Review
Biochemistry & Molecular Biology
Karen R. Jonscher, Winyoo Chowanadisai, Robert B. Rucker
Summary: Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging, and can attenuate clinically relevant dysfunctions related to ischemia, inflammation, and lipotoxicity. As an enzymatic cofactor or accessory factor, PQQ modulates lactate acid and other dehydrogenases to enhance NAD+-dependent sirtuin activity and mediate mitochondrial functions.
Article
Engineering, Chemical
Chongrong Ke, Yang Ren, Ping Gao, Jian Han, Yong Tao, Jianzhong Huang, Xinwei Yang
Summary: This study developed a two-step process for the large-scale separation and purification of PQQ from crude fermentation broth, achieving high purity PQQ crystals. The process involved pretreatment, resin purification, and standardized operational parameters for scaled-up PQQ purification.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Review
Cell Biology
Sara S. Procknow, Beth A. Kozel
Summary: Elastin provides elasticity to tissues such as the lung, blood vessels, and skin, but the mechanisms regulating its production are not fully understood. Studying the expression of the ELN gene may help intervene in rare diseases and potentially replace age-related losses by re-initiating elastin production.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen
Summary: This study demonstrates that dietary supplementation of PQQ can protect against ovarian dysfunction caused by alkylating agents, by increasing ovarian weight and size, restoring estrous cycle period, and improving fertility parameters in mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kui Wang, Xiao-Yan Wang, Guo-Jie Gao, Mi-Ni Wang, Ying-Ying Yu, Siyang Xing, Bolin Zhu
Summary: A pH-triggered transition from micellar aggregation to a host-guest complex was achieved by supramolecular interactions between calixpyridinium and pyrroloquinoline quinone disodium salt (PQQ-2Na), accompanied by a color change. This transition was further studied as a controllable-release model due to the low toxicity of the involved compounds.
Review
Biochemistry & Molecular Biology
Nur Syafiqah Mohamad Ishak, Kazuto Ikemoto
Summary: Obesity is a global health concern with increasing prevalence. Pyrroloquinoline quinone (PQQ), found naturally in some foods and available as a dietary supplement, has potential health benefits due to its antioxidant and anti-inflammatory properties. PQQ influences mitochondrial function, which is associated with obesity complications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Medicine, Research & Experimental
Junjie Liu, Tianhao Yang, Zishen Huang, Huifang Chen, Yinshan Bai
Summary: MicroRNAs are a type of small RNA that regulate gene expression at the post-transcriptional level by targeting the 3' UTR of mRNAs. Recent research has shown that mature miRNAs can be found in the nucleus and play a role in gene transcription and epigenetic regulation, particularly in cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
S. A. Masudul Hoque, Takashi Umehara, Tomoko Kawai, Masayuki Shimada
Summary: This study elucidated the negative effects of ROS on mitochondrial functions in FSH-stimulated granulosa cells during follicular development, and investigated the potential of PQQ treatment to ameliorate these effects. PQQ treatment reduced ROS levels and oxidative stress, improved cell viability and function, and increased the number of ovulated oocytes and pups per delivery.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
I. Cody MacDonald, Travis R. Seamons, Jonathan C. Emmons, Shwan B. Javdan, Tara L. Deans
Summary: Expansion of genetic toolkits for prokaryotic synthetic biology can enhance gene expression dynamics. Integrating the eukaryotic transcription factor QF into E. coli allows for the construction of genetic devices with complex functions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Eduardo Lujan-Soto, Paola Aguirre de la Cruz, Vasti T. Juarez-Gonzalez, Jose L. Reyes, Maria de la Paz Sanchez, Tzvetanka D. Dinkova
Summary: In recent years, miR528 has been found to play important roles in plant development and stress response. This study examined the transcription regulation and molecular mechanisms of MIR528 expression in maize, revealing conserved transcription factor binding sites and demonstrating the up-regulation of miR528 expression by exogenous nitrate and auxin treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kunie Yoshinaga-Sakurai, Toby G. Rossman, Barry P. Rosen
Summary: AS3MT is a human enzyme that catalyzes arsenic biotransformations and is considered to contribute to arsenic-related diseases. The expression of AS3MT is tissue/cell type-specific, and the transcriptional regulation mechanism of the gene is still unknown. In this study, the core promoter region of the human AS3MT gene is defined, and a GC box in the promoter is identified as a site where the transcription factor Sp1 binds, indicating the involvement of regulatory elements in AS3MT gene expression.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
ShaoPei Li, Aruna Raja, Meissam Noroozifar, Kagan Kerman
Summary: Parkinson's disease (PD) is associated with the aggregation and misfolding of α-synuclein (α-syn) protein. A proof-of-concept study found that pyrroloquinoline quinone (PQQ) can effectively prevent ROS formation and fibrillation of α-syn-119 in the presence of Cu(II), suggesting PQQ as a potential multitarget therapeutic agent for PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Microbiology
Kai P. Hussnaetter, Magnus Philipp, Kira Muntjes, Michael Feldbruegge, Kerstin Schipper
Summary: Heterologous protein production is achieved through unconventional secretion in the fungal model microorganism Ustilago maydis. By utilizing the kinase Don3 as a gatekeeper for export control, regulation is successfully established at both transcriptional and post-translational levels, allowing for efficient production and secretion of desired protein products.
Article
Multidisciplinary Sciences
Lorena Di Pietro, Marta Barba, Daniela Palacios, Federica Tiberio, Chiara Prampolini, Mirko Baranzini, Ornella Parolini, Alessandro Arcovito, Wanda Lattanzi
Summary: The research suggests that sequence changes in the RUNX2 locus may have contributed to human skull globularization through altering binding of Znf263, miRNA affinity, and regulation of RUNX2 expression and related RNAs. These changes could have led to adaptive phenotypic evolution of RUNX2, explaining the delayed suture fusion and globular skull shape in modern humans.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Thuy Minh Nguyen, Kotone Naoki, Naoya Kataoka, Minenosuke Matsutani, Yoshitaka Ano, Osao Adachi, Kazunobu Matsushita, Toshiharu Yakushi
Summary: This study characterized the PQQ-DH9 of Gluconobacter sp. strain CHM43, showing its high oxidation activity towards secondary alcohols but lower activity on linear substrates compared to GLDH. The experimental results of gene expression suggest the important role of PQQ-DH9 in the cell membrane.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)