Journal
JOURNAL OF BACTERIOLOGY
Volume 191, Issue 4, Pages 1343-1348Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01074-08
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Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [17819, 2107, 843]
- CONICET
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Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the pump and an increased susceptibility to microcin J25.
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