Article
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Robyn L. McClelland, Susan R. Heckbert, Michael Criqui, Parveen Garg
Summary: Elevated coronary artery calcium (CAC) volume and density are associated with an increased risk of incident atrial fibrillation (AF), with CAC volume showing a stronger association. The association between CAC and AF appears to be independent of plaque density.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emanuel Amezcua-Castillo, Hector Gonzalez-Pacheco, Arturo Saenz-San Martin, Pablo Mendez-Ocampo, Ivan Gutierrez-Moctezuma, Felipe Masso, Daniel Sierra-Lara, Rashidi Springall, Emma Rodriguez, Alexandra Arias-Mendoza, Luis M. Amezcua-Guerra
Summary: Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide, and inflammation plays a crucial role in the pathogenesis of coronary artery disease (CAD). C-reactive protein (CRP), as an inflammatory marker, has been widely used in cardiovascular risk assessment and therapeutic decision-making. Pharmacological interventions with anti-inflammatory properties have also shown promising effects in reducing cardiovascular risks and CRP levels.
Article
Pharmacology & Pharmacy
Zimo Pan, Jiayu Cheng, Wenjia Yang, Lingxia Chen, Jingtong Wang
Summary: This study evaluated the effects of colchicine treatment on hs-CRP and IL-6 levels in patients with coronary artery disease. The results showed that colchicine significantly reduced hs-CRP and IL-6 levels in these patients. Additionally, the effects of colchicine may be influenced by the duration of intervention and baseline hs-CRP levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Cardiac & Cardiovascular Systems
Yang Liu, Shaoyan Liu, Zhizhuang Zhao, Xiang Song, Haixian Qu, Hongbin Liu
Summary: The study revealed a positive correlation between plasma PAG levels and coronary atherosclerotic burden, with higher PAG levels associated with obstructive CAD and high coronary lesion complexity.
Article
Multidisciplinary Sciences
Mu-Cyun Wang, Che-Chen Lin, Hsiu-Yin Chiang, Hung-Lin Chen, Hsiu-Chen Tsai, Wen-Yuan Lin, Hung-Chi Ho, Chin-Chi Kuo
Summary: This study investigated the association between coronary artery calcium (CAC) and all-cause mortality in an Asian cohort. The results showed that higher CAC scores were associated with increased risk of death, and age was found to be a moderating variable.
Article
Medicine, General & Internal
Lan-Anh Nguyen, Sophia Houriez-Gombaud-Saintonge, Etienne Puymirat, Umit Gencer, Thomas Dietenbeck, Kevin Bouaou, Alain De Cesare, Emilie Bollache, Elie Mousseaux, Nadjia Kachenoura, Gilles Soulat
Summary: This study compares the diagnostic value of different methods, including applanation tonometry and MRI, in evaluating aortic stiffness in high-risk coronary artery disease patients. The results suggest that 4D flow MRI provides the best diagnostic performances in identifying severe stable CAD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Margaretha Persson, Martin Adiels, Elias Bjornson, Carl Bonander, Hakan Ahlstrom, Joakim Alfredsson, Oskar Angeras, Goran Berglund, Anders Blomberg, John Brandberg, Mats Borjesson, Kerstin Cederlund, Ulf de Faire, Olov Duvernoy, Orjan Ekblom, Gunnar Engstrom, Jan E. Engvall, Erika Fagman, Mats Eriksson, David Erlinge, Bjorn Fagerberg, Agneta Flinck, Isabel Goncalves, Emil Hagstrom, Ola Hjelmgren, Lars Lind, Eva Lindberg, Per Lindqvist, Johan Ljungberg, Martin Magnusson, Maria Mannila, Hanna Markstad, Moman A. Mohammad, Fredrik H. Nystrom, Ellen Ostenfeld, Anders Persson, Annika Rosengren, Anette Sandstrom, Anders Sjalander, Magnus C. Skold, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Tomas Jernberg
Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.
Article
Cardiac & Cardiovascular Systems
Emma J. Hollenberg, Fay Lin, Michael J. Blaha, Matthew J. Budoff, Inge J. van den Hoogen, Umberto Gianni, Yao Lu, A. Maxim Bax, Alexander R. van Rosendael, Sara W. Tantawy, Daniele Andreini, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Pedro de Araujo Goncalves, Martin Hadamitzky, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Alessia Gimelli, Sang-Eun Lee, Jeroen J. Bax, Daniel S. Berman, Stephanie L. Sellers, Jonathon A. Leipsic, Ron Blankstein, Jagat Narula, Hyuk-Jae Chang, Leslee J. Shaw
Summary: It remains unclear whether a coronary artery calcium (CAC) score alone is sufficient to determine the risk of obstructive and nonobstructive atherosclerotic plaque in symptomatic patients. This study found that the characterization of atherosclerotic disease burden by CAC score is imperfect, but subgroups of CAC scores showed pathogenic patterns of disease progression and stratified long-term prognostic risk.
