Article
Oncology
Yun Shi, Jing Zhu, Jin-Qing Liu, Fatemeh Talebian, Mingsong Li, Xue-Feng Bai
Summary: The cell surface protein CD24 has been found to regulate the generation and functions of Treg cells, which play a crucial role in autoimmune diseases. While CD24 does not globally affect the thymic generation of Treg cells, it is abundantly expressed on Treg cells and treatment with CD24 antibody enhances their suppressive functions. CD24-deficient Treg cells exhibit increased suppressive functions and are more efficient in inhibiting the development of experimental autoimmune encephalomyelitis (EAE) in mice.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Saisai Ren, Xiaorong Zhang, Hongbing Guan, Lihong Wu, Miao Yu, Dan Hou, Yongyong Yan, Xuechun Fang
Summary: The study found that the probiotic Lactobacillus acidipiscis in the intestine can suppress the development of multiple sclerosis by inducing the generation of regulatory T cells. This helps to inhibit the progression of the disease and shows potential for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lin Luo, Xianzhen Hu, Michael L. Dixon, Brandon J. Pope, Jonathan D. Leavenworth, Chander Raman, William R. Meador, Jianmei W. Leavenworth
Summary: The research demonstrates the crucial role of Blimp1 in maintaining T-FR cells and Ab responses in EAE, with dysregulated T-FR cells and Ab responses promoting CNS autoimmunity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jonathan Charaix, Alexia Borelli, Jeremy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Serge, Magali Irla
Summary: This study reveals that Aire regulates the suppressive signature of recirculating T-reg in the thymus. Specifically, Aire controls the suppressive function of recirculating T-reg by regulating the expression of mTEC, which are responsible for restimulating T-reg.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mohamed A. El-Emam, Samar El Achy, Dalaal M. Abdallah, Hanan S. El-Abhar, Mennatallah A. Gowayed
Summary: The study suggests that the use of the anticholinesterase and cholinergic drug galantamine with or without exercise can effectively reduce disease scores and improve motor performance in the management of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). The drug can inhibit inflammation and apoptosis, promote remyelination of neurons, and exercise can enhance the drug's effects.
Article
Cell Biology
Chun Wang, Jingshu Yang, Ling Xie, Kaidireya Saimaier, Wei Zhuang, Mengyao Han, Guangyu Liu, Jie Lv, Guangfeng Shi, Ning Li, Changsheng Du
Summary: This study found that methyl butyrate (MB) can alleviate symptoms of experimental autoimmune encephalomyelitis (EAE) in mice, with an observed decrease in inflammatory T cells in the central nervous system and intestinal lamina propria. MB also promoted regulatory T cells and IL-10 secretion. The mechanism of action may involve the indirect suppression of Th17 cells through inhibition of IL-6 secretion and upregulation of Maf gene expression.
Article
Immunology
Daniel Hwang, Alexandra Boehm, Abdolmohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric
Summary: D-mannose supplementation attenuates pathology in diabetes and airway inflammation models by modifying cellular energy metabolism and inducing T regulatory cells. In experiments on EAE, it delayed disease onset, reduced severity, and prevented relapses, suggesting potential as a complementary therapy for MS.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gil-Ran Kim, Won-Ju Kim, Sangho Lim, Hong-Gyun Lee, Ja-Hyun Koo, Kyung-Ho Nam, Sung-Min Kim, Sung-Dong Park, Je-Min Choi
Summary: The study demonstrates that a novel chimeric CTLA-4 signaling peptide can induce regulatory T cells effectively in vivo, showing potential therapeutic effects for autoimmune diseases such as multiple sclerosis.
