este, Gerjo J. V. M. Van Osch
Summary: This study investigates the influence of various physicochemical properties of hydrogels on cell migration and related tissue formation using in vitro, ex vivo and in vivo models.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Materials Science, Biomaterials
Nuh Yildirim, Amina Amanzhanova, Gulzada Kulzhanova, Fariza Mukasheva, Cevat Erisken
Summary: Osteochondral defects are a major clinical problem, and the importance of the tidemark, a selectively permeable membrane in the osteochondral interface, has been largely overlooked in previous research. This review focuses on the structure, composition, and function of the osteochondral interface, as well as the challenges in regenerative engineering. The formation of the tidemark, which separates the avascular and vascular regions of the interface, is a major challenge in regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Robert Choe, Eoin Devoy, Erfan Jabari, Jonathan D. Packer, John P. Fisher
Summary: Osteoarthritis is a common musculoskeletal disorder that causes joint pain and deformity, significantly affecting patients' quality of life. The osteochondral unit is composed of three layers, each contributing to unique biomechanical properties. Understanding the role of the osteochondral interface is important for tissue engineering advancements.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Article
Engineering, Biomedical
Joseph A. M. Steele, Axel C. Moore, Jean-Philippe St-Pierre, Seth D. McCullen, Adam J. Gormley, Conor C. Horgan, Cameron RM. Black, Christoph Meinert, Travis Klein, Siamak Saifzadeh, Roland Steck, Jiongyu Ren, Maria A. Woodruff, Molly M. Stevens
Summary: This study designed and fabricated a porous zonal microstructured scaffold that mimics the structure and mechanical properties of articular cartilage. In vitro experiments showed that chondrocyte-seeded scaffolds could accumulate extracellular matrix. Repair experiments conducted on animal models demonstrated the stable retention, osteointegration, and prolonged degradation of the scaffold. Although the histological scoring did not show superiority over the control group, this may be due to limited degradation of the implant.
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Review
Materials Science, Biomaterials
Yue Zhu, Jialin Chen, Haoyang Liu, Wei Zhang
Summary: In this review, the authors systematically summarize the different types and physicochemical properties of photo-cross-linked hydrogels and explore the biological properties modulated through the incorporation of additives. The applications of photo-cross-linked hydrogels in cartilage and osteochondral repair are compiled and the current limitations and future perspectives of these hydrogels are also discussed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Sarah Davis, Marta Roldo, Gordon Blunn, Gianluca Tozzi, Tosca Roncada
Summary: Articular cartilage is crucial for joint function, but its limited self-repairing capacity poses a challenge for restoring its mechanical properties. Tissue engineering techniques using stem cells, growth factors, and biomaterials show promise for treating cartilage defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)