Article
Cardiac & Cardiovascular Systems
Sarah Gephine, Stephanie Fry, Emilie Margoline, Alice Gicquello, Cecile Chenivesse, Jean-Marie Grosbois
Summary: This study aimed to evaluate the effects of home-based pulmonary rehabilitation (PR) on adults with severe asthma who have experienced chronic stressors. The results showed that despite facing long-term stress, these individuals could still benefit from PR and experience improvements in anxiety, depression, quality of life, and exercise capacity.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Ciara McCormack, Brona Kehoe, Sarah J. Hardcastle, Noel McCaffrey, Andrew McCarren, Sean Gaine, Brian McCullagh, Niall Moyna
Summary: The study investigates the feasibility, acceptability, utility, and safety of a novel remotely supervised home-based exercise programme for PH patients. Home-based exercise programmes have the potential to increase the availability and accessibility of exercise training as an adjunct therapy in PH, improving quality of life and physical function.
Article
Geriatrics & Gerontology
Keenan A. Ramsey, Paula Loveland, Anna G. M. Rojer, Linda Denehy, Rose Goonan MOTPrac, Celia Marston, Jacqueline E. Kay, Jacinta Brenan, Marijke C. Trappenburg, Wen Kwang Lim, Esmee M. Reijnierse, Carel G. M. Meskers, Andrea B. Maier
Summary: The study found that home-based geriatric rehabilitation patients were more physically active than hospital-based patients, regardless of sex and baseline physical function matching, supporting the implementation of home-based rehabilitation for elderly patients.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Rehabilitation
Nikhil K. Prasad, Rashmita Bajracharya, Marniker Wijesinha, Alan Rathbun, Denise Orwig, Laurence Magder, Ann Gruber-Baldini, Kathleen Mangione, Rebecca L. Craik, Jay Magaziner
Summary: This study compares participants from two different studies and finds that home-based multi-component physical therapy programs can provide better functional improvement after hip fracture compared to usual care.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zyad T. Saleh, Rami A. Elshatarat, Abdulaziz Mofdy Almarwani, Naif S. Alzahrani, Fahad M. Alhowaymel, Khadega Ahmed Elhefnawy, Nora Helmi Elneblawi, Ateya Megahed Ibrahim, Donia Elsaid Zaghamir, Tagreed O. Shawashi
Summary: Physical activity behavior change is challenging in heart failure patients, even after participation in cardiac rehabilitation programs. Baseline demographic, physical activity levels, psychological distress, and clinical variables can predict physical activity behavior change. Pre-intervention physical activity levels and depressive symptoms are key factors in designing effective home-based cardiac rehabilitation interventions.
Article
Oncology
Monia Allisen Accogli, Monica Denti, Stefania Costi, Stefania Fugazzaro
Summary: The purpose of this study was to assess the feasibility of therapeutic education and physical activity (TEPA) for patients with hematologic cancer and the impact of TEPA on clinical outcomes. The results showed that patients had a high level of adherence to TEPA and no adverse events were reported. However, this intervention did not have a significant impact on fatigue, psychological distress, quality of life, or functional exercise capacity.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Grace O. Dibben, Melvyn Hillsdon, Hasnain M. Dalal, Lars H. Tang, Patrick Joseph Doherty, Rod Taylor
Summary: This study aimed to quantify the impact of a home-based cardiac rehabilitation intervention (REACH-HF) on objectively assessed physical activity (PA) of heart failure (HF) patients, and explore the associations between patient characteristics and changes in PA. The results showed that although there was no significant difference in overall PA levels between the REACH-HF intervention group and the control group, the REACH-HF group had increased weekday MVPA, light PA, and decreased inactivity compared to the control group. Baseline PA levels were found to be highly predictive of PA change.
