Journal
JOURNAL OF BACTERIOLOGY
Volume 190, Issue 13, Pages 4749-4753Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01988-07
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Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.
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