Journal
JOURNAL OF BACTERIOLOGY
Volume 192, Issue 18, Pages 4786-4789Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00371-10
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Funding
- National Science Foundation
- National Institutes of Health
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MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity.
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