Review
Engineering, Biomedical
Sharon Fong Mei Toh, Kenneth N. K. Fong, Pablo Cruz Gonzalez, Yuk Ming Tang
Summary: This review examines the use of wearable technologies in self-directed rehabilitation in the home setting, specifically focusing on stroke rehabilitation. The review identifies interventions such as virtual reality, stimulation-based training, robotic therapy, and activity trackers that utilize wearable technologies. Evidence supports the effectiveness of stimulation-based training and activity trackers for upper limb rehabilitation, but is limited for virtual reality and inconsistent for robotic training. There is a lack of research on wearable technologies for lower limb rehabilitation. The importance of this topic deserves a rating of 8 out of 10.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Respiratory System
Sarah L. Finnegan, Michael Browning, Eugene Duff, Catherine J. Harmer, Andrea Reinecke, Najib M. Rahman, Kyle T. S. Pattinson
Summary: Brain activity to breathlessness related cues is a strong predictor of clinical improvement in breathlessness over pulmonary rehabilitation.
Article
Respiratory System
Marc Spielmanns, Rainer Gloeckl, Inga Jarosch, Daniela Leitl, Tessa Schneeberger, Tobias Boeselt, Stephan Huber, Pawandeep Kaur-Bollinger, Bernhard Ulm, Claudia Mueller, Jonas Bjoerklund, Sabine Spielmanns, Wolfram Windisch, Anna-Maria Pekacka-Egli, Andreas Rembert Koczulla
Summary: This study investigated the effects of a smartphone application on maintaining physical activity in patients with COPD. The results showed that using the Kaia app can help patients maintain their physical activity levels after rehabilitation and improve related symptoms.
Article
Respiratory System
Lina Butane, Liene Spilva-Ekerte, Matiss Sablinskis, Andris Skride, Daina Smite
Summary: The individually tailored 12 weeks home-based physiotherapy program has a positive impact on exercise capacity and daily physical activity level in patients with PAH.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Review
Respiratory System
Zhenzhen Feng, Jiajia Wang, Yang Xie, Jiansheng Li
Summary: Exercise-based pulmonary rehabilitation has positive effects on improving quality of life, exercise tolerance, and some aspects of pulmonary function in adults with asthma, making it a potential supplementary therapy. However, more high-quality randomized controlled trials with larger sample sizes are needed to further verify its effectiveness.
RESPIRATORY RESEARCH
(2021)
Article
Environmental Sciences
Sindy Cedeno de Jesus, Virginia Almadana Pacheco, Agustin Valido Morales, Ana Miriam Muniz Rodriguez, Rut Ayerbe Garcia, Aurelio Arnedillo-Munoz
Summary: This study demonstrates that participation in a specific home-based pulmonary rehabilitation program can improve exercise capacity, dyspnea, walked distance, and physical activity in patients with non-cystic fibrosis bronchiectasis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Yanping Duan, Xin Li, Lan Guo, Wei Liang, Borui Shang, Sonia Lippke
Summary: This study aims to develop and examine a WeChat mini program-based intervention for promoting physical activity and fruit and vegetable consumption among Chinese cardiovascular patients in home-based rehabilitation. The study will use a randomized controlled trial design, with 158 outpatients recruited from a cardiac rehabilitation center. The intervention will be based on the Health Action Process Approach and will consist of weekly learning sessions and incentive activities. Outcome variables include physical activity, fruit and vegetable consumption, healthy lifestyle, social-cognitive predictors of behavior change, and health outcomes. Data collection will occur at pre-test, post-test, and a 3-month follow-up.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Rehabilitation
Kornanong Yuenyongchaiwat, Chareeporn Akekawatchai
Summary: This study explored the benefits of a pedometer-based walking program plus a resistance exercise program in older adults with sarcopenia. The results showed that this intervention program could improve cardio-respiratory performance and physical activity among older individuals with sarcopenia, thereby reducing the risk of developing the condition.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Editorial Material
Allergy
Helen Fouquet, Jonathan Giovannelli, Patricia de Nadai, Joanne Balsamelli, Patrick Berger, Arnaud Bourdin, Pascal Chanez, Stephanie Fry, Thierry Perez, Antoine Magnan, Marina Pretolani, Camille Taille, Anne Tsicopoulos, Cecile Chenivesse
Summary: This exploratory study suggests that CCL18 may not be an effective biomarker for allergic asthma endotype, but may be associated with tissue eosinophilia.