JACC-CARDIOVASCULAR IMAGING
(2022)
Review
Medicine, General & Internal
Shuangyan Luo, Jin Zhang, Biyan Li, Hui Wu
Summary: This meta-analysis found that elevated baseline CRP level was associated with adverse outcomes in patients with stable CAD, indicating its predictive value.
Article
Multidisciplinary Sciences
Chul-Hyun Park, Yong-Taek Lee, Kyung Jae Yoon
Summary: There is a limited understanding of the relationship between osteosarcopenia and coronary artery disease. This study aimed to investigate the association between osteosarcopenia and coronary artery calcification (CAC) scores in asymptomatic adults. The results showed that osteosarcopenia was independently associated with a higher prevalence of subclinical coronary atherosclerosis.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Ghilas Rahoual, Michel Zeitouni, Etienne Charpentier, Paul-Gydeon Ritvo, Stephanie Rouanet, Niki Procopi, Sena Boukhelifa, Pierre Charleux, Paul Guedeney, Mathieu Kerneis, Olivier Barthelemy, Johanne Silvain, Gilles Montalescot, Alban Redheuil, Jean-Philippe Collet
Summary: This study aimed to compare the coronary plaque characteristics between individuals with premature coronary artery disease (CAD) and those without overt cardiovascular disease. The results showed that individuals with premature CAD had a higher prevalence of non-calcified plaques and high-risk plaques (HRP), contributing to disease progression with multiple recurrences. A comprehensive assessment of plaque characteristics may further risk stratify patients beyond traditional risk factors.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Anesthesiology
Seoyeong Park, Karam Nam, Tae Kyong Kim
Summary: This study found that preoperative FAR is significantly associated with all-cause mortality in patients undergoing OPCAB, with higher FAR indicating increased mortality risk.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Carlo Andrea Pivato, Davis Jones, Davide Cao, Samantha Sartori, Mauro Chiarito, Johny Nicolas, Zhongjie Zhang, Frans Beerkens, Matteo Nardin, Hanbo Qiu, Victor Razuk, Daniel Feldman, Vaishali Kumaraguru, Giulio G. Stefanini, Joseph Sweeny, Usman Baber, George Dangas, Samin K. Sharma, Annapoorna Kini, Roxana Mehran
Summary: Elevated levels of high sensitivity C-reactive protein (hsCRP) after percutaneous coronary intervention (PCI) is associated with worse ischemic outcomes, including all-cause mortality, in both diabetic and nondiabetic patients. Inflammation, indicated by high hsCRP levels, may increase cardiovascular risk independent of diabetes status.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Si-Si Zhang, Wen-Yi Hu, Yi-Jing Li, Juan Yu, Shang Sang, Zakareya M. Alsalman, Da-Qi Xie
Summary: This study investigates the association between lp(a) variability and mean CRP levels in patients undergoing percutaneous coronary intervention (PCI). The results show that lp(a) variability is positively correlated with mean follow-up CRP level, suggesting that high variability can be considered an independent risk factor for increased post-PCI CRP level.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Cardiac & Cardiovascular Systems
Ryuta Watanabe, Koichi Nagashima, Yuji Wakamatsu, Naoto Otsuka, Katsuaki Yokoyama, Naoya Matsumoto, Takayuki Otsuka, Shinya Suzuki, Akio Hirata, Masato Murakami, Mitsuru Takami, Masaomi Kimura, Hidehira Fukaya, Shiro Nakahara, Takeshi Kato, Hiroshi Hayashi, Yu-Ki Iwasaki, Wataru Shimizu, Ikutaro Nakajima, Tomoo Harada, Junjiroh Koyama, Ken Okumura, Michifumi Tokuda, Teiichi Yamane, Kojiro Tanimoto, Yukihiko Momiyama, Noriko Nonoguchi, Kyoko Soejima, Koichiro Ejima, Nobuhisa Hagiwara, Masahide Harada, Kazumasa Sonoda, Masaru Inoue, Koji Kumagai, Hidemori Hayashi, Yoshinao Yazaki, Kazuhiro Satomi, Yuji Watari, Yasuo Okumura
