Article
Biochemistry & Molecular Biology
Fu Zhong, Shurao Liu, Yue Li, Guanyu Li, Ming Liu, Jingzhi Wang, Weijing Cui, Yanhong Suo, Xia Gao
Summary: This study found elevated serum levels of ANGPTL3 in PNS patients, which were correlated with lipid levels. Experimental results suggest that ANGPTL3 may contribute to hyperlipidemia and proteinuria in PNS. Gene knockout or overexpression had effects on lipid metabolism in mice.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Carlos A. Aguilar-Salinas, Rita A. Gomez-Diaz, Pablo Corral
Summary: This article presents an update on current and upcoming therapies for patients with primary hyperlipidemia, including newly authorized medications that have additive effects with currently available therapies. These new medications may increase the likelihood of achieving treatment targets for patients and could be a safer alternative for those with side effects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Yue Li, Qingju Liu, Chengdong Kang, Weijing Cui, Zichuan Xu, Fu Zhong, Xia Gao
Summary: This study demonstrated a correlation between serum and urine ANGPTL8 levels in primary nephrotic syndrome patients with blood lipid levels and proteinuria, suggesting a potential role of ANGPTL8 in the development of hyperlipidemia and proteinuria in primary nephrotic syndrome.
Article
Cardiac & Cardiovascular Systems
Yara Abou Khalil, Jean-Pierre Rabes, Catherine Boileau, Mathilde Varret
Summary: APOE gene variants are associated with dyslipidemias and cardiovascular risk. Further studies are needed to understand the full extent of APOE involvement in diseases like ADH.
Article
Endocrinology & Metabolism
Dan-Tong Zhao, Hui-Ping Yan, Ying Han, Wei-Ming Zhang, Yan Zhao, Hui-Yu Liao
Summary: This study investigated the main metabolic risk factors in PBC patients in China and their prognostic values for liver-related outcomes. The study found that hyperlipidemia was associated with a lower risk of liver-related death, while hypertension was associated with a higher risk of liver-related death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yin Qin, Ruyan Fan, Yingxin Liu, Shuyi Qiu, Lu Wang
Summary: This study investigated the liver protective effect of Rubus corchorifolius fruit extract (RCE) on mice with high-fat-diet-induced NAFLD and explored the potential mechanisms through transcriptomics and metabolomics analysis. The results showed that RCE contains polyphenolic compounds and has a modulatory effect on oxidative stress and inflammatory responses in the liver. Additionally, RCE intervention significantly affected metabolic pathways associated with glycolipid metabolism. Therefore, intake of RCE may be an effective strategy to alleviate liver damage.
Article
Orthopedics
Erick Marigi, Ian Marigi, Matthew M. Crowe, Cedric J. Ortiguera, Cameron K. Ledford, Jean-David Werthel, John W. Sperling, Joaquin Sanchez-Sotelo, Bradley S. Schoch
Summary: In patients undergoing shoulder arthroplasty, the presence of Metabolic Syndrome (MetS) did not significantly increase the risk of postoperative complications, infection, reoperation, or revision; however, in the subgroup of RSA, complications were more common in patients with MetS. Individual risk factors may be more appropriate to consider prior to aTSA rather than the umbrella diagnosis of MetS.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Medicine, General & Internal
Z. Liang, L. Zhao, Y. Lou, S. Liu
Summary: Genetically predicted circulating lipids and lipid-lowering drugs are not causally associated with the risk of epilepsy.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Dawoud Sulaiman, Leo Sungwong Choi, Hyeong Min Lee, Jaejin Shin, Dong Hwan Kim, Keun Woo Lee, Pierre Eftekhari, Angelique Quartier, Hyung Soon Park, Srinivasa T. Reddy
Summary: Vutiglabridin is a synthetic small molecule in clinical development for the treatment of obesity. It was found to interact with PON1 and protect it from oxidative damage. In mouse experiments, Vutiglabridin treatment increased plasma PON1 levels and activity, suggesting post-transcriptional modulation of PON1 by Vutiglabridin.
Article
Food Science & Technology
Min Zhang, Xiaoying Zou, Yixuan Du, Zhuangguang Pan, Fangqing He, Yuanming Sun, Meiying Li
Summary: This research investigated the anti-hyperlipidemia effects of alliin in vivo and its potential mechanisms using transcriptomics and metabolomics analysis. The results showed that high doses of alliin intervention significantly decreased serum total cholesterol and liver malondialdehyde levels while increasing liver superoxide dismutase and catalase levels. Transcriptomics analysis revealed several genes involved in steroid biosynthesis, triglyceride metabolism, drug metabolism-cytochrome P450, and the PI3K-Akt signaling pathway. Metabolomics analysis identified significant differences in carboxylic acids between the alliin group and the high-fat diet group. The study provides a theoretical framework for understanding the lipid-lowering mechanism of alliin and suggests potential market opportunities for its development and utilization in improving the health status of individuals with hyperlipidemia.
Article
Chemistry, Medicinal
Haixia Ge, Weitao Zhang, Kai Yuan, Hanyue Xue, Hao Cheng, Weijiao Chen, Yishi Xie, Jian Zhang, Xiaojun Xu, Peng Yang
Summary: Through the synthesis and testing of new tetrahydroprotoberberine derivatives, it was found that one compound (number 49) could significantly reduce intracellular levels of total cholesterol and triglycerides, and showed good bioavailability and efficacy in animal experiments, making it a promising candidate for new hyperlipidemia treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Ange Ahoussougbemey Mele, Riaz Mahmood, Henry Ogbuagu, Jason Fombi
Summary: PBC is a chronic autoimmune liver disease characterized by the destruction of intrahepatic bile ducts, portal inflammation, and scarring. Cholestasis leads to reduced bile acid production, resulting in endogenous cholesterol synthesis in the liver and secretion of very low-density lipoprotein.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Polymer Science
Gaurav Kant Saraogi, Siddharth Tholiya, Yachana Mishra, Vijay Mishra, Aqel Albutti, Pallavi Nayak, Murtaza M. Tambuwala
Summary: A study aimed to fabricate Pravastatin-loaded nanogel for hyperlipidemia treatment. The nanogel formulation showed sustained drug release, high drug entrapment efficacy, and lower toxicity compared to the pure drug solution. These findings support the potential use of pravastatin-loaded nanogel as an effective and safe nano delivery system for hyperlipidemia treatment.
Review
Medicine, General & Internal
Anna Bryl, Malgorzata Mrugacz, Mariusz Falkowski, Katarzyna Zorena
Summary: Diabetes mellitus is a significant social issue, and its retinal complications are major causes of blindness worldwide. Glucose level, hypertension, and hyperlipidemia have been found to be related to the development of diabetes complications. However, the exact mechanisms of this effect have not been fully explained.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Suzete Costa, Jose Guerreiro, Ines Teixeira, Dennis K. Helling, Joao Pereira, Ceu Mateus
Summary: This study conducted cost-effectiveness and cost-utility analyses of a collaborative care intervention in hypertension and hyperlipidemia management between pharmacies and primary care, and compared it with usual care. The results showed that this intervention did not achieve reasonable levels of cost-effectiveness or cost-utility.
FRONTIERS IN PHARMACOLOGY
(2022)