Article
Allergy
Giorgio Walter Canonica, Tim W. Harrison, Pascal Chanez, Francesco Menzella, Renaud Louis, Borja G. Cosio, Njira L. Lugogo, Arjun Mohan, Annie Burden, Esther Garcia Gil
Summary: The study showed that benralizumab can improve symptoms of NP and asthma outcomes in patients with severe, eosinophilic asthma and NP, with better effects observed in patients with high baseline SNOT-22 scores.
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Allergy
F. Mankouri, Y. Sereme, M. Michel, R. Piarroux, L. Pahus, P. Chanez, J. Vitte, M. Gouitaa
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Ioana Agache, Dario Antolin-Amerigo, Frederic de Blay, Cristina Boccabella, Cristiano Caruso, Pascal Chanez, Mariana Couto, Ronina Covar, Serge Doan, Jean-Luc Fauquert, Gail Gauvreau, Alina Gherasim, Ludger Klimek, Catherine Lemiere, Parameswaran Nair, Inigo Ojanguren, David Peden, Luis Perez-de-Llano, Oliver Pfaar, Carmen Rondon, Maia Rukhazde, Joaquin Sastre, Johannes Schulze, Diana Silva, Susan Tarlo, Sanna Toppila-Salmi, Jolanta Walusiak-Skorupa, Stefan Zielen, Ibon Eguiluz-Gracia
Summary: Allergic asthma is a common asthma phenotype that requires IgE sensitization to aeroallergens for diagnosis. However, current protocols for bronchial allergen challenge are not suitable for moderate-to-severe asthmatics or clinical practice. Correct diagnosis of allergic asthma can aid in selecting patients for immunomodulatory therapies, such as allergen sublingual immunotherapy.
Article
Critical Care Medicine
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung
Summary: By analyzing gene signatures of MC activation, we can identify phenotypes of severe asthma and indicate that MCs can have distinct transcriptional phenotypes associated with specific clinical phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Stacey N. Reinke, Shama Naz, Romanas Chaleckis, Hector Gallart-Ayala, Johan Kolmert, Nazanin Z. Kermani, Angelica Tiotiu, David Broadhurst, Anders Lundqvist, Henric Olsson, Marika Strom, Asa M. Wheelock, Cristina Gomez, Magnus Ericsson, Ana R. Sousa, John H. Riley, Stewart Bates, James Scholfield, Matthew Loza, Frederic Baribaud, Per S. Bakke, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Annelie Behndig, Florian Singer, Jacek Musial, Dominick E. Shaw, Barbro Dahlen, Sile Hu, Jessica Lasky-Su, Peter J. Sterk, Kian Fan Chung, Ratko Djukanovic, Sven-Erik Dahlen, Ian M. Adcock, Craig E. Wheelock
Summary: This study investigates the impact of asthma severity and medication on metabolic processes using metabolomics analysis. The results reveal dysregulated metabolism in severe asthma, with differences observed between OCS-treated and non-treated patients. Altered carnitine metabolism is associated with mitochondrial dysfunction in severe asthma and is independent of OCS treatment.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Rosalia Gagliardo, Fabio Bucchieri, Angela Marina Montalbano, Giusy Daniela Albano, Delphine Gras, Alberto Fucarino, Roberto Marchese, Giulia Anzalone, Chiara Lo Nigro, Pascal Chanez, Mirella Profita
Summary: The airway epithelium plays a critical role in the pathophysiology of COPD, with dysregulation of Oct4, CD146, and CD105 expression induced by cigarette smoke exposure potentially exacerbating airway epithelial dysfunction and contributing to disease progression.