Summary: This study revealed different determinants for post-ablation recurrence and adverse clinical events (AEs) in atrial fibrillation (AF) patients. Female sex, persistent AF, and enlarged left atrial diameter were related to post-ablation recurrence, while advanced age, comorbidities, and left ventricular and renal dysfunction were associated with AEs rather than recurrence. These findings have implications for determining ablation indications and post-ablation management.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Keisuke Usuda, Takeshi Kato, Toyonobu Tsuda, Hayato Tada, Satoru Niwa, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Hiroshi Furusho, Masaaki Kawashiri, Masayuki Takamura, Takayuki Otsuka, Shinya Suzuki, Akio Hirata, Masato Murakami, Mitsuru Takami, Masaomi Kimura, Hidehira Fukaya, Shiro Nakahara, Wataru Shimizu, Yu-ki Iwasaki, Hiroshi Hayashi, Tomoo Harada, Ikutaro Nakajima, Ken Okumura, Junjiroh Koyama, Michifumi Tokuda, Teiichi Yamane, Yukihiko Momiyama, Kojiro Tanimoto, Kyoko Soejima, Noriko Nonoguchi, Koichiro Ejima, Nobuhisa Hagiwara, Masahide Harada, Kazumasa Sonoda, Masaru Inoue, Koji Kumagai, Hidemori Hayashi, Kazuhiro Satomi, Yoshinao Yazaki, Yuji Watari, Masaru Arai, Ryuta Watanabe, Katsuaki Yokoyama, Naoya Matsumoto, Koichi Nagashima, Yasuo Okumura
Summary: The maintenance of sinus rhythm following catheter ablation for atrial fibrillation is associated with lower rates of major adverse cardiac and cerebrovascular events, as shown in a multicenter cohort study in Japan.
Article
Cardiac & Cardiovascular Systems
Stephan Achenbach, Friedrich Fuchs, Alexandra Goncalves, Claudia Kaiser-Albers, Ziad A. Ali, Frank M. Bengel, Stefanie Dimmeler, Zahi A. Fayad, Alexandre Mebazaa, Benjamin Meder, Jagat Narula, Amil Shah, Sanjay Sharma, Jens-Uwe Voigt, Sven Plein
Summary: Cardiovascular imaging plays a crucial role in precision medicine by aiding in the diagnosis, management, and individualized treatment of cardiovascular diseases.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Editorial Material
Medicine, General & Internal
Hiroshi Kudo, Chieko Miyata, Yoshiki Kawaguchi, Yutaka Yachi, Masaki Shinfuku, Takayuki Kinoshita, Tomohiro Kurihara, Yukihiko Momiyama, Tonghyo Chong, Yoshiro Kobayashi, Mihiro Takazawa, Kenji Itoh, Koichi Tsunoda
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Masayuki Aoyama, Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kojiro Tanimoto, Masato Nakamura, Kazuo Kondo, Yukihiko Momiyama
Summary: This study found that plasma fortilin levels are elevated in patients with coronary artery disease (CAD), especially in those with severe disease involving multiple stenotic vessels. Fortilin levels were also found to be associated with the severity of CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Mohammed T. Hudda, Jonathan C. K. Wells, Linda S. Adair, Jose R. A. Alvero-Cruz, Maxine N. Ashby-Thompson, Martha N. Ballesteros-Vasquez, Jesus Barrera-Exposito, Benjamin Caballero, Elvis A. Carnero, Geoff J. Cleghorn, Peter S. W. Davies, Malgorzata Desmond, Delan Devakumar, Dympna Gallagher, Elvia Guerrero-Alcocer, Ferdinand Haschke, Mary Horlick, Houda Ben Jemaa, Ashraful Khan, Amani Mankai, Makama A. Monyeki, Hilde L. Nashandi, Luis Ortiz-Hernandez, Guy Plasqui, Felipe F. Reichert, Alma E. Robles-Sardin, Elaine Rush, Roman J. Shypailo, Jakub G. Sobiecki, Gill A. ten Hoor, Jesus Valdes, V. Pujitha Wickramasinghe, William W. Wong, Richard D. Riley, Christopher G. Owen, Peter H. Whincup, Claire M. Nightingale
Summary: This study evaluated the performance of a UK based prediction model for estimating fat-free mass in children and adolescents in non-UK settings. The model showed good predictive ability in all countries, with high R2 values and good calibration. The model's performance was consistent across different genders, ages, ethnicities, and income groups.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Engineering, Biomedical
Max L. L. Senders, Claudia Calcagno, Ahmed Tawakol, Matthias Nahrendorf, Willem J. M. Mulder, Zahi A. A. Fayad
Summary: Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and HIV impact the haematopoietic system and may worsen pre-existing atherosclerosis. Whole-body PET/MRI imaging has been used to study the interplay between the haematopoietic system and atherosclerosis. In this Perspective, the applicability of integrated PET/MRI for studying immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease is reviewed.
