Article
Pharmacology & Pharmacy
Lei Shu, Wenhua Wang, Chon-iong Ng, Xuejuan Zhang, Ying Huang, Chuanbin Wu, Xin Pan, Zhengwei Huang
Summary: This study explores the industrialization potential of solid lipid nanoparticle (SLN)-based MDIs by utilizing SLNs as a model inhalable nanoparticle system. Three types of SLN-based MDIs with functions of stabilization, cellular uptake enhancement, and targetability were successfully fabricated. The results demonstrate the feasibility and stability of these SLN-based MDIs, providing a pilot study for the scale-up of SLN-based MDIs and contributing to the future development of inhalable nanoparticles.
Review
Pharmacology & Pharmacy
Alex Wilkinson, Ashley Woodcock
Summary: The choice of asthma treatment options has significant impact on reducing greenhouse gas emissions, with strategies that replace overuse of reliever MDIs with inhaled corticosteroids having the potential to improve asthma control and reduce carbon emissions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Hadeer S. Harb, Nabila Ibrahim Laz, Hoda Rabea, Mohamed E. A. Abdelrahim
Summary: The study found that pMDI is not preferable for handling by COPD patients, and different DPIs vary in ease of use. Therefore, inhaler therapy should be individualized based on patient handling assessment with repeated counseling. Weak correlations were found between total correct steps and demographics/clinical variables.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Yuwen Huang, Fangzhou Miao, Yunjian Dai, Cuie Chang, Xiaoyu Zhang, Haibin Dai
Summary: This study evaluated the effectiveness of a standardized training model by pharmacists in improving patients' ability to use inhalers. The results showed that the standardized training significantly improved patients' ability to use inhalers correctly and addressed the influence of older age and lower education.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Francesca Buttini, Stefania Glieca, Fabio Sonvico, David A. Lewis
Summary: The urgency to replace propellants with sustainable alternatives has led to the need for investigation and reformulation of pMDIs.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Ahmed H. M. Sobh, Hoda Rabea, Manal Ali Hamouda, Farid Shawky, Haitham Saeed, Mohamed E. A. Abdelrahim
Summary: This study compared the inhalation technique using different add-on devices for pMDI and found that using advanced training tools improved the technique and enhanced drug delivery to the lungs. Although the subjects preferred the Clip-Tone device, it did not show significant superiority in lung deposition of salbutamol compared to the Flo-Tone CR.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Respiratory System
Ashley Woodcock, Kai M. Beeh, Hironori Sagara, Simon Aumonier, Emmanuel Addo-Yobo, Javaid Khan, Jorgen Vestbo, Helen Tope
Summary: When selecting inhalers and drugs for respiratory disease, considering the carbon footprint is important. Currently, the most commonly used pMDIs contain potent greenhouse gases, while DPIs and soft mist inhalers have lower carbon footprints. Analyzing the carbon footprint data of inhalers can provide insights for treatment decisions and industry initiatives.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Waleed Wael, Mark J. Sanders, Raghda R. S. Hussein, Rania M. Sarhan, Waleed Ramadan, Mohamed E. A. Abdelrahim
Summary: The study found that providing audio feedback from the Clip-tone(R) along with smartphone visual feedback application can help patients maintain deep and slow inhalation through pMDI better than relying on verbal counselling alone. The results showed that this method is more effective in optimizing aerosol delivery from the pMDI.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Allergy
Erdem Topal, Mustafa Arga, Abdullah Hakan Ozmen, Muhammet Arif Kursun, Omer Adil Ilhan, Mustafa Alici
Summary: This study found that approximately one third of pharmacists were able to correctly demonstrate all steps for proper usage of pMDIs with a spacer device. This suggests that pharmacists should be included in training programs and receive continuous training on the use of pMDIs with a spacer device.
Review
Chemistry, Medicinal
Noe Garin, Borja Zarate-Tamames, Laura Gras-Martin, Raimon Mila, Astrid Crespo-Lessmann, Elena Curto, Marta Hernandez, Conxita Mestres, Vicente Plaza
Summary: We conducted a systematic review and meta-analysis on electronic monitoring devices of inhalers (EMDs) in adult patients with asthma or COPD to examine their characteristics and clinical impact. Our search yielded eight observational studies and ten clinical trials, covering a wide range of clinical outcomes. The meta-analysis showed that adherence to inhalers improved in the EMD group over a three-month period. An exploratory analysis also found an improvement in ACT score. However, other clinical outcomes showed mixed results. Overall, EMDs have the potential to optimize adherence to inhaled therapy and may be of interest for other clinical outcomes.
Review
Allergy
J. Montoro, D. Antolin-Amerigo, A. Izquierdo-Dominguez, J. J. Zapata, G. Gonzalez, A. Valero
Summary: A systematic review conducted from 2010 to 2021 found that the current CO2 emissions from pressurized metered-dose inhalers (pMDIs) accounted for only 0.0909% of total emissions in Spain. However, there is still a need for research and development of more sustainable devices due to environmental concerns.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Respiratory System
Jian-lan Hua, Xiao-fen Ye, Chun-ling Du, Ning Xie, Jie-qing Zhang, Man Li, Jing Zhang
Summary: The study analyzed PIFRs in COPD and asthma patients and found that inhaler training using In-Check DIAL(R) can help patients improve their inspiratory flow rates and ability to use DPIs.
