Review
Immunology
Lina Scheithauer, Mustafa Safa Karagoez, Benjamin. E. E. Mayer, Michael Steinert
Summary: This research describes the interaction between the pathogenic bacterium L. pneumophila and host cells, which leads to host cell manipulation and tissue colonization. The study also reveals the interaction between two virulence factors of L. pneumophila and multiple proteins, including bacterial flagellin and host collagen, highlighting their roles in virulence regulation, host tissue degradation, and immune evasion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christopher I. Graham, Palak G. Patel, Jennifer R. Tanner, Jacqueline Hellinga, Teassa L. MacMartin, Georg Hausner, Ann Karen C. Brassinga
Summary: PsrA in Legionella pneumophila is a host-specific requirement for optimal temporal progression of the intracellular lifecycle in A. castellanii, affecting bacterial intracellular growth and transmissive cyst formation.
MOLECULAR MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiao-Yong Zhan, Jin-Lei Yang, Xuefu Zhou, Yi-Chao Qian, Ke Huang, Honghua Sun, Huacheng Wang, Yang Leng, Bihui Huang, Yulong He
Summary: SidJ family proteins play a crucial role in the virulence of Legionella pneumophila, regulating cellular processes through a unique phosphoribosyl ubiquitination mechanism. The evolution of the sidJ gene is shaped by intragenic recombination and strong positive selection, potentially impacting the balance of ubiquitin ligase activity in different hosts of the bacteria.
Article
Microbiology
Ramon Hochstrasser, Sarah Michaelis, Sabrina Brulisauer, Thomas Sura, Mingzhen Fan, Sandra Maass, Dorte Becher, Hubert Hilbi
Summary: The environmental bacterium Legionella pneumophila uses a regulatory network to control bacterial motility, virulence, and biofilm structure, and regulates the migration of amoebae through biofilms and the formation of bacterial clusters.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biology
Marie Schwerdtner, Annika Skalik, Hannah Limburg, Jeff Bierwagen, Anna Lena Jung, Jens Dorna, Andreas Kaufmann, Stefan Bauer, Bernd Schmeck, Eva Boettcher-Friebertshaeuser
Summary: Many viruses require protease activation to infect cells, and host proteases are potential targets for drug development. TMPRSS2 has been identified as a major activating protease for influenza A virus (IAV) and coronaviruses. This study found that Legionella pneumophila upregulates the expression of TMPRSS2 in human airway cells, which may enhance the activation and replication of IAV during co-infection.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biotechnology & Applied Microbiology
Joseph Saoud, Thangadurai Mani, Sebastien P. Faucher
Summary: Legionella pneumophila is often found in water systems, such as hot water distribution systems, and heat treatment is used to reduce its concentration. However, Lp quickly recolonizes these systems, indicating an efficient heat shock response. This study shows that the protease Tsp and the two-component system CpxRA are crucial for Lp's survival under thermal stress in water and within host cells.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joseph Saoud, Thangadurai Mani, Petra Rohrbach, Sebastien P. Faucher
Summary: Legionella pneumophila is a pathogenic bacterium causing severe pneumonia in humans. Its replication and virulence are influenced by host immune response, secretion system, and proteases.
CANADIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joseph Saoud, Thangadurai Mani, Petra Rohrbach, Sebastien P. Faucher
Summary: Legionella pneumophila is a Gram-negative bacterium that causes Legionnaires' disease. The bacterium replicates in water systems and amoebas/ciliates, and in humans it replicates in lung cells, causing severe pneumonia. The bacteria's ability to avoid host immune responses and its production of specific enzymes are crucial for its virulence.
CANADIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Immunology
Jackson A. Campbell, Nicholas P. Cianciotto
Summary: This study reveals that Cas2 protein in Legionella pneumophila promotes intracellular infection and thermal tolerance through regulating the expression of HspC2 protein. These findings provide new insights into the noncanonical functions of CRISPR-Cas proteins.
INFECTION AND IMMUNITY
(2022)
Article
Biotechnology & Applied Microbiology
Daniela Glazar Ivce, Dobrica Roncevic, Marina Santic, Arijana Cenov, Dijana Tomic Linsak, Vladimir Micovic, Drazen Lusic, Marin Glad, Davor Ljubas, Darija Vukic Lusic
Summary: The study investigated the prevalence of Legionella pneumophila in the drinking water distribution system of PGK County in Croatia, coupled with the incidence of legionnaires' disease. Results showed a higher proportion of positive samples in health and aged care facilities, an increasing trend in reported legionnaires' disease cases, and suggested the implementation of a mandatory Legionella environmental surveillance program.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Economics
Harvey S. James
Summary: This paper uses multilevel regression analysis to investigate the individual, institutional, and other-regarding factors that affect ethical decision-making, based on data from the World Values Survey in 53 countries. The findings suggest that perceptions of trustworthiness and fairness in others are positively correlated with tolerance of unethical behavior, particularly in countries with moderate institutional quality. High institutional quality moderates the negative relationship between perceptions and ethical attitudes. These findings confirm the relevance of other-regarding factors and highlight the importance of quality institutions in supporting ethical decision-making.
REVIEW OF SOCIAL ECONOMY
(2023)
Article
Philosophy
Shannon Hayes
Summary: This article explores the concept of the "physiological blind spot" as a metaphor for the unconscious and the invisible world, using the works of Merleau-Ponty, Proust, and Barthes. It examines the shared themes of questioning existence and observation of others across these different texts.
RESEARCH IN PHENOMENOLOGY
(2022)