Article
Biochemistry & Molecular Biology
Charlotte Vernisse, Aurelie Petit, Veronique Pantesco, Pascal Chanez, Delphine Gras, Edouard Tuaillon, Christophe Duperray, Isabelle Vachier, Said Assou, Arnaud Bourdin
Summary: This paper presents an optimized protocol for microarray analysis of intracellular target-sorted human bronchial club cells. The protocol includes fixation and permeabilization steps and the addition of RNase inhibitors to ensure the preservation of high-quality RNA. The results show successful cell sorting and the generation of a transcriptomic signature for club cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mohamad Chebbo, Said Assou, Veronique Pantesco, Catherine Duez, Marie C. Alessi, Pascal Chanez, Delphine Gras
Summary: Platelet transcriptome analysis is important for identifying disease-specific molecular signatures, but contamination during platelet purification process can greatly alter the transcriptome results, emphasizing the need for strict precautions to avoid contamination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Uruj Hoda, Stelios Pavlidis, Aruna T. Bansal, Kentaro Takahashi, Sile Hu, Francois Ng Kee Kwong, Christos Rossios, Kai Sun, Pankaj Bhavsar, Matthew Loza, Frederic Baribaud, Pascal Chanez, Stephen J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Sven-Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung
Summary: This study examines the clinical and transcriptomic features of exacerbation-prone asthma and its persistence. The frequent exacerbators (FEs) and persistent FEs (PFEs) are associated with poor asthma control and exhibit higher expression scores of type 1 and type 2 activation pathways.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Allergy
Lavinia Davidescu, Grigoriy Ursol, Oleksii Korzh, Vikranth Deshmukh, Lesia Kuryk, Monja-Marie Nortje, Olga Godlevska, Gilles Devouassoux, Eduard Khodosh, Elliot Israel, Alain Moussy, Colin Mansfield, Olivier Hermine, Pascal Chanez
Summary: Orally administered masitinib reduces the risk of asthma exacerbations in severe asthma patients and has an acceptable safety profile. It may potentially provide a new treatment option for oral corticosteroid-dependent severe asthma.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Cell Biology
Sabrina Fiouane, Mohamad Chebbo, Sophie Beley, Julien Paganini, Christophe Picard, Xavier-Benoit D'journo, Pascal-Alexandre Thomas, Jacques Chiaroni, Pascal Chanez, Delphine Gras, Julie Di Cristofaro
Summary: Uncontrolled inflammation in chronic obstructive lung diseases, such as asthma, results in respiratory exacerbation and dysfunction. This study investigates the expression of HLA-F, a molecule involved in immune cell activation, in human bronchial epithelium cells (HBEC) and platelets (PLT). The results suggest that HLA-F is expressed in both cell types under healthy conditions and is upregulated in the context of asthma-associated inflammation. These findings highlight the potential therapeutic relevance of HLA-F in controlling lung inflammation.
Article
Medicine, General & Internal
Alain Boussuges, Paul Habert, Guillaume Chaumet, Rawah Rouibah, Lea Delorme, Amelie Menard, Matthieu Million, Axel Bartoli, Eric Guedj, Marion Gouitaa, Laurent Zieleskiewicz, Julie Finance, Benjamin Coiffard, Stephane Delliaux, Fabienne Bregeon
Summary: This study found that 10% of patients had diaphragm dysfunction after severe COVID-19 pneumonia. These patients often experienced muscle pain and had a higher frequency of prior cardiothoracic or upper abdominal surgery. Pulmonary function testing showed a significant decrease in lung volumes and DLCO, and dyspnea scores were significantly increased. Most patients showed improvement in respiratory function after prolonged respiratory physiotherapy.
FRONTIERS IN MEDICINE
(2022)