NATURE BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ana Devesa, Philip M. Robson, Renata Pyzik, Adam Jacobi, Munir Ghesani, Anelechi Anyanwu, Donna Mancini, Zahi A. Fayad, Maria Giovanna Trivieri
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Agronomy
Alfonso A. Gardea-Bejar, Alberto Sanchez-Estrada, Jesus A. Orozco-Avitia, Martin E. Tiznado-Hernandez, Rosalba Troncoso-Rojas, Jorge N. Mercado-Ruiz, Angel J. Ojeda-Contreras, Judith Fortiz-Hernandez, Alma E. Robles-Sardin
Summary: In this experiment, isothermal microcalorimetry was used to objectively measure the quality loss of asparagus spears during postharvest storage. A regression analysis showed a determination coefficient of 0.79 and 0.87 between metabolic heat and respiration rate at 2 degrees C and 5 degrees C, respectively. Regression analysis also indicated a relationship between metabolic heat and fructose (0.5) and glucose (0.67) at 2 degrees C, as well as fructose (0.79) and glucose (0.76) at 5 degrees C. This method proved to be sensitive in detecting changes in postharvest parameters commonly used to evaluate asparagus spears quality.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Yukihiko Momiyama, Yoshimi Kishimoto, Emi Saita, Masayuki Aoyama, Reiko Ohmori, Kazuo Kondo
Summary: Several cohort studies have shown that the Japanese diet is associated with reduced cardiovascular disease mortality, but the results are inconsistent and most studies were conducted in the 1990s. To further investigate this association, this study examined 802 patients undergoing coronary angiography and found that the intake of fish, soy products, vegetables, seaweed, fruits, and green tea was lower in patients with coronary artery disease (CAD), especially those with myocardial infarction (MI), compared to those without CAD. The Japanese diet score was significantly lower in CAD patients and the proportion of CAD and MI decreased with higher Japanese diet scores.
Article
Medicine, General & Internal
Akhil Vaid, Ashwin Sawant, Mayte Suarez-Farinas, Juhee Lee, Sanjeev Kaul, Patricia Kovatch, Robert Freeman, Joy Jiang, Pushkala Jayaraman, Zahi Fayad, Edgar Argulian, Stamatios Lerakis, Alexander W. Charney, Fei Wang, Matthew Levin, Benjamin Glicksberg, Jagat Narula, Ira Hofer, Karandeep Singh, Girish N. Nadkarni
Summary: In simulated critical care settings, a universally effective model-updating approach for maintaining model performance does not seem to exist. Model use may have to be recorded to maintain viability of predictive modeling.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
Summary: Vanin-1 is a protein associated with oxidative stress and has been found to be related to the presence and severity of coronary artery disease (CAD). A study on 388 patients with CAD found that higher plasma concentrations of Vanin-1 were associated with the presence and severity of CAD.
Article
Health Care Sciences & Services
Kim-Anh-Nhi Nguyen, Pranai Tandon, Sahar Ghanavati, Satya Narayana Cheetirala, Prem Timsina, Robert Freeman, David Reich, Matthew A. Levin, Madhu Mazumdar, Zahi A. Fayad, Arash Kia
Summary: This study evaluated the use of a machine learning model to predict the need for intubation within 24 hours by combining chest radiographs and electronic medical records data. The results showed that the fusion model significantly improved the accuracy of prediction, which can help optimize clinical decision-making.
JMIR FORMATIVE RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Judit Morla-Folch, Anna Ranzenigo, Zahi Adel Fayad, Abraham Jozef Petrus Teunissen
Summary: Nanomaterials have revolutionized medicine by allowing control over drugs' pharmacokinetics, biodistribution, and biocompatibility. However, most nanotherapeutics exhibit high heterogeneity, characterized by variations in size, shape, charge, composition, and ligand functionalization. This review explores the sources and effects of nanotherapeutic heterogeneity, and discusses its impact on in vitro and in vivo behavior. The review also highlights the complications introduced by nanotherapeutic heterogeneity in experimental readouts and clinical translation, and offers strategies for minimizing heterogeneity and improving the reproducibility and efficacy of nanotherapeutics.
Article
Endocrinology & Metabolism
Rogelio Gonzalez-Arellanes, Rene Urquidez-Romero, Alejandra Rodriguez-Tadeo, Julian Esparza-Romero, Rosa Olivia Mendez-Estrada, Erik Ramirez-Lopez, Alma-Elizabeth Robles-Sardin, Bertha-Isabel Pacheco-Moreno, Heliodoro Aleman-Mateo
Summary: This study compared the fat-free mass component values of older Hispanic adults to cadaver reference values and found that certain factors can affect the density of fat-free mass and impact body composition estimations.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)