BMC PULMONARY MEDICINE
(2021)
Article
Allergy
Jose J. Vempilly, Ali Rashidian, Vipul V. Jain, Belayneh A. Abejie, Nirav Bhakta
Summary: The study aimed to investigate the prevalence and magnitude of RV responsiveness in asthma patients. It was found that patients with lower baseline FEV1 values showed higher RV responsiveness, while the baseline RV value had minimal influence on RV responsiveness. More subjects showed isolated RV responsiveness compared to isolated FEV1 responsiveness.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Health Care Sciences & Services
Jacob Cohen, Iris Rosenbaum, Bernice Oberman, Irit Katz, Naama Sharabi, Dekel Shlomi
Summary: The objective of this study is to measure the proportion of patients who used inhalers in a fully effective way before and after receiving guidance from a pharmacist. Personal assessments and corrections by the pharmacist can improve inhaler technique in low socio-economic neighborhoods, but larger multicenter studies are needed to verify these findings.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Andrea S. Melani
Summary: Inhalers are commonly used devices for treating asthma and COPD, but misuse remains common and is associated with poor disease control. Proper practical education plays a key role in improving inhaler technique, but it is time-consuming and limited in successful experiences.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nathan A. Pinner, Carrie S. Oliphant, Jack P. Hopkins
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2010)
Editorial Material
Pharmacology & Pharmacy
Krystal L. Edwards, Marissa C. Salvo, Kristina E. Ward, Russell T. Attridge, Katie Kiser, Nathan A. Pinner, Patrick J. Gallegos, Lori Lynn Kesteloot, Ann Hylton, P. Brandon Bookstaver
ANNALS OF PHARMACOTHERAPY
(2014)
Review
Pharmacology & Pharmacy
Nathan A. Pinner, Leslie A. Hamilton, Anthony Hughes
CLINICAL THERAPEUTICS
(2012)
Article
Urology & Nephrology
Nathan A. Pinner, Robert B. Canada, Joyce E. Broyles, Joanna Q. Hudson
Article
Clinical Neurology
Nathan A. Pinner, April C. Hurdle, Carrie Oliphant, Anne Reaves, Bob Lobo, Allen Sills
WORLD NEUROSURGERY
(2010)
Review
Respiratory System
J. Andrew Woods, James S. Wheeler, Christopher K. Finch, Nathan A. Pinner
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2014)
Article
Medicine, General & Internal
Nathan Pinner, Wesley Oliver, Tara Veasey, Jessica Starr, Sarah Eudaley, Amber Hutchison, Kurt Wargo
SOUTHERN MEDICAL JOURNAL
(2019)
Review
Pharmacology & Pharmacy
Jessica A. Starr, Nathan A. Pinner, Katelin M. Lisenby, Alyssa Osmonson
Summary: SGLT2 inhibitors have shown significant benefits on cardiovascular and renal outcomes in HF patients, reducing hospitalizations for HF.
Article
Immunology
Nathan A. Pinner, Natalie G. Tapley, Katie E. Barber, Kayla R. Stover, Jamie L. Wagner
Summary: This study found that obese patients treated with beta-lactams have higher rates of treatment failure and longer hospitalization periods than nonobese patients. Future studies are needed to assess the impact of therapeutic drug monitoring and specific dosing recommendations for targeted infection types.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Jessica A. Starr, Nathan A. Pinner, Melanie Mannis, Mary Katherine Stuart
Summary: The efficacy data supporting routine use of warfarin or DOACs in CKD-5 or ESKD are limited, therefore the use of OACs in this population should be individualized. DOACs cannot currently be recommended over warfarin in patients with CKD-5 or ESKD and VTE.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Jacquie Downey, Sarah Blackwell, Kenda Germain, Nathan A. Pinner, Jessica A. Starr
Summary: This study investigated the need for DAPT in patients with nonminor ischemic stroke and found that there was no significant difference in the risk of bleeding and recurrent stroke between DAPT and SAPT. The study has some limitations, including the retrospective single-center design. Therefore, in patients with nonminor ischemic stroke, the risk and efficacy of DAPT are comparable to SAPT.
JOURNAL OF PHARMACY TECHNOLOGY
(2023)
Article
Education, Scientific Disciplines
Jessica Starr, Dana Carroll, Kristi Kelley, Nathan Pinner, Lynn Stevenson, Katelin Lisenby, Taylor Steuber
Summary: This study describes the development, implementation, and structure of an innovative evidence-based medicine (EBM) advanced pharmacy practice experience (APPE) rotation, and evaluates student pharmacists' perceptions of the course. The results indicate that students had high confidence in EBM skills following the rotation. The structure of this rotation may be applicable in various settings.
PHARMACY EDUCATION
(2022)
Article
Pharmacology & Pharmacy
Ashley Core, Nathan Pinner, Brittany Bethea, Jessica A. Starr
JOURNAL OF PHARMACY PRACTICE
(2020)
Article
Education, Scientific Disciplines
Marilyn N. Bulloch, Nathan A. Pinner, Stephen Eure
CURRENTS IN PHARMACY TEACHING AND LEARNING
(2013)
Review
Education, Scientific Disciplines
Katelin M. Lisenby, Catherine Scarbrough, Nathan A. Pinner, James Leeper, Qiong Xu, Dana G. Carroll
CURRENTS IN PHARMACY TEACHING AND LEARNING
(2018)