Article
Biochemistry & Molecular Biology
Haishan Li, Yingying Zeng, Shunchang Luo, Zhenhua Li, Fang Huang, Zonghua Liu
Summary: Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS) that mainly affects young adults. CD4+ T cells play a significant role in the inflammatory processes of MS. Ferroptosis, a newly discovered form of programmed cell death, has been found to be associated with CD4+ T cells, but its impact on MS remains unclear.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Songsong Lu, Rui Kang, Yongchao Wang, Mengjie Zhu, Lei Zhao, Qinzhu Xu, Ying Song, Chen Liu
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2020)
Article
Cell Biology
Sen Yu, Jie Zhang, Chen Liu, Xiuyuan Sun, Xuewen Pang, Yan Li, Xiaohong Sun, Rong Jin, Yu Zhang
CELLULAR IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Chen Liu, Lijuan Xu, Changsheng Xia, Yan Long, Caoyi Liu, Songsong Lu, Ying Song
HEPATOLOGY RESEARCH
(2020)
Article
Immunology
Yan Long, Xiaotao Zhao, Changsheng Xia, Xinyu Liu, Chunhong Fan, Chen Liu
Summary: Helios(+)FoxP3(+)Tregs play a crucial role in the disease activity of UC and may be influenced by EBV infection. These Tregs are significantly decreased in active UC and are inversely correlated with inflammatory markers. Furthermore, there is a negative correlation between Helios(+)FoxP3(+)Tregs and EBV viral loads.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Immunology
Yan Long, Chengbin Wang, Changsheng Xia, Xiaoxu Li, Chunhong Fan, Xiaotao Zhao, Chen Liu
IMMUNOLOGY LETTERS
(2020)
Article
Biology
Qiankun Bao, Bangying Zhang, Ya Suo, Chen Liu, Qian Yang, Kai Zhang, Ming Yuan, Meng Yuan, Yue Zhang, Guangping Li
Article
Immunology
Yan Long, Changsheng Xia, Lijuan Xu, Caoyi Liu, Chunhong Fan, Huizhang Bao, Xiaotao Zhao, Chen Liu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Songsong Lu, Man Han, Ying Song, Chen Liu
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Immunology
Y. Long, X. Zhao, Chang Liu, C. Xia, Chen Liu
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Immunology
Chen Liu, Sen Yu, Rong Jin, Yan Long, Songsong Lu, Ying Song, Xiuyuan Sun, Xiao-Hong Sun, Yu Zhang
JOURNAL OF AUTOIMMUNITY
(2020)
Article
Immunology
Changsheng Xia, Caoyi Liu, Yanying Liu, Yan Long, Lijuan Xu, Chen Liu
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Immunology
Yan Long, Changsheng Xia, Yuanyuan Sun, Yinting Ma, Lijuan Xu, Ying Song, Chen Liu
Summary: The study showed that circulating Tph cells are elevated in active UC patients and are associated with disease activity. The expression of Tph and ICOS was significantly correlated with disease severity and serum CRP levels in active UC patients. Tph levels were also associated with new memory B cells, plasmablasts, serum IL-4 and IL-21, suggesting a potential role in the pathogenesis of UC.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Yan Long, Jinghong Feng, Yinting Ma, Yuanyuan Sun, Lijuan Xu, Ying Song, Chen Liu
Summary: This study comprehensively analyzed circulating T-cell subsets in microscopic polyangiitis (MPA) patients, finding decreased Tfr levels and impaired function, while Tfh subsets showed enhanced function. The imbalance of Tfr and Tfh subsets in MPA patients is associated with increased levels of autoantibodies, proposing a new mechanism for the pathogenesis of MPA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Juan-Juan Zhu, Zhi-Tong Jiang, Chen Liu, Yi-Feng Xi, Jin Wang, Fang-Fang Yang, Wei-Juan Yao, Wei Pang, Li-Li Han, Yong-He Zhang, An-Qiang Sun, Jing Zhou
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Hematology
Zhenxue Li, Xiaoning Chen, Songsong Lu, Lei Zhao, Mengjie Zhu, Qinzhu Xu, Ying Song, Chen Liu
JOURNAL OF HEMATOPATHOLOGY
(2